Updated Edition!
Recently, several papers reported about PP353 as a new ‘wonder drug’ for chronic low back pain (cLBP). The reason is that Persica Pharmaceuticals Limited (Persica) announced positive results of a randomised, double-blind, placebo-controlled clinical trial assessing the safety and efficacy of PP353 as a treatment for patients with chronic low back pain (cLBP). PP353 is a specifically formulated combination of linezolid, iohexol and a thermosensitive gel that is injected into the degenerate lumbar disc, delivering prolonged exposure of a high concentration at the site of infection. A 2-dose regime (dosed 4 days apart) is said to eliminate the infection, thus addressing the underlying cause of cLBP which is claimed to be an infection.
Intradiscal administration of 3 mL of PP353 has been reported to be well-tolerated and based on the pharmacokinetics following a single injection, a two-dose regimen of PP353 (150 mg linezolid) on Day 1 and Day 5 ± 1 was selected to explore safety, tolerability, pharmacokinetics, and efficacy in Part B of the Persica 002 study.
The abovementioned efficacy trial enrolled 44 patients who had suffered from cLBP for more than 6 months (mean duration of 5.5 years) and had not been helped by existing non-surgical treatments. They were randomized to receive either PP353 or placebo injected into intervertebral discs. The results of the study demonstrated statistically significant and clinically meaningful results in patients with cLBP. Compared to placebo, the verum led to a 30% reduction of pain after 12 months. The placebo group did not achieve clinically meaningful change from baseline. The PP353 group also reported statistically significant and clinically meaningful reductions in disability with a within-group reduction of 9.4-points (63%) and a between-group reduction of 3.9-points (39%) from placebo in the Full Analysis Set of subjects at 12 months.
The manufacturer claims to provide an alternative, non-opioid, treatment for cLBP patients by replacing the 100-day high-dose oral antibiotics course to treat cLBP with an injectable antibiotic formulation that will achieve high local concentration and adequate duration of exposure in the spine to effect the sterilisation of the infected disc.
Local administration of antibiotic has the potential to elicit a faster response because an effective drug concentration in the infected tissue is immediately achieved. It also significantly reduces the amount of drug required, reducing the likelihood of systemic side effects, especially those associated with perturbation of the gut microbiome.
Intradiscal administration of therapeutics to treat cLBP is an established but mostly ineffective route. Persica believes that an effective treatment must address the underlying cause of disease – the infection. An effective antibacterial therapeutic should reduce the inflammatory stimuli in the intervertebral space and adjacent bone and allow repair over time, leading to a reduction in pain.
During the development of PP353, Persica tested several generic antibiotics in vitro and in vivo to find an antibiotic with the required properties: active against the bacteria identified in disc and herniated tissue samples, little to no resistance in clinical isolates, and the ability to be formulated to provide a depot to extend the duration of exposure.
To enable administration of the antibiotic, Persica developed a unique formulation which delivers the antibiotics to the site of infection and ensures that it remains within the infected area.
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Sounds good?
Yes, perhaps even a little too good to be true!
Here are some of my concerns:
- The manufacturer has, as far as I can see, not published the findings in a peer-reviewed journal and thus wants us to believe the findings without scrutinizing the methodology.
- Even if they eventually do publish the study in full, and even if it turns out to be rigorous, one would still want independent preplications.
- There is an undenialble and very substantial financial interest in the matter (anyone who comes out with an effective and safe pill against cLBP, will quickly make billions!), and one might therefore wonder how objective the manufacturer can be about the merits of PP353.
- The assumption that many cases of cLBP are caused by a disc infection is a well-known theory, but it remains largely unproven.
- As we dicuseed only recently, antibiotics have not been shown to be effective for cLBP.
Clearly, we have to wait and see – but my advice is to take PP353 with a healthy pinch of salt.
The hallmark of the Trump administration is the discrepancy between its appointees’ responsibilities and their qualifications/competence for their jobs. A well-known anti-vaccine activist assigned the job of reviewing the supposed link between vaccination and autism is a recent case in point. The Washington Post reported that David Geier has been nominated for a study on possible links between immunizations and autism. Retraction Watch recently dedicated an article to Geier pointing out that he has a long history of promoting the debunked claim of a link between vaccines and autism. In 2011, the Maryland State Board of Physicians even had to disciplin Geier for practicing medicine without a license!
The Trump administration has also announced that it will prioritize replicating medical research. At least 20 percent of the NIH budget will now be directed towards replication efforts. But studies of a link between vaccines and autism have failed to find a connection time and time again. “We have already done that many times over. It wastes valuable resources to revisit the same question instead of using them to address critical health challenges,” commented David Higgins, a practicing pediatrician and health services researcher at the University of Colorado Anschutz Medical Campus. “Re-examining settled questions that have already been repeated, replicated, and tested many times is not healthy skepticism; it’s cynicism and science denial.”
The news of the HHS study comes as measles cases in Texas increase, and further outbreaks have been reported in numerous other states, while Kennedy has downplayed the role of vaccination. As of 27 March, the US Centers for Disease Control and Prevention (CDC) has confirmed 483 measles cases in the US this year. This is the highest number of infections since 2019, when there were more than 1200 confirmed cases. The CDC is aware of more potential measles cases but is waiting for confirmation before including them in the case count.
David Geier and his father Mark Geier, MD, are known for several discredited studies claiming that thimerosal, a preservative containing low levels of ethylmercury used in some vaccines, increased the risk of autism. But Thimerosal has been reduced or eliminated from vaccines for decades, and all vaccines recommended for children 6 and younger are available in formulations that do not contain thimerosalopens in a new tab or window.
“The [Geier] studies were poorly done; they were full of confounding variables,” commented Paul Offit, MD, of Children’s Hospital of Philadelphia. The American Academy of Pediatrics warned that it contained “numerous conceptual and scientific flaws, omissions of fact, inaccuracies, and misstatements,” and failed to show a connection between thimerosal and autism.
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They say that, if you elect a clown, you’ll get a circus. So, to make the farce complete, why does RFKJr not recruit our friend Andrew Wakefield to the team of clowns, jesters and illusionists?
A long article on chiropractic casts doubt that chiropractic is useful. Here is an abbreviated version of it:
The chemistry and biology graduate from the University of Georgia, 28-year-old Caitlin Jensen, visited a chiropractor to sort out her lower back pain. During the session, the therapist performed an adjustment. It severed four arteries in her neck. She collapsed shortly after, unable to speak or move. The injury had caused her to suffer a series of strokes. Today, she has regained some movement in her head, legs and arms but she is still unable to speak, is partially blind and relies on a wheelchair.
- One 66-year-old grandmother said a visit to a chiropractor to treat her sore shoulder left her covered in bruises, hearing ringing in her ears and with a splitting pain in her jaw. She was later diagnosed by doctors with trigeminal neuralgia – a chronic pain disorder caused by a trapped or irritated nerve in the neck that causes sudden, electric shock-like pain in the face. She believes the condition – which, three years later, still sometimes leaves her unable to open her mouth wide enough to speak to her grandchildren – was triggered by a chiropractic adjustment of her neck.
- A 55-year-old woman was left with chronic neck and shoulder pain after visiting a chiropractor for a sore back. The pain was so bad she once spent 72 hours immobile and unable to sleep despite taking a concoction of painkillers.
- And a 66-year-old man says his back went into spasm as he was leaving his first chiropractor appointment – which left him hospitalised and bedbound for weeks. The intense treatment, he later learned, had pushed one of the discs of his spine out of place, causing him to lose feeling in his right leg for ever.
Faith healing is the attempt to bring about healing through divine intervention. It is a form of paranormal or ‘energy’ healing. The Bible and other religious texts provide numerous examples of divine healing, and believers see this as a proof that faith healing is possible. There are also numerous reports of people suffering from severe diseases, including cancer and AIDS, who were allegedly healed by divine intervention.
Faith healing often takes the form of laying on hands where the preacher channels the divine energy via his hands into the patient’s body. Faith healing has no basis in science, is biologically not plausible. Some methodologically flawed studies have suggested positive effects e.g. , however, this is not confirmed by sound clinical trials.
Faith healing is often alleged to be safe, and many of us might thus say: WHY NOT? The truth, however, is that it can turn into a dangerous, even fatal SCAM. It has been reported that two parents from Lansing, USA who shunned medical care for their critically ill newborn daughter because of their religious beliefs, despite warnings the baby could die, were convicted on murder and child-abuse charges stemming from the infant’s death.
Less than 24 hours after Abigail Piland was born in 2017, a midwife and her apprentice noticed the infant was very ill and advised the mother to seek immediate medical attention. The mother declined, saying the baby was “born complete” and “God makes no mistakes.” “When you see abnormal, it can stand out pretty stark,” Laurie Vance, the apprentice, testified. “We could tell pretty immediately there were concerns because of the coloring of her skin. Her skin had become yellow.” Abigail died less than two days later, the result of a treatable condition known as hemolytic disease of the newborn.
Abigail died on the morning of Feb. 9, 2017. The parents and a group of friends prayed over Abigail’s lifeless body, and no one at the home called 911 to report the death, according to testimony. Rachel Piland’s brother, Joel Kerr, who lives in San Jose, California, testified Monday that he called Child Protective Services and Lansing police after learning from other family members that Abigail had died. The baby had been dead for about nine hours by the time investigators arrived on the night of Feb. 9.
Joshua and Rachel Piland, who had been free on bond since the case began about eight years ago, were led from the courtroom in handcuffs after a jury in Ingham County Circuit Court convicted them of second-degree murder and first-degree child abuse following a two-week trial.
The jury was allowed to consider lesser charges of involuntary manslaughter and third-degree child abuse, as well as not-guilty verdicts. They nonetheless convicted the Pilands on the most serious charges. Both charges carry a maximum sentence of up to life in prison. Sentencing is set for June 11.
The jury deliberated about four hours over two days before returning its verdicts after listening to days of often complex testimony by police, lay witnesses and medical doctors.
“It’s about Abigail,” Deputy Chief Assistant Ingham County Prosecutor Bill Crino had said during closing arguments in the trial. “She didn’t choose to be born into this situation. She was vulnerable. She was not communicative. She didn’t have a voice. Today, she gets a voice.”
The attorneys for the Pilands had argued they cared for their daughter as best they could. They said Crino failed to prove the parents acted with the intent necessary for them to be guilty of murder or involuntary manslaughter.
RUDOLF STEINER died 100 years ago today – a good reason, I think, to remember the utter nonsense he postulated (not only) in the realm of healthcare. Here is a slightly abbreviated section from my recent book:
Rudolf Steiner was born on 25 February 1861 in Kraljević, Austrian-Hungarian empire. At the age of 9, Steiner allegedly had his first spiritual experience; he saw the spirit of his deceased aunt. Realizing Rudolf’s potentials, his father sent his son first to a ‘Realschule’ in Wiener Neustadt and then to the ‘Technische Hochschule’ (Technical University) in Vienna where he studied mathematics, physics, chemistry, botany, biology, literature, and philosophy. While Steiner was still a student, he was appointed as the natural science editor of a new edition of Goethe’s works.
In 1890, Steiner moved to Weimar, Germany, where he was employed at the Schiller-Goethe Archives. Concurrently, he started working for his doctoral degree, which he received in 1891 from the University of Rostock; the title of his dissertation, later published as a book, was ‘Wahrheit und Wissenschaft’ (Truth and Science).
In 1897, Steiner moved to Berlin, where he joined esoteric circles and studied Eastern and occult religions. In 1899, he married Anna Eunicke. Subsequently, Steiner met Marie von Sivers, an actress from the Baltic region and also a devotee of anthroposophy. They got married in 1914.
Steiner had by then joined the Theosophical Society and, in 1902, was made its General Secretary. Years of disagreement with key members of the organisation prompted him to leave the society in 1912. On 28 December of that year, Rudolf Steiner, along with a group of prominent German theosophists, founded the Anthroposophic Society.
Anthroposophy, a term borrowed from the 19th-century Swiss philosopher and physician Ignaz Troxler, is based on the notion that there is a spiritual world that is accessible only to the highest faculties of mental knowledge. Steiner rejected experimentation as a means of gaining knowledge; instead, he relied on imagination, inspiration and intuition. He claimed that his anthroposophy centered on “knowledge produced by the higher self in man.” He believed that humans once participated more fully in spiritual processes of the world through a dreamlike consciousness, but had since become restricted by their attachment to material things.
In 1913 at Dornach, near Basel, Switzerland, Steiner built the first ‘Goetheanum’, which he called a “school of spiritual science.” The building was destroyed by a fire in 1922 and subsequently replaced by the new ‘Goetheanum’ that still exists today. Steiner also worked on various other projects, including education (Waldorf schools) and biodynamic agriculture.
In the late 1910s, Steiner and his mistress, Ita Wegman, started working with medical doctors to create his anthroposophic medicine. In 1920, they founded the ‘Klinisch-Therapeutische Institut’ in Arlesheim, and on 21 March 1921, they organised the first of a series of courses for doctors in Dornach. This day is now considered to be the birth of anthroposophic medicine. In the same year, pharmacists and physicians gathered under Steiner’s guidance to create the pharmaceutical company, ‘Weleda’. At around the same time, Wegman founded the first anthroposophic medical clinic, the ‘Ita Wegman Clinic’ in Arlesheim.
Anthroposophic medicine cannot be adequately described through a single therapeutic modality. It has been aptly called a ‘pluriversum of theories and practices under the umbrella of an anthroposophic worldview’. The anthroposophic concept comprises a range of medications many (but not all) of which are plant-based, as well as art therapy, eurhythy (dance therapy), special dietary approaches, physiotherapy and other modalities. According to Steiner, humans have four ‘bodies’: The physical body, the ‘etheric’ body – which is based on formative forces, the ‘astral’ body – which reflects a person’s emotions and inner drives, and a conscious body – which is the domain of the ego and self.
For non-anthroposophist, these concepts are hardly comprehensible. They are based on associations between planets, metals and organs, from which therapeutic rules are derived. These affinities also form the basis of the many anthroposophical medicines, which are produced by liquefaction, aeration, solidification, combustion, potentiation and other processes. The history of the constituents of anthroposophic remedies is often considered to be more important than their material composition. According to Steiner and his substantial writings, “the spirit of the plant, which is drawn out of the tree by the parasitic plant act on the astral”. During the years before his death, Steiner, who had no medical background, often saw patients himself. He would then stare at them and divine both the diagnosis and the treatment; in other words, he acted as a clairvoyant lay-healer.
The Nazi movement had an ambivalent attitude to Steiner and to anthroposophic medicine. On the one hand, several leading Nazis such as Hess were clearly in favour of anthroposophic medicine. Steiner’s wife, Marie Steiner-von Sivers (1867 – 1948) who made significant contributions to anthroposophic medicine had publicly expressed sympathy for the Nazi regime since its beginnings. On the other hand, a political theorist of the Nazi movement, Dietrich Eckart, criticised Steiner in 1919 and (wrongly) suggested that he was a Jew. In 1921, Adolf Hitler accused Steiner of being a tool of the Jews, while other Nazis even called for a “war against Steiner”. In 1922, Steiner gave a lecture in Munich which was disrupted by Nazi thugs. Such hostilities led Steiner to leave his home in Berlin and move to Dornbach; he stated that, if the Nazis came to power in Germany, it would no longer be possible for him to live in Germany.
From 1923 on, Steiner showed signs of increasing frailness. He nonetheless continued to lecture widely. His last lecture was given in late September 1924. Steiner died at Dornach on 30 March 1925 in the presence of Ita Wegman.
The aim of this recent review was to investigate the efficacy of non-surgical and non-interventional treatments for adults with low back pain compared with placebo. It included all randomised controlled trials evaluating non-surgical and non-interventional treatments compared with placebo or sham in adults (≥18 years) suffering from non-specific low back pain.
Random effects meta-analysis was used to estimate pooled effects and corresponding 95% confidence intervals on outcome pain intensity (0 to 100 scale) at first assessment post-treatment for each treatment type and by duration of low back pain—(sub)acute (<12 weeks) and chronic (≥12 weeks). Certainty of the evidence was assessed using the Grading of Recommendations Assessment (GRADE) approach.
A total of 301 trials (377 comparisons) provided data on 56 different treatments or treatment combinations. One treatment for acute low back pain: (non-steroidal anti-inflammatory drugs (NSAIDs)), and five treatments for chronic low back pain:
- exercise,
- spinal manipulative therapy,
- taping,
- antidepressants,
- transient receptor potential vanilloid 1 (TRPV1) agonists)
were found to be efficacious. However, effect sizes were small and of moderate certainty. Three treatments for acute low back pain (exercise, glucocorticoid injections, paracetamol), and two treatments for chronic low back pain (antibiotics, anaesthetics) were not efficacious and are unlikely to be suitable treatment options; moderate certainty evidence. Evidence is inconclusive for remaining treatments due to small samples, imprecision, or low and very low certainty evidence.
The authors concluded that the current evidence shows that one in 10 non-surgical and non-interventional treatments for low back pain are efficacious, providing only small analgesic effects beyond placebo. The efficacy for the majority of treatments is uncertain due to the limited number of randomised participants and poor study quality. Further high-quality, placebo-controlled trials are warranted to address the remaining uncertainty in treatment efficacy along with greater consideration for placebo-control design of non-surgical and non-interventional treatments.
This is an important analysis, not least because of the fact that the research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The methodology is sound and the results thus seem reliable.
The findings are in keeping with what we have been discussing at nauseam here: no treatment works really well for back pain. For acute symptoms no so-called alternative medicine (SCAM) at all is efficacious. For chronic pain, spinal manipulation therapy (SMT) have small effects. As SMT is neither cheap nor free of risks, excercise is much preferable.
Considering that most SCAMs are heavily promoted for low back pain (e.g. acupuncture, Alexander technique, cupping, Gua Sha, herbal medicine, homeopathy, massage, mind-body therapies, reflexology, Reiki, yoga), this verdict is sobering indeed!
The US Health Secretary Robert F Kennedy (JFKJr) famously claimed that vitamin A could work “as a prophylaxis” of measles infection. That claim is not just wrong, it also is dangerous. Overuse of vitamin A can have serious health consequences. As a result of JFKJr yet again promoting dangerous nonsense, doctors treating patients during the measles outbreak in Texas and New Mexico are now facing the problem of vitamin A toxicity.
At Covenant Children’s Hospital in Lubbock, near the outbreak’s epicenter, several patients have been found to have abnormal liver function on routine lab tests, a probable sign that they’ve taken too much of the vitamin, according to Dr. Lara Johnson, pediatric hospitalist and chief medical officer for Covenant Health-Lubbock Service Area.
Vitamin A is fat-soluble. It therefore accumulate in organs like the liver when over-doesed. Excess vitamin A can cause dry skin and eyes, blurry vision, bone thinning, skin irritation, liver damage and other serious issues. In pregnant women, it can even lead to birth defects. Recovery for patients with acute toxicity is normally rapid, if the vitamin is discontinued. But the more serious problems with vitamin A toxicity are not always reversible.
The Council for Responsible Nutrition, a trade association for dietary supplement and functional food manufacturers, issued a statement warning parents against using high doses of vitamin A to try to keep their children from getting measles. “While vitamin A plays an important role in supporting overall immune function, research hasn’t established its effectiveness in preventing measles infection. CRN is concerned about reports of high-dose vitamin A being used inappropriately, especially in children,” the statement says.
JFKJr made his remarks in an interview with Fox News medical correspondent Dr. Marc Siegel. Snippets of the interview were featured in four Fox News or Fox Business segments airing on March 4. “They have treated most of the patients, actually, over 108 patients in the last 48 hours. And they’re getting very, very good results, they report from budesonide, which is a steroid, it’s a 30-year-old steroid,” Kennedy said in the longest of the segments. “And clarithromycin [an antibiotic] and also cod liver oil, which has high concentrations of vitamin A and vitamin D. We need to look at those therapies and other therapies,” he said in another segment. “We need to really do a good job of talking to the front-line doctors and see what is working on the ground, because those therapeutics have really been ignored by the agency for a long, long time.”
Local doctors are increasingly concerned about the growing popularity of unproven remedies for preventing and treating measles. They fear that they are causing people to delay critical medical treatment and to reject vaccination, the only proven way to prevent a measles infection.
The measles outbreak has now affected at least 379 people across Texas, New Mexico and Oklahoma. Kansas has reported 23 measles cases, and officials said that they may also be linked to the outbreak. The best measure to get to grips with the outbreak, I think, would be to make JFKJr shut up and let those who understans the issues get on with it.
I have only recently become aware of the fact that ‘Google Scholar’ offers a thing called ‘my profile‘. In my case, it contains a host of information about my published research – but, I have to admit, I only understand some of it (yes, I am not all that savvy on the Internet).
It tells me, for instance, that I have been cited just over 1000 times – not in total but in 2025! In total, the amount is more than 89000. Most satisfying and easy to understand.
My ‘H-Index’ is currently 149. This means that 149 of my papers have been cites at least 149 times – also not too difficult to comprehend. The Index is an attempt to account for both the quality and the quantity of a researchers published work. What I don’t comprehend is why, from time to time, the Index and citation numbers diminish and then climb up again. [A researcher’s h-index is defined as the highest number of h such that the researcher has h papers, each of which has been cited at least h times. But if this were true, the Index could never go down.] It might be caused by the time frame on which all this is based and that shifts as time goes on – does anyone know?
What I find interesting about my ‘profile’ is the fact that the three most-cited papers of mine are all outside the realm of so-called alternative medicine (SCAM). All are quite old; one was published as far back as 1993.
Another interesting aspect is that the frequency of my citations per year increased almost linearly from 1997 (the first year that my ‘profile’ displays) when it was just 228 to 2021 when it had reached the dizzy heights of 4826. This is remarkable because I retired in 2012/13 when I all but stopped publishing citable papers.
The most fascinating things about my ‘profile’ is, in my view, that it also offers informations about (some of) the people who were my co-authors [it would be interesting to know why some are mentioned and others aren’t]. Several of those were once members of my team, and it is brilliant to see how well some of them did. Here are the H-Indeces of those you appear on my ‘profile’ page:
- Angelo A. Izzo 98
- Myeong Soo Lee 97
- Francesca Borrelli 71
- Jo Thompson Coon 57
- Jelena Savovic 54
- IGHO ONAKPOYA 49
- HYANGSOOK LEE 47
- Paul Posadzki 44
- Alyson Huntley 34
This, I think, is a good occasion to thank not just those who are mentioned above, but also all of those members of my team who (mysteriously) are missing on this list.
Qi-gong is a branch of Traditional Chinese Medicine that employs meditation, exercise, deep breathing and other techniques with a view of strengthening the assumed life force ‘qi’ and thus improving health and prolong life. Qi-gong has ancient roots in China and has recently also become popular in other countries. There are several distinct forms of qi-gong which can be categorized into two main groups, internal qi-gong and external qi-gong. Internal qi-gong refers to a physical and mental training method for the cultivation of oneself to achieve optimal health in both mind and body. Internal qi-gong is not dissimilar to tai chi but it also employs the coordination of different breathing patterns and meditation. External qi-gong refers to a treatment where qi-gong practitioners direct their qi-energy to the patient with the intention to clear qi-blockages or balance the flow of qi within that patient. According to Taoist and Buddhist beliefs, qi-gong allows access to higher realms of awareness.
The assumptions of qi-gong are not scientifically plausible. But this does not stop enthusiasts to submit it to clinical trials.
A quasi-experimental pretest-posttest study was conducted with 231 adolescent girls aged 13-17 years suffering from premenstrual syndrome (PMS). Participants underwent a 4-week Qi Gong therapy program, with five 45-minute sessions weekly. Data were collected using a demographic questionnaire and Modified PMS Scale, analysing pre- and post-intervention symptoms through descriptive statistics, paired t-tests and chi-square tests.
The intervention significantly reduced PMS severity, with mild PMS cases increasing from 48 (20.78%) to 166 (71.86%) post-intervention. Paired t-tests revealed a highly significant mean difference in PMS scores (T = 12.251, p < 0.001).
The authors concluded that Qi Gong therapy offers a holistic, non-invasive approach for managing PMS by addressing both physiological and emotional dimensions to the condition. Its ability to balance hormones, alleviate stress and improve overall quality of life makes it a valuable addition to PMS care.
This study originated from the Department of Obstetrics and Gynecological Nursing, Nootan college of Nursing, Sankalchand Patel university, Visnagar, Gujarat, India; the Department of Pediatric Nursing of the same institution and the Department of Psychiatric Nursing of the same institution. One would have hoped that its authors know better than to draw such conclusions from such a study. Here are some points of concern:
- There is no reason why the treatment should be holistic.
- The study did not have a control group; causal inferences are thus not waarranted.
- The study did not produce any evidence to show that the treatment addressed either physiological or emotional dimensions.
- The study did not produce any evidence to show that the treatment did anything to hormones.
- The study did not produce any evidence to show that the treatment alleviated stress.
- The study did not produce any evidence to show that the treatment improved quality of life.
- I see no resason why the treatment should be promoted as a valuable addition to PMS care.
- The PMS severity changed after the treatment and not necessarily because of it.
- The true reasons it changed might be multifold, e.g.: placebo, regression towards the mean, social desirability.
- Misleading the public by drawing far-reaching conclusions has the potential to do untold harm.
I have said it often, and it saddens me to have to say it again:
If the quality of research into so-called alternative medicine (SCAM) does not improve dramatically, nobody can blame the public to not take SCAM seriously any more.
Robert F. Kennedy Jr. (RFK Jr.), America’s anti-vaxer in-chief, famously claimed his brain has been eaten by a worm. While this assumption is as ridiculous as the man himself, the actions and delusions of RFK Jr. seem almost to confirm that something fundamental must be wrong with his intellectual abilities.
Recently he said that he will be working to get cell phones out of schools. “Cell phones produce electric magnetic radiation, which has been shown to do neurological damage to kids when it’s around them all day … It’s also been shown to cause cellular damage and even cancer … Cell phone use and social media use on the cell phone has been directly connected with depression, poor performance in schools, suicidal ideation, and substance abuse … The states that are doing this have found that it is a much healthier environment when kids are not using cell phones in schools.”
There are two separate issues here:
- Limiting children’s use of cell phones might be – for several (not health-related) reasons – a reasonable idea.
- The assumption that cell phones cause the type of damage that RFK Jr. claimed is nonsense.
There is plenty of evidence on the subject, some more reliable than others. The most reliable data do not support what RFK Jr. claims. Here are a few systematic reviews on the subject:
A recent systematic review included 63 aetiological articles, published between 1994 and 2022, with participants from 22 countries, reporting on 119 different E-O pairs. RF-EMF exposure from mobile phones (ever or regular use vs no or non-regular use) was not associated with an increased risk of glioma [meta-estimate of the relative risk (mRR) = 1.01, 95 % CI = 0.89-1.13), meningioma (mRR = 0.92, 95 % CI = 0.82-1.02), acoustic neuroma (mRR = 1.03, 95 % CI = 0.85-1.24), pituitary tumours (mRR = 0.81, 95 % CI = 0.61-1.06), salivary gland tumours (mRR = 0.91, 95 % CI = 0.78-1.06), or paediatric (children, adolescents and young adults) brain tumours (mRR = 1.06, 95 % CI = 0.74-1.51), with variable degree of across-study heterogeneity (I2 = 0 %-62 %). There was no observable increase in mRRs for the most investigated neoplasms (glioma, meningioma, and acoustic neuroma) with increasing time since start (TSS) use of mobile phones, cumulative call time (CCT), or cumulative number of calls (CNC). Cordless phone use was not significantly associated with risks of glioma [mRR = 1.04, 95 % CI = 0.74-1.46; I2 = 74 %) meningioma, (mRR = 0.91, 95 % CI = 0.70-1.18; I2 = 59 %), or acoustic neuroma (mRR = 1.16; 95 % CI = 0.83-1.61; I2 = 63 %). Exposure from fixed-site transmitters (broadcasting antennas or base stations) was not associated with childhood leukaemia or paediatric brain tumour risks, independently of the level of the modelled RF exposure. Glioma risk was not significantly increased following occupational RF exposure (ever vs never), and no differences were detected between increasing categories of modelled cumulative exposure levels.
Another recent systematic review included 5 studies that reported analyses of data from 4 cohorts with 4639 participants consisting of 2808 adults and 1831 children across three countries (Australia, Singapore and Switzerland) conducted between 2006 and 2017. The main source of RF-EMF exposure was mobile (cell) phone use measured as calls per week or minutes per day. For mobile phone use in children, two studies (615 participants) that compared an increase in mobile phone use to a decrease or no change were included in meta-analyses. Learning and memory. There was little effect on accuracy (mean difference, MD -0.03; 95% CI -0.07 to 0.02) or response time (MD -0.01; 95% CI -0.04 to 0.02) on the one-back memory task; and accuracy (MD -0.02; 95%CI -0.04 to 0.00) or response time (MD -0.01; 95%CI -0.04 to 0.03) on the one card learning task (low certainty evidence for all outcomes). Executive function. There was little to no effect on the Stroop test for the time ratio ((B-A)/A) response (MD 0.02; 95% CI -0.01 to 0.04, very low certainty) or the time ratio ((D-C)/C) response (MD 0.00; 95% CI -0.06 to 0.05, very low certainty), with both tests measuring susceptibility to interference effects. Complex attention. There was little to no effect on detection task accuracy (MD 0.02; 95% CI -0.04 to 0.08), or response time (MD 0.02;95% CI 0.01 to 0.03), and little to no effect on identification task accuracy (MD 0.00; 95% CI -0.04 to 0.05) or response time (MD 0.00;95% CI -0.01 to 0.02) (low certainty evidence for all outcomes). No other cognitive domains were investigated in children. A single study among elderly people provided very low certainty evidence that more frequent mobile phone use may have little to no effect on the odds of a decline in global cognitive function (odds ratio, OR 0.81; 95% CI 0.42 to 1.58, 649 participants) or a decline in executive function (OR 1.07; 95% CI 0.37 to 3.05, 146 participants), and may lead to a small, probably unimportant, reduction in the odds of a decline in complex attention (OR 0.67;95%CI 0.27 to 1.68, 159 participants) and a decline in learning and memory (OR 0.75; 95% CI 0.29 to 1.99, 159 participants). An exposure-response relationship was not identified for any of the cognitive outcomes.
A 2022 systematic review concluded that the body of evidence allows no final conclusion on the question whether exposure to RF EMF from mobile communication devices poses a particular risk to children and adolescents.
That RFK Jr. spouts BS almost every time he opens his mouth should be an embarrassment to all US citizens. For the rest of the world, it is more than that. In fact, it is fast becoming a serious concern: sooner or later, his insane delusions will affect public health on a global scale!
