MD, PhD, MAE, FMedSci, FRSB, FRCP, FRCPEd.

quackery

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‘Bio’ – from biology

‘kin’ – from kinetics

‘ergy’ – not from energy as in physics but vital force as in chi and TCM

Together, these three terms give BIOKINERGY

Biokinergy is hardly well-known in most countries. Yet, in France, it’s all the rage. It is a manual therapy that allegedly restores the mobility of the patient’s body and increases the elasticity of its tissues while supporting the circulatory and nervous systems as well as our biological and psycho-emotional balance. It is said to incorporate concepts from osteopathy, fascia techniques, and Traditional Chinese Medicine.

Am I the only one who finds this more than a bit vague and full of platitudes?

So, what is biokinergy really?

Apparently, it is based on 4 main principles:

  1. Biomechanics
    Biokinergy takes into account the release of blockages and the rebalancing of the mobility of the different structures and tissue layers (bones, viscera, muscles, subcutaneous tissues, skin), through innovative neuro-informational processes

2. Fasciatherapy
Richly innervated, the fascias envelop, partition, and connect all our structures without discontinuity from head to toe and, as Dr. Guimberteau’s work has shown, from the skin to the depths of the bone. Their tensions are at the origin of pain, visceral dysfunctions, and disturbances of vascular and nervous exchanges which alter the functional balance of the organism. The fascia techniques developed at CERB aim, through specific treatment of the different strata of fascia, to cure all these disturbances

3. Energetics
The energetic action aims to regulate the metabolic and biochemical activity and the exchange of information that is constantly taking place between the different tissues of the body by circulatory, nervous, and electromagnetic means and by means of the meridians of Traditional Chinese Medicine.

4.Psychosomatic
As a place of affects, representations, emotions, and a tool for relationships, the body expresses our emotional damage through its tissue tensions and dysfunctions. By using the body as a mediation, Biokinergie develops a psycho-corporal approach with a therapeutic, prophylactic, and preventive aim. By going back to the origin of the stress, inscribed in the tissues, it allows patients to free themselves from their conscious and unconscious blockages in order to find a physical, emotional, and mental balance.

Biokinergy was developed by Michel LIDOREAU, a physiotherapist and osteopath, who studied shiatsu and Chinese massage. At the beginning of the 1980s, he claims to have discovered specific tissue tensions in our body, associated with both joint blockages and energetic imbalances. This led to the invention of biokinergy.

Personally, I am still puzzled and unclear about what all this is supposed to mean. Perhaps we get a bit further if we ask what the therapy is used for.

The aim of biokinergy, I learn from this seemingly competent source, is not to treat only the symptoms but to takle their causes. The body is a whole, and its imbalances can be expressed symptomatologically very far from their origin. It is important to understand that pathology is not a coincidence, but results from the accumulation of a multitude of imbalances that must be treated together if we want to be effective quickly and in the long term.

The body has an amazing memory capacity. It keeps track of all our traumas (falls, repetitive gestures, false movements, emotional shocks, fatigue, stress) in the form of tensions, blockages, and energetic [biological, metabolic] imbalances. Initially, the body compensates and adapts, but gradually these disorders add up. They then end up hampering the functioning of the joints, disturbing the activity of the organs and compressing the blood vessels and nerves. The conduction of blood and nerve impulses is no longer done correctly, which favors the installation of biological disorders, the inflammation of tissues, and the appearance of pain (tendonitis, arthritis, gastritis, colitis, etc.). This can gradually lead to tissue degeneration.

The aim of a Biokinergy treatment is therefore to restore the body’s optimal functioning by restoring the function of all systems (locomotor, visceral, vascular, nervous, hormonal, etc.); this is done by releasing areas of tension and blockages, to restore flexibility to the tissues and free up, among others, the vascular and nervous axes.

Blast! I am getting more and more lost here. This just does not make much sense. Perhaps it is best to ask what actually happens during a therapy session. Again, the seemingly competent source offers some information:

A Biokinergy session lasts about 1 hour. After a precise interrogation, it consists in “reading” the body to find the tissue windings in order to reharmonize them. Bearing in mind that the human organism forms a whole, the biokinergist applies, from coil to coil, the corrections adapted to the disorders encountered. The techniques are gentle.

Well, this isn’t all that clear either.

Let’s take another approach: is there any evidence that biokinergy works? My Medline search gives a very clear answer: “Your search for biokinergy retrieved no results.”

So, now we know!

Biokinergy serves only one proven purpose: it improves the bank balance of the therapist.

I have been informed by the publisher, that my book has been published yesterday. This is about two months earlier than it was announced on Amazon. It is in German – yes, I have started writing in German again. But not to worry, I translated the preface for you:

Anyone who falls ill in Germany and therefore needs professional assistance has the choice, either to consult a doctor or a non-medical practitioner (Heilpraktiker).

– The doctor has studied and is licensed to practice medicine; the Heilpraktiker is state-recognized and has passed an official medical examination.
– The doctor is usually in a hurry, while the Heilpraktiker takes his time and empathizes with his patient.
– The doctor usually prescribes a drug burdened with side effects, while the Heilpraktiker prefers the gentle methods of alternative medicine.

So who should the sick person turn to? Heilpraktiker or doctor? Many people are confused by the existence of these parallel medical worlds. Quite a few finally decide in favor of the supposedly natural, empathetic, time-tested medicine of the Heilpraktiker. The state recognition gives them the necessary confidence to be in good hands there. The far-reaching freedoms the Heilpraktiker has by law, as well as the coverage of costs by many health insurances, are conducive to further strengthening this trust. “We Heilpraktiker are recognized and respected in politics and society,” writes Elvira Bierbach self-confidently, the publisher of a standard textbook for Heilpraktiker.

The first consultation of our model patient with the Heilpraktiker of his choice is promising. The Heilpraktiker responds to the patient with understanding, usually takes a whole hour for the initial consultation, gives explanations that seem plausible, is determined to get to the root of the problem, promises to stimulate the patient’s self-healing powers naturally, and invokes a colossal body of experience. It almost seems as if our patient’s decision to consult a Heilpraktiker was correct.

However, I have quite significant reservations about this. Heilpraktiker are perhaps recognized in politics and society, but from a medical, scientific, or ethical perspective, they are highly problematic. In this book, I will show in detail and with facts why.

The claim of government recognition undoubtedly gives the appearance that Heilpraktiker are adequately trained and medically competent. In reality, there is no regulated training, and the competence is not high. The official medical examination, which all Heilpraktiker must pass is nothing more than a test to ensure that there is no danger to the general public. The ideas of many Heilpraktiker regarding the function of the human body are often in stark contradiction with the known facts. The majority of Heilpraktiker-typical diagnostics is pure nonsense. The conditions that they diagnose are often based on little more than naive wishful thinking. The treatments that Heilpraktiker use are either disproven or not proven to be effective.

There is no question in my mind that Heilpraktiker are a danger to anyone who is seriously ill. And even if Heilpraktiker do not cause obvious harm, they almost never offer what is optimally possible. In my opinion, patients have the right to receive the most effective treatment for their condition. Consumers should not be misled about health-related issues. Only those who are well-informed will make the right decisions about their health.

My book provides this information in plain language and without mincing words. It is intended to save you from a dangerous misconception of the Heilpraktiker profession. Medical parallel worlds with the radically divergent quality standard – doctor/Heilpraktiker – are not in the interest of the patient and are simply unacceptable for an enlightened society.

When I was still at Exeter, I used to do an average of about 4 peer reviews per week of articles that had been submitted to all sorts of journals for publication. Now I reject most of these invitations and do perhaps just one per month.

Why?

Conducting a peer review is by no means an easy task. You have to realize that the authors have usually put a lot of hard work into their paper and a lot may depend on it in terms of their future. They thus have the right to receive a fair and responsible review. To do the job properly, it took me (even with plenty of experience in reading scientific papers) between 1 and 3 hours per article. Crucially, low-quality articles typically submitted to low-quality journals are more work than papers that adhere to a certain standard.

I do not think that the journal editors who send the submissions out for review appreciate how much work they ask from the reviewers. They normally pay nothing (even if they charge exorbitant handling fees from the authors) and offer you no benefit at all. In addition, many have systems that are more than tedious asking you to register, create a pin number, etc., etc. Then you have to follow certain rules and formats that differ from journal to journal. In a word, they add an administrative burden to the task of reading, understanding, checking a paper, and composing your judgment on it.

All this can be cumbersome but it’s not the reason why I do less and less peer reviews. The true reason is that research papers on so-called alternative medicine (SCAM) are now mostly published in one of the many 3rd class SCAM journals that have recently sprung up. There are so many of them that they, of course, struggle to get enough articles to fill their pages. In turn, this means that they are far too keen to publish anything regardless of its quality or validity. As a consequence, the quality of these articles and their authors are often dismal.

Here is an example of a (rather shocking but not unusual) email I received only today; it might show you what I mean:

Dear Professor!

I want to publish some papers in “Areas related to your research field”. Can you help me? I can provide a thank you fee!

For example, I will give you a $2000 thank you fee for helping me write articles. For example, if you add my name to your article, I will give you a $1000 thank you fee. Or I can help you pay for APC.

I know this email is presumptuous, but my friends and I need to publish dozens of papers every year. If you can help me, we can cooperate for a long time. I’m not kidding, I’m very sincere!

If you are offended, please forgive me!

Look forward to your reply!

Warmly Wishes, …

When I do a review for a low-quality SCAM journal and find major defects in an article, my experience has been that the editor then decides to publish it nonetheless. When this happens, I feel frustrated and ask myself: WHY DID THEY ASK FOR MY OPINION IF THEY DO NOT ABIDE BY IT?

Thus I decided that these journals are just as well off without my contributions. So, if you are an editor of a SCAM journal, do me a favor and do not molest me with your invitations to conduct a peer review and

COUNT ME OUT!

I had come across them so often that I had almost stopped noticing them: the ‘little extras‘ that make ineffective so-called alternative medicines (SCAMs) seem effective. Then, recently, during an interview about detox diets, the interviewer responded to my explanation of the ineffectiveness of these treatments by saying: “but these diets include stopping the consumption of alcohol, cigarettes, and other harmful stuff; therefore they must be good.” This seemingly convincing argument reminded me of a phenomenon – I call it here the ‘little extra‘ – that applies to so many (if not most) SCAMs.

Let me schematically summarise it as follows:

  1. A practitioner applies an ineffective SCAM to a patient.
  2. Because it is ineffective, it has little effect other than a small placebo response.
  3. The ineffective SCAM comes with a ‘little extra‘ which is unrelated to the SCAM.
  4. The ‘little extra‘ is effective.
  5. The end result is that the ineffective SCAM appears to be effective.

The above example makes it quite clear: the detox diet is utter nonsense but, as it goes hand in hand with effective lifestyle changes, it appears to be effective. A classic case. But SCAM offers no end of similar examples:

  • Acupuncture is useless but it involves touch, time, attention, and empathy all of which are effective in making a patient feel better.
  • Chiropractic is useless but it involves touch, time, attention, and empathy all of which are effective in making a patient feel better.
  • Homeopathy is useless but it involves a long, empathic consultation and attention which are effective in making a patient feel better.
  • Osteopathy is useless but it involves touch, time, attention, and empathy all of which are effective in making a patient feel better.
  • Reflexology is useless but it involves touch, time, attention, and empathy all of which are effective in making a patient feel better.

Do I need to continue?

Probably not!

The ‘little extras‘ are often forgotten or subsumed under the heading ‘placebo’. Yet, they are not part of the placebo effect. Strictly speaking, they are concomitant treatments comparable to a pain patient using SCAM and also taking a few paracetamols. In the end, she forgets about the painkillers and thinks that her SCAM worked wonders.

Even ardent SCAM proponents have long realized this phenomenon. Here, for example, is a paper entitled ‘Acupuncture as a complex intervention: a holistic model’ by ex-colleagues of mine at Exeter looking at it but coming up with a very different perspective:

Objectives: Our understanding of acupuncture and Chinese medicine is limited by a lack of inquiry into the dynamics of the process. We used a longitudinal research design to investigate how the experience, and the effects, of a course of acupuncture evolved over time.

Design and outcome measures: This was a longitudinal qualitative study, using a constant comparative method, informed by grounded theory. Each person was interviewed three times over 6 months. Semistructured interviews explored people’s experiences of illness and treatment. Across-case and within-case analysis resulted in themes and individual vignettes.

Subjects and settings: Eight (8) professional acupuncturists in seven different settings informed their patients about the study. We interviewed a consecutive sample of 23 people with chronic illness, who were having acupuncture for the first time.

Results: People described their experience of acupuncture in terms of the acupuncturist’s diagnostic and needling skills; the therapeutic relationship; and a new understanding of the body and self as a whole being. All three of these components were imbued with holistic ideology. Treatment effects were perceived as changes in symptoms, changes in energy, and changes in personal and social identity. The vignettes showed the complexity and the individuality of the experience of acupuncture treatment. The process and outcome components were distinct but not divisible, because they were linked by complex connections. The paper depicts these results as a diagrammatic model that illustrates the components and their interconnections and the cyclical reinforcement, both positive and negative, that can occur over time.

Conclusions: The holistic model of acupuncture treatment, in which “the whole being greater than the sum of the parts,” has implications for service provision and for research trial design. Research trials that evaluate the needling technique, isolated from other aspects of process, will interfere with treatment outcomes. The model requires testing in different service and research settings.

I think the perspective of viewing SCAMs as complex interventions is needlessly confusing and deeply unhelpful. The truth is that there is no treatment that is not complex. Take a surgical treatment, for instance, it involves dozens of ‘little extras‘ that are known to be effective. Should we, therefore, try to use this fact for justifying useless surgical interventions? Or take a simple prescription of medication from a doctor. It involves time, empathy, attention, explanations, etc. all of which will affect the patient’s symptoms. Should we thus use this to justify a useless drug? Certainly not!

And for the same reason, it is nonsense to use the ‘little extras‘ that come with all the numerous ineffective SCAMs as a smokescreen that makes them look effective.

Homeopathy is touted as a panacea, we all know that. It is thus hardly surprising that it is also claimed to be an effective detox option. Here is a German article on the subject that I translated for you:

It was published on the independent health portal Lifeline. It claims that it “offers comprehensive, high-quality and understandably written information on health topics, diseases, nutrition, and fitness. Our editorial team is supported by doctors and freelance medical authors in the continuous creation and quality assurance of our content. Much of our information is multimedia-based with videos and informative image galleries. Numerous self-tests encourage interaction. In our expert advice and forums on various topics, Lifeline users can discuss topics with experts or exchange information with other users. Our information is in no way intended to be a substitute for a visit to the doctor. Rather, our aim is to qualitatively improve and support the relationship between doctor and patient through the information provided. Therefore, our contents do not serve the purpose of arbitrary diagnosis or treatment.”

And here is the article in question:

Environmental toxins, medications, nicotine, alcohol, unhealthy food – the human body is burdened daily by many substances, waste products and toxins. It is therefore sensible and beneficial to detoxify the liver regularly – preferably naturally. With these homeopathic remedies, this can be done gently.

To stay healthy or to prevent acute diseases from becoming chronic: The reasons to regularly rid the body of accumulated toxins are many. Toxins and waste products weaken the organism or can even cause illness themselves. Especially after drug treatments with antibiotics or cortisone, with frequently recurring colds and flu-like infections, it can be useful to detoxify the body naturally – with homeopathy.

In the body, the liver is the central organ where toxins are broken down. The kidneys, as organs of elimination, also play an important role in detoxification. To support the liver and kidneys in natural detoxification, various medicines are available. In homeopathy, detoxification is also called elimination.

Homeopathic medicines particularly suitable for the detoxification cure:

Sulfur: This classic homeopathic medicine has a strong detoxifying effect on connective tissue and mucous membranes, as well as a cleansing effect on the entire organism. In homeopathy, sulfur is mainly used for natural detoxification after drug treatments with antibiotics and cortisone. If the body is so heavily burdened with waste products that other homeopathic medicines have no effect, Sulfur can be used for natural detoxification.

Nux vomica: A very versatile homeopathic medicine is Nux vomica. It is particularly suitable for detoxifying the body naturally when one has consumed too many stimulants such as coffee or alcohol. It can also be used to eliminate harmful substances caused by medication. Nux vomica has proven particularly useful for the accompanying treatment of side effects after chemotherapy.

Pulsatilla: In homeopathy, Pulsatilla is considered an important natural remedy for detoxification, acting primarily on the mucous membranes and the stomach and intestines. Pulsatilla helps alleviate physical discomfort caused by eating too fatty, unhealthy foods, drinks that irritate the stomach such as coffee and alcohol, and taking medications. Pulsatilla works similarly to the detoxification classic sulfur, only the natural detoxification of liver and kidneys as well as connective tissue proceeds even more gently.

Arsenicum album: Within homeopathy, the remedy Arsenicum album is considered a universal remedy for poisoning, for example by heavy metals. It is mainly used for physical signs of exhaustion and weakness and can compensate for negative consequences of unhealthy nutrition. In addition, Arsenicum album is also said to have an anxiety-relieving effect.

Okoubaka: Okoubaba is also considered a medicine with a strong detoxifying effect, acting mainly on the gastrointestinal tract and used for abdominal cramps, flatulence, constipation, as well as acute diarrhea. Especially after a treatment with antibiotics or after having gone through an illness with norovirus, rotavirus or salmonella, Okoubaba can help to detoxify naturally and restore the intestinal flora.

Magnesium fluoratum: When cold symptoms such as cough and cold flare up again and again after administration of fever-reducing medications and other cold preparations, recovery is protracted and the body is weakened, natural detoxification with magnesium fluoratum can help.

Echinacea: Echinacea is known to increase the body’s defenses. As a homeopathic medicine, it can also help to naturally detoxify underlying conditions that have not been cured.

Detoxify naturally: Typical potencies and their dosage
Low potencies from D3 to D12 are commonly used for self-treatment in natural detoxification. However, choosing the right homeopathic remedy is not always easy. If there are uncertainties, an experienced homeopath should be asked for advice, if possible, in order to determine the drug, potency and dosage on the basis of a detailed anamnesis.

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Impressed?

No?

But I am – though not in a positive sense.

The article contains far too many unsubstantiated statements to mention. In fact, they are not just unsubstantiated, they are false! As the author does not even attempt to provide evidence for them, one cannot even dispute it. Suffice to say that ‘detox’ is BS and homeopathy too. And in healthcare ‘minus X minus’ does sadly not give ‘plus’.

What renders this otherwise trivial article rather important, in my view, is this: such web-based information is not the exception; quite the opposite: German consumers are bombarded with BS of this type.

Ever wondered why Germany is such a huge market for health fraud?

Now you know the answer!

 

 

 

It has been reported that Goop founder Gwyneth Paltrow now has taken to promoting the weirdest wellness thing she’s ever done: rectal ozone therapy. ‘I have used ozone therapy, rectally. Can I say that?’ she told Dear Media podcast The Art of Being Well. ‘It’s pretty weird. It’s pretty weird, yeah. But it’s been very helpful.’

The benefits of rectal ozone therapy are said to be reduced pain/inflammation, increased energy, improved metabolism/circulation, stimulated immune system, detoxification, anti-aging, and fighting bacterial/viral infections.

But who am I to criticize an authority like Gwyneth?

Therefore, I better look up the evidence! And if you had speculated that there is none, you would have been mistaken. Here are some of the more recent clinical studies listed in Medline:

No1:

Objective: Fibromyalgia is a chronic disorder with a very complex symptomatology. Although generalized severe pain is considered to be the cardinal symptom of the disease, many other associated symptoms, especially non-restorative sleep, chronic fatigue, anxiety, and depressive symptoms also play a relevant role in the degree of disability characteristic of the disease. Ozone therapy, which is used to treat a wide range of diseases and seems to be particularly useful in the treatment of many chronic diseases, is thought to act by exerting a mild, transient, and controlled oxidative stress that promotes an up-regulation of the antioxidant system and a modulation of the immune system. According to these mechanisms of action, it was hypothesized that ozone therapy could be useful in fibromyalgia management, where the employed therapies are very often ineffective.

Patients and methods: Sixty-five patients with fibromyalgia, according to the definition of the American College of Rheumatology (Arthritis Rheum 1990; 33: 160-172), were treated at the MEDE Clinic (Sacile, Pordenone, Italy) from February 2016 to October 2018. Females were 55 and males were 10; age ranged from 30 to 72 years, and the time from fibromyalgia diagnosis ranged from 0.5 to 33 years. Treatment was made by autohemotransfusion in 55 patients and by ozone rectal insufflations in 10 patients, according to SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, twice a week for one month and then twice a month as maintenance therapy.

Results: We found a significative improvement (>50% of symptoms) in 45 patients (70%). No patient reported important side effects. In conclusion, at our knowledge, this is the largest study of patients with fibromyalgia treated with ozone therapy reported in the literature and it demonstrates that the ozone therapy is an effective treatment for fibromyalgia patients without significant side effects.

Conclusions: At the moment, ozone therapy seems a treatment that, also because without any side effect, is possible to be proposed to patients with fibromyalgia that are not obtaining adequate results from other available treatments and it can be considered as complementary/integrative medicine.

No2:

Introduction: The Corona virus disease 19 (COVID-19) has accounted for multiple deaths and economic woes.While the entire medical fraternity and scientists are putting their best feet forward to find a solution to contain this deadly pandemic, there is a growing interest in integrating other known alternative therapies in to standard care. This study is aimed at evaluating the safety and efficacy of ozone therapy (OT), as an adjuvant to the standard of care (SOC).

Methods: In the current randomized control trial, 60 patients with mild to moderate score NEWS score were included in two parallel groups (n = 30/group). The interventional group (OZ) received ozonized rectal insufflation and minor auto haemotherapy, daily along with SOC, while the control group (ST) received SOC alone. The main outcome measures included changes in clinical features, oxygenation index (SpO2), NEWS score, Reverse transcription polymerase chain reaction(RT-PCR), inflammatory markers, requirement of advanced care, and metabolic profiles.

Results: The OZ group has shown clinically significant improvement in the mean values of all the parameters tested compared to ST Group. However, statistical significance were only observed in RT-PCR negative reaction (P = 0.01), changes in clinical symptoms (P < 0.05) and requirement for Intensive care (P < 0.05). No adverse events were reported in OZ group, as against 2 deaths reported in ST group.

Conclusion: OT when integrated with SOC can improve the clinical status and rapidly reduce the viral load compared to SOC alone, which facilitate early recovery and check the need for advanced care and mortality as demonstrated in this study.

No 3:

Introduction: IgA deficiency is a primary immunodeficiency predominantly due to an antibody defect, for which there is no replacement therapy. Treatment consists of prevention and treatment of infections and other associated conditions. Given the immunomodulatory and regulatory properties of the redox balance of ozone therapy in infectious and inflammatory conditions, evaluation of its effect on IgA deficiency is of interest.

Objective: Assess the benefits and possible adverse effects of ozone treatment in patients with IgA deficiency.

Methods: A monocentric randomized controlled phase 2 clinical trial (RPCEC 00000236) was carried out, after approval by the Institutional Ethics Committee of the Roberto Rodríguez Fernández Provincial General Teaching Hospital in Morón, Ciego de Ávila Province, Cuba. Included were 40 patients aged 5-50 years, distributed in 2 groups of 20, after agreeing to participate and signing informed consent. The experimental group received 2 cycles of ozone by rectal insufflation for 20 days (5 times a week for 4 weeks each cycle) with a 3-month interval between cycles, for a total of 40 doses, with age-adjusted dose ranges. The control group was treated with leukocyte transfer factor (Hebertrans), 1 U per m2 of body surface area subcutaneously, once weekly for 12 weeks. Frequency of appearance and severity of clinical symptoms and signs of associated diseases, serum immunoglobulin concentrations and balance of pro-oxidant and antioxidant biomarkers were recorded at treatment initiation and one month after treatment completion. Therapeutic response was defined as complete, partial, stable disease or progressive disease. Descriptive statistics and significance were calculated to compare groups and assess effect size.

Results: One month after treatment completion, 70% of patients in the experimental group experienced significant increases in IgG(p = 0.000) and IgM (p = 0.033). The experimental group also displayed decreased pro-oxidation biomarkers, glutathione modulation and increased antioxidant enzymes, with reduced oxidative stress; none of these occurred in the control group. Complete therapeutic response was achieved in 85% of patients in the experimental group and only 45% in the control group. Mild, transient adverse events were reported in both groups.

Conclusions: Ozone therapy by rectal insufflation is a suitable therapeutic option for treating IgA deficiency because it produces antioxidant and immunomodulatory effects and is feasible, safe and minimally invasive.

No 4:

Background: Ozone therapy may stimulate antioxidant systems and protect against free radicals. It has not been used formerly in patients with pulmonary emphysema.

Aim: To assess the effects of rectal ozone therapy in patients with pulmonary emphysema.

Material and methods: Sixty four patients with pulmonary emphysema, aged between 40 and 69 years, were randomly assigned to receive rectal ozone in 20 daily sessions, rectal medicinal oxygen or no treatment. Treatments were repeated three months later in the first two groups. At baseline and at the end of the study, spirometry and a clinical assessment were performed.

Results: fifty patients completed the protocol, 20 receiving ozone therapy, 20 receiving rectal oxygen and 10 not receiving any therapy. At baseline, patients on ozone therapy had significantly lower values of forced expiratory volume in the first second (fEV1) and fEV1/forced vital capacity. At the end of the treatment period, these parameters were similar in the three treatment groups, therefore they only improved significantly in the group on ozone therapy. No differences were observed in other spirometric parameters.

Conclusions: Rectal ozone therapy may be useful in patients with pulmonary emphysema.

No 5:

Background: Pain secondary to chemotherapy-induced peripheral neuropathy (CIPN) can limit the administration of chemotherapy, cancer-treatment outcomes, and the quality of life of patients. Oxidative stress and inflammation are some of the key mechanisms involved in CIPN. Successful treatments for CIPN are limited. This report shows our preliminary experience using ozone treatment as a modulator of oxidative stress in chronic pain secondary to CIPN. Methods: Ozone treatment, by rectal insufflation, was administered in seven patients suffering from pain secondary to grade II or III CIPN. Pain was assessed by the visual analog scale (VAS). Results: All patients, except one, showed clinically relevant pain improvement. Median pain score according to the VAS was 7 (range: 5-8) before ozone treatment, 4 (range: 2-6) at the end of ozone treatment (p = 0.004), 5.5 (range: 1.8-6.3) 3 months after the end of ozone treatment (p = 0.008), and 6 (range: 2.6-6.6) 6 months after the end of ozone treatment (p = 0.008). The toxicity grade, according to the Common Terminology Criteria for Adverse Events (CTCAE v.5.0), improved in half of the patients. Conclusion: This report shows that most patients obtained clinically relevant and long-lasting improvement in chronic pain secondary to CIPN after treatment with ozone. These observed effects merit further research and support our ongoing randomized clinical trial.

No 6:

Background: Medical ozone is more bactericidal, fungicidal, and virucidal than any other natural substance. Some studies proved that ozone infused into donated blood samples can kill viruses 100% of the time. Ozone, because of its special biologic properties, has theoretical and practical attributes to make it a potent hepatitis C virus (HCV) inactivator, which suggests an important role in the therapy for hepatitis C.

Aim: The study aim is to evaluate the role of ozone therapy in decreasing HCV ribonucleic acid (HCV RNA) load and its effect on the liver enzymes among patients with chronic hepatitis C.

Methods: This study included 52 patients with chronic hepatitis C (positive polymerase chain reaction [PCR] for HCV RNA and raised serum alanine transaminase [ALT] for more than 6 months). All patients were subjected to meticulous history taking and clinical examination. Complete blood count, liver function tests, and abdominal ultrasonography were requested for all patients. The ozone group included 40 patients who received major autohemotherapy, minor autohemotherapy, and rectal ozone insufflation. The other 12 patients (conventional group) received silymarin and/or multivitamins.

Results: There were significant improvements of most of the presenting symptoms of the patients in the ozone group in comparison to the conventional group. ALT and aspartate transaminase (AST) levels normalized in 57.5% and 60% in the ozone group, respectively, in comparison to 16.7% and 8% in the conventional group, respectively. Polymerase chain reaction (PCR) for HCV RNA was negative among 25% and 44.4% after 30 and 60 sessions of ozone therapy, respectively, in comparison to 8% among the conventional group.

Conclusions: Ozone therapy significantly improves the clinical symptoms associated with chronic hepatitis C and is associated with normalized ALT and AST levels among a significant number of patients. Ozone therapy is associated with disappearance of HCV RNA from the serum (-ve PCR for HCV RNA) in 25%-45% of patients with chronic hepatitis C.

No 7:

Oxidative stress is suggested to have an important role in the development of complications in diabetes. Because ozone therapy can activate the antioxidant system, influencing the level of glycemia and some markers of endothelial cell damage, the aim of this study was to investigate the therapeutic efficacy of ozone in the treatment of patients with type 2 diabetes and diabetic feet and to compare ozone with antibiotic therapy. A randomized controlled clinical trial was performed with 101 patients divided into two groups: one (n = 52) treated with ozone (local and rectal insufflation of the gas) and the other (n = 49) treated with topical and systemic antibiotics. The efficacy of the treatments was evaluated by comparing the glycemic index, the area and perimeter of the lesions and biochemical markers of oxidative stress and endothelial damage in both groups after 20 days of treatment. Ozone treatment improved glycemic control, prevented oxidative stress, normalized levels of organic peroxides, and activated superoxide dismutase. The pharmacodynamic effect of ozone in the treatment of patients with neuroinfectious diabetic foot can be ascribed to the possibility of it being a superoxide scavenger. Superoxide is considered a link between the four metabolic routes associated with diabetes pathology and its complications. Furthermore, the healing of the lesions improved, resulting in fewer amputations than in control group. There were no side effects. These results show that medical ozone treatment could be an alternative therapy in the treatment of diabetes and its complications.

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What does that tell us?

That rectal ozone therapy is a panacea?

No, I don’t think so.

In my view, it tells us that strange journals publish a lot of dodgy research from strange research groups that use dodgy methodologies to confirm their odd belief that bogus treatments work for everything.

PS

I wonder which orifice Gwyneth will employ next to get the attention of the public.

Yesterday, it has been reported that Indian scientists found the mode of action of homeopathic remedies. This is the newspaper article:

And this seems to be the abstract of the actual paper:

Homeopathic medicines contain ultra-low concentrations of metal and compounds, and it is challenging to classify homeopathic potencies using modern characterization tools. This work presents a novel experimental tool for classifying various homeopathic medicines under a low-frequency generated electromagnetic (EM) fields. A custom-built primary coil is used for generating EM fields at different excitation frequencies. The potentized test samples were prepared at decimal dilution scale of Ferrum with α‑lactose monohydrate and exhibited significant and distinct induced EM responses in the second sensing coil. The measured responses decrease logarithmically due to reducing Ferrum concentration. The resolution improved in higher potencies from 0.03 µV at 300 Hz to 0.24 µV at 4.8 kHz. Different compounds of homeopathic medicines were also investigated to produce distinct induced EM characteristics. These results were correlated with Raman spectroscopy, impedance analyser, and FT-IR analysis. The experimental investigation confirmed the classification of potencies and the technique developed to detect ultra-low metallic concentrations.

I might be a bit slow on the uptake – but I don’t see how this investigation proves anything. Perhaps someone can explain it to me?

So-called alternative medicine (SCAM) is widely used in Arabia. One of the commonly used methods is camel urine alone or mixed with camel milk. Camel urine is a liquid by-product of camel metabolism. Urine from camels has been used as prophetic medicine for centuries, being a part of ancient Bedouin practices. Camel urine comes out as a concentrated, viscous syrup because the kidneys and intestines of a camel are very efficient at reabsorbing water.

Camel urine is consumed and used for treating numerous ailments. Some employ it as a treatment for hair loss, for instance. The camel urine from a virgin camel is priced at twenty dollars per liter, with herders saying that it has curative powers.

A recent paper offers more information:

Camel is one of the important livestock species which plays a major role in the pastoral mode of life by fulfilling basic demands of livelihood. Traditionally, camel urine has been used in the treatment of human diseases. With regard to the health benefits of drinking the urine of camels, it has been proven by modern scientific researches. Camel urine has an unusual and unique biochemical composition that contributes to medicinal values. The chemical composition of camel urine showed the presence of purine bases, hypoxanthine, sodium, potassium, creatinine, urea, uric acid, and phosphates. The nano-particles in the camel’s urine can be used to fight cancer. Camel urine has antimicrobial activity against pathogenic bacteria. Its chemical and organic constituents have also inhibitory properties against fungal growth, human platelets, and parasitic diseases mainly fasciollosis in calves. The healthy status of the liver can be restored through ingestion of diet and minerals in camel urine. Camel urine is used by the camel owners and Bedouins as medicine in different ways. The Bedouin in the Arab desert used to mix camel urine with milk. Recently; the WHO has warned against drinking camel urine due to the modern attempt to limit Outbreaks of Respiratory Syndrome (MRS) in the Middle East. There is no scientific dosage for camel urine to be applied as medicine for different diseases and the ways of camel urine formulation and utilization for the care of patients varies from country to country. Therefore, the purposes of the present review describe the biochemical composition of camel urine will be scientifically extracted and formulated as a therapy rather than drinking raw urine and people’s health impact.

Researchers from the Medical Oncology Department, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia wanted to determine whether camel urine shows promise in the treatment of cancer. The aim of their study was to observe cancer patients who insisted on using camel urine and to devise some clinically relevant recommendations.

The authors observed 20 cancer patients (15 male, 5 female) from September 2020 to January 2022 who insisted on using camel urine. They documented the demographics of each patient, the method of administering camel urine, the reasons for refusing conventional treatment, the period of follow-up, and the outcome and side effects.

All the patients had radiological investigations before and after finishing treatment with camel urine. All patients used a combination of camel urine and milk, and treatment ranged from a few days up to 6 months. The average amount of urine/milk consumed was 60 ml/day. No clinical benefit was observed and two patients developed brucellosis. Eleven patients changed their minds and eventually accepted conventional antineoplastic treatments but 7 were too weak to receive further treatment and died from their disease.

The authors concluded that camel urine had no clinical benefits in cancer patients, and may even have caused zoonotic infection. The promotion of camel urine as a traditional medicine should be stopped because there is no scientific evidence to support it.

I fear that, yet again, ‘ancient wisdom’ turns out to be just ‘old bullshit’.

It has been reported that King Charles refused to pay Prince Andrew’s £ 32,000-a-year bill for his personal healing guru. The Duke of York has allegedly submitted the claim to the Privy Purse as a royal expense having sought the help of a yoga teacher.

However, the claim has reportedly been denied by the King, who is said to have told Andrew the bill will need to be covered using his own money. It comes after sources claimed Andrew has been using the Indian yogi for a number of years for chanting, massages, and holistic therapy in the privacy of his mansion. The healer has reportedly enjoyed month-long stays at a time at the £30 million Royal Lodge in Windsor.

Previously, the Queen seems to have passed the claims. But now Charles is in control. A source said: “While the Queen was always happy to indulge her son over the years, Charles is far less inclined to fund such indulgences, particularly in an era of a cost-of-living crisis. “Families are struggling and would rightly baulk at the idea of tens of thousands paid to an Indian guru to provide holistic treatment to a non-working royal living in his grace and favour mansion. This time the King saw the bill for the healer submitted by Andrew to the Privy Purse and thought his brother was having a laugh.”

________________________

Poor Andrew!

How is he going to cope without his guru?

Will he be able to recover from the mysterious condition that prevents him to sweat?

Will his ego take another blow?

How will he be able to afford even the most basic holistic wellness?

How can Charles – who knows only too well about its benefits – be so cruel to his own brother?

Should I start a collection so that Andrew can pay for his most basic needs?

____________________________

Yes, these are the nagging questions and deep concerns that keep me awake at night!

 

 

PS

I have just been asked if, by any chance, the yoga teacher is a 16-year-old female. I have to admit that I cannot answer this question.

 

I have grumbled about prevalence surveys in so-called alternative medicine (SCAM) before, I know. But, as the problem continues to get on my nerves – I estimate that there are about 10 times more surveys in SCAM than in any other field – allow me to do it again. The subject appeared on my screen in the form of a recent article from a minor, not Medline-listed journal. The paper is entitled:

Investigation of Complementary and Alternative Medicine Use in Turkish Patients with Epilepsy

This type of prevalence survey is typical of its genre and stands for hundreds – thousands even – like it. Its findings reveal a high prevalence of use. From that result, enthusiasts tend to draw stereotypical conclusions, namely that we need more research and that we ought to consider the integration of SCAM into routine care.

WHAT A WASTE OF TIME AND EFFORT!

Who really needs to know how many epilepsy patients in Turkey use SCAM?

Nobody!

You disagree?

Fine, then tell me: why Turkey and why epilepsy? If such information were important (and the methodology of the survey were perfect [which it hardly ever is]), then we surely need it for all diseases. How many different diseases are there? Let’s make it easy and say 1000. This means we need 1000 surveys to obtain a valuable picture of SCAM use in Turkey.

And if this sort of information is relevant in Turkey, we need to have it also for all other major countries. How many major countries exist? Let’s make it simple again and say 500. This means that we need 500 x 1000 or 500 000 surveys to generate a meaningful picture of SCAM use.

Since SCAM use changes quickly, we require these articles to be updated regularly; let’s say every 3 years. That means we require half a million surveys every 3 years.

What for?

What would it tell us?

What would we conclude from this enormous body of research?

Yes, of course, we would conclude that we need more research and we ought to consider the integration of SCAM into routine care!

My point is that if we truly need more research, why not get on with it? Why not finally forget about such useless surveys and do the science? Why not determine which SCAM works for what condition and at what risks? And, in case the findings turn out to be positive [but only then], let’s talk about integration into routine care. To put it even blunter:

The survey mania in SCAM prevents progress.

 

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