herbal medicine
An interesting case-report caught my eye. Here is its abstract:
Background:
Advanced Alzheimer’s disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking.
Case presentation:
We report the case of an octogenarian Japanese-American woman with a 10-year history of Alzheimer’s disease, including 5 years of marked hypofunction and predominantly monosyllabic speech. Baseline features included chronic urinary incontinence, executive dysfunction, dysphagia, dependent mobility, flat affect, and severe reduction in spontaneous communication. The patient received 5 g of orally administered psilocybin-containing mushrooms (Enigma strain). The acute phase was marked by autonomic activation, clinically suspected hyperthermia, profuse sweating, and a prolonged deep sleep-like state. Approximately 19 h post-administration, spontaneous autobiographical speech emerged. Over subsequent days and weeks, functional improvements included restoration of urinary continence, improved ambulation, autonomous dressing, increased emotional responsiveness, sustained social interaction, contextual memory retrieval, preserved working memory for social context, and spontaneous conversational engagement.
Conclusion:
This case documents transient multidomain functional improvement in advanced Alzheimer’s disease following psilocybin administration. The findings do not imply disease reversal but suggest that residual functional capacity may persist in late-stage neurodegeneration and may become transiently accessible under specific neuromodulatory conditions.
Of course, causality cannot be established with a case-report; the findings are therefore hypothesis-generating only. Plausible alternative explanations for the observed outcome include:
- Natural fluctuation in dementia severity or a transient “plateau” of improvement unrelated to psilocybin.
- Caregiver expectancy and observer bias, given that the same people who administered the intervention also documented the improvements.
- Confounding medical events (e.g., resolution of infection, metabolic correction, medication change) that were not systematically ruled out.
- Regression to the mean or random variation in functional status.
The lack of an objective endpoint (biomarker or imaging confirmation) of Alzheimer’s disease further weakens internal validity. Mixed pathology (vascular, Lewy body, frontotemporal) could produce different patterns of fluctuation and response. The absence of objective endpoints introduces subjective interpretation. “Autobiographical speech,” “improved continence,” and “better mobility” were not defined operationally or measured quantitatively.
The authors propose a plausible but speculative hypothesis: psilocybin’s disruption of the default mode network (DMN) and promotion of global functional integration may temporarily restore cross-network connectivity, allowing residual but inaccessible function to become expressed. This is consistent with psychedelic effects on network flexibility and DMN disruption, as well as with the idea that late-stage neurodegeneration may leave residual functional capacity that is normally inaccessible. However, the paper provides no neuroimaging, no electrophysiological data, and no direct evidence of network changes. The mechanism thus remains a hypothesis.
Still, the report does raise a question worthy of proper investigation: can psychedelic neuromodulation unmask residual function in late-stage neurodegeneration?
The Nazi’s sterilisation programme aimed at preventing Germans from reproducing who were deemed to be of inferior genetic make-up. It is well-known, and dozens of books have been published about it. In contrast, the ‘LEOPARD LILY PROJECT’ has been almost forgotten. Even though it also was about sterilising large groups of people, it had a very different overall aim.
The porject can be traced back to an Austrian dermatologist named Dr. Adolf Pokorny. Pokorny had encountered a scientific paper detailing animal experiment involving Dieffenbachia seguine (commonly known as the Leopard Lily or “dumb cane”). The juice of this tropical plant could be administered secretly to nonconsenting victims and was assumed to cause permanent sterility without affecting the capacity to work.
Pokorny recognized the dark potential of this botanical property. In his letter to Himmler, he explicitly proposed using Leopard Lily to secretly sterilize “three million Bolsheviks” and other populations in Eastern Europe. Pokorny’s vision was calculated and ruthless: by rendering the inhabitants of occupied territories infertile, the Third Reich could exploit them as slave labour for a single generation. Once that generation aged and died, the population would naturally become extinct, leaving the land cleared for German colonization.
The primary reason this unproven botanical theory was taken seriously at the highest levels of the Nazi command rests on the unique obsessions of Heinrich Himmler. The SS leader was deeply fascinated by alternative medicine, occultism, and pseudoscience. He harboured an intense distrust of mainstream academic medicine and actively promoted natural, herbal remedies.
Captivated by Pokorny’s letter, Himmler bypassed conventional, rigorous scientific channels, assigning high-ranking SS bureaucrats and doctors to fast-track the cultivation of the plant and initiate medical experimentation. However, to operationalize the project, the SS faced an immediate bottleneck: Leopard Lily is native to tropical climates, and Himmler did not possess enough of the plant to extract toxins at a mass scale. Huge, specialized greenhouses were commissioned, and efforts were made to cultivate the plant under controlled conditions within Germany. Yet, the project collapsed under the weight of its own scientific flaws and the changing tides of World War II. The plant could not be grown in quantities large enough to fulfil Himmler’s genocidal dream.
Following the collapse of the Third Reich, the details of the project were brought to light during the Nuremberg Doctors’ Trial (1946–1947). Dr. Adolf Pokorny was placed in the dock alongside prominent Nazi medical war criminals. Pokorny was one of the few to be acquitted by the tribunal. What then became of him remains a mystery.
The very last paragraph of my new book reads as follows: “The story of the Leopard Lily project can serve as a reminder of the dangers caused by unholy alliances of pseudoscience, ideology, immorality, and political power. These dangers have not ended with the Third Reich. If the book can contribute to reducing the risks of future recurrences, it was worth the effort of writing it.”
In the realm of so-called alternative medicine (SCAM), “chemical” has long been a dirty word. This phenomenon, known as chemophobia – an irrational fear of synthetic substances – drives a multi-billion-dollar industry obsessed with the “all-natural.” While it stems from an understandable desire for safety (and for making money out of the fear of the public), the chemophobia of SCAM relies on a fundamental misunderstanding of basic chemistry and toxicology, building a false dichotomy between wholesome nature and malicious chemistry.
To truly dismantle this anxiety, one needs to look no further than a perfect example from nature: the humble apple. If an organic, all-natural apple were required to carry an ingredient label written by a chemist, it would look far more intimidating than any processed food label. A single bite of an apple delivers a complex cocktail of chemical compounds. Beyond its bulk structure of water, dietary pectin, and sugars like fructose and sucrose, an apple is a dense matrix of amino acids—including glutamic acid, aspartic acid, and tyrosine—and fatty acids like linoleic and palmitic acid. It is enriched with vitamins and minerals, from ascorbic acid and alpha-tocopherol to potassium and magnesium. Even its delightful aromas and flavors are synthesized by nature using a mixture of volatile organic compounds: esters like butyl acetate, alcohols like hexan-1-ol, aldehydes like trans-2-hexenal, and a sharp dose of malic acid. More surprisingly perhaps, this wholesome fruit features nature’s own “toxins.” Apples naturally contain trace amounts of formaldehyde, and their seeds contain amygdalin, a cyanogenic glycoside that degrades into deadly hydrogen cyanide when digested.
The chemical reality of this simple apple highlights the core fallacy of chemophobia: the belief that natural compounds are inherently safe, while synthetic ones are unavoidably toxic. In reality, nature is a master chemist, and the foundational rule of toxicology dictates that it is mostly the dose that makes the poison. Anything can be toxic in excess—even water—and many synthetic molecules are identical to, or safer than, their natural counterparts. Aspirin, for instance, has less side-effects that an extract of willow bark!
The chemophobia of SCAM proponents strips away all nuance and treats the mere presence of a complicated chemical name as an absolute hazard. By fostering a deep-seated distrust of science, it steers ill-informed individuals away from life-saving conventional treatments towards unproven quackery. True health literacy requires moving past misleading branding and recognising that everything in our universe, from a crisp apple to a synthetic antibiotic, is made of chemicals.
So-called alternative medicine (SCAM) likes to present itself as a champion of disease prevention. Its advocates routinely claim to promote health before disease develops, to strengthen the body’s defences, and to address root causes rather than symptoms. This rhetoric is highly attractive, because prevention sounds proactive, humane, and economical. Crucially, it is also good for the SCAM practitioner’s bank account. Yet there is a snag: almost none of the preventive claims made for SCAM are supported by reliable evidence, whereas the prevention that works comes overwhelmingly from conventional medicine and science.
To show preventive benefit, an intervention must demonstrably reduce the incidence of symptom, disease, complication, or mortality in properly designed studies. That may require randomised trials, epidemiological studies, large cohorts, reproducible findings, and enough follow-up to show that fewer people actually experienced the given endpoint. Mainstream medicine has repeatedly met this standard. Immunization, blood pressure control, smoking cessation, lipid lowering, cancer screening, and risk-factor modification are all products of biomedical research, not of alternative healing traditions.
SCAM, by contrast, tends to use prevention in a loose, impressionistic, and unfalsifiable way. A practitioner may claim that a treatment “balances energy,” “supports immunity,” or “keeps the body in harmony,” but such phrases do not establish a preventive effect. They are placeholders for evidence, not evidence itself. In practice, the absence of disease after treatment is treated as proof that the treatment worked, even though the same outcome occurs every day without any intervention at all.
Acupuncture is a good example. Its defenders portray it as a preventive system capable of preserving general health or warding off illness, but the evidence base does not support that claim. Some reviews do suggest that acupuncture may help with some pain-related and symptom-focused conditions, yet its preventive value is largely unproven. I am not aware of solid evidence to show that acupuncture prevents anything – but, if I am wrong, please do correct me.
Chiropractic care is even more revealing because preventive claims are often tied to the doctrine of spinal “subluxation” and nervous system dysfunction. Yet the literature on prevention is thin and methodologically weak. I am not aware of solid evidence to show that chiropractic prevents anything – but, if I am wrong, please do correct me.
Herbalism benefits from the romantic appeal of “natural” remedies, but that appeal should not be confused with demonstrated preventive efficacy. Individual plant compounds have certainly inspired real drugs, yet that is a triumph of pharmacology, not of herbalism as a system. When herbal medicines are tested for prevention, results are usually weak, inconsistent, or insufficient to support recommendation. I am not aware of solid evidence to show that herbal medicine prevents anything – but, if I am wrong, please do correct me.
Homeopathy is one of the most extreme cases within SCAM. It is often sold as gentle, individualized, and even preventive, but its basic principles are scientifically implausible, and its clinical evidence is either flawed or negative. Preventive homeopathy, including ideas such as “homeoprophylaxis,” is particularly problematic because it can give people a false sense of security while displacing interventions that genuinely prevent disease, such as vaccination. I am not aware of solid evidence to show that homeopathy prevents anything – but, if I am wrong, please do correct me.
SCAM speaks almost constantly about prevention, but the evidence for actual preventive benefit is close to non-existent. What we know about prevention, what truly reduces disease incidence and improves population health, comes from conventional medicine, epidemiology, public health, and biological science. SCAM will no doubt continue to borrow the language of medicine and prevention, but – as far as I can see – it has failed to supply the proof.
On May 27, 2026, the U.S. Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) announced they are investigating a 3rd multistate outbreak of Salmonella infections linked to moringa powder supplements in 2026. Moringa oleifera supplements (including green powders and capsules) are heavily marketed as a “superfood” and a natural multivitamin powerhouse. They are primarily promoted for:
- Nutritional Support: Providing high concentrations of protein, iron, calcium, and vitamins A, C, and E.
- Energy & Metabolism: Boosting daily vitality and supporting healthy weight management.
- Blood Sugar & Heart Health: Helping to regulate glucose levels, lower cholesterol, and manage blood pressure.
- Immune & Inflammation Support: Using rich antioxidant content (like quercetin) to combat cellular stress and ease joint pain or chronic inflammation.
The agencies re-opened an outbreak investigation originally closed on March 17 after discovering 22 new illnesses from 4 US states. The total now stands at 119 patients across 36 states infected with Salmonella Typhimurium or Salmonella Newport strains, including 32 hospitalizations and no deaths. Illness onset dates range from August 22, 2025, to April 26, 2026.
Among 79 interviewed patients, 70 reported consuming moringa leaf powder products. The recalled product list expanded to include TNvitamins-brand Ultra Potent Complete Green Superfood Moringa capsules and Doctor’s Pride Complete Green Superfood Ultra Potent Moringa capsules distributed by Total Nutrition Inc., plus Why Not Natural Pure Organic Moringa capsules and All Live it Up-brand Super Greens dietary supplement powders.
The new investigation involves Salmonella Typhimurium infections linked to MOGO-brand moringa powder capsules distributed by MOGO Moringa LLC of St. Louis. 18 people infected with the outbreak strain have been reported from 14 states, with illness onset from February 3 to April 7, 2026. Of 8 interviewed individuals, 6 reported consuming moringa powder capsules, including 4 who specifically consumed MOGO-brand products. Seven hospitalizations occurred with no deaths reported. MOGO Moringa LLC has recalled specific lots (#15525AA EXP 6/2027 and #00926AA EXP 1/2028) of MOGO-brand Pure Moringa Oleifera capsules. The FDA is conducting traceback investigations to identify the contamination source and working with state partners to collect samples.
In April 2026, the FDA closed a separate outbreak investigation involving moringa supplements contaminated with “extensively drug-resistant” Salmonella. This outbreak linked to Rosabella-brand moringa powder capsules distributed by Ambrosia Brands LLC resulted in seven illnesses across seven states, with three hospitalizations.
Three moringa-related outbreaks in a single year underscore systemic issues affecting botanical ingredients in the global natural health industry, particularly regarding imported moringa leaf powder contamination. Health officials urge consumers who used moringa products and developed symptoms – diarrhea, abdominal cramps, fever within 12-72 hours – to seek medical attention and inform doctors about potential Salmonella exposure. Healthy adults typically remain ill for 4-7 days. Severe diarrhea may require hospitalization.
Update, 7/6/26:
Following the May 27, 2026, announcements, Total Nutrition Inc. expanded its voluntary recall on June 2 to include Lot 2748 (Exp. 07/2027) for both TNVitamins and Doctor’s Pride brands after a traceability review linked it to previously contaminated raw materials. Meanwhile, the active investigation into MOGO-brand capsules remains unchanged with 18 reported illnesses, and the FDA continues to urge consumers to check their pantries for any remaining Rosabella-brand products from the closed April outbreak. Federal and state health officials are actively working with major online platforms—including Amazon, Walmart, and TikTok Shop—to ensure all recalled moringa supplements are fully removed from the market, while reminding consumers to seek medical care if they experience Salmonella symptoms.
The case of the 14-year-old girl who died of cancer is now occupying the Klagenfurt Regional Court for the second time. The girl’s parent elected to trust miracle healers and esoteric practitioners. Ultimately, the 14-year-old arrived at the hospital far too late—the cancer was already so advanced that the girl died less than two days later.
The parents have already been convicted of torture and neglect. During their criminal trial, the doctor came into the prosecution’s focus. He had administered four infusions of “cat’s claw” to the 14-year-old. The doctor admitted to this last year during his testimony as a witness, where he raved about the “miracle plant” cat’s claw, claiming it could heal almost anything.
He was also accused of using a pendulum to “test” the girl’s tumor and certifying it as benign. His response at the time was that he does not use a pendulum; rather, he had “dowsed” the tumor using a biotensor—a small metal spring. He claimed that when he failed to get a clear result, he urgently recommended the parents seek a biopsy, which they strictly refused. He alleged they eventually broke off treatment with him.
According to the indictment, the doctor is allegedly responsible for a further patient’s death by administering the herbal infusion. The man had collapsed after receiving it, suffered a heart attack and a stroke, and died weeks later from the consequences.
Furthermore, the doctor is accused of “grossly negligently causing a danger to the life and health of at least 6,550 people from May 2007 to May 2025.” Contrary to the standards of medical practice, he is said to have intravenously administered essences that were only approved as food products. The prosecutor referred to an analysis of the infusion solutions: “These were not pure; they contained soil and ash particles.” They were reportedly “brewed together in a backyard” – the contamination, she noted, could lead to the formation of blood clots. During his questioning, the trained intensive care physician rejected all guilt: “I feel in no way responsible.” He stated he had treated numerous cancer patients—for example, with cat’s claw or high-dose vitamin C.
In the case of the 14-year-old, the doctor insisted he was able to “see that something was not right” using the device. He claimed he only learned much later that the parents had canceled a biopsy appointment after their session with him. Furthermore: “Father and daughter always rejected any conventional medical therapy or diagnostics.” He maintained that he always noted his infusions could only boost the immune system and improve well-being, but never promised anything.
Regarding the case of the other deceased man, the doctor argued that the patient had already received 17 infusions from him prior to the incident in question and had always felt better afterward. After the final infusion, the patient felt unwell for a while, but his condition supposedly improved. The doctor claimed it was absolutely not anaphylactic shock: “Otherwise, I wouldn’t have let him go home.”
The defendant questioned each and every expert opinion obtained for the case. Regarding the statement that it is impossible for a tumor to shrink due to his infusions, he said, “I wouldn’t sign off on that.” As for the infusions, he claimed they were filtered multiple times and specially prepared for intravenous use.
A date for this has not yet been set. So, watch this space!
The Indian Ministry of Ayush was established in 2014 with a vision of reviving the profound knowledge of India’s ancient systems of medicine and ensuring the optimal development and propagation of the Ayush systems of healthcare. Earlier, the Department of Indian System of Medicine and Homoeopathy (ISM&H) formed in 1995, was responsible for the development of these systems. It was then renamed as the Department of Ayurveda, Yoga, and Naturopathy, Unani, Siddha and Homoeopathy (Ayush) in November 2003 with focused attention towards education and research in these therapies.
In the global landscape of public health, India’s Ministry of AYUSH stands as a profound anomaly. While most middle‑ and high‑income countries have converged around evidence‑based, scientifically grounded medicine, India has instead expanded this large, state‑run administrative apparatus where cultural nationalism and traditionalist narratives dominates over clinical efficacy and scientific rigor. The Ministry’s current trajectory reveals a troubling pattern: the systematic promotion of unproven therapies, flawed research, and notorious breaches of ethical principles, particularly with respect to the treatment of India’s most vulnerable populations.
The Homeopathy Anomaly
The most glaring anomaly must be the Ministry’s continued, high‑level support for homoeopathy. India is currently the only country in the world that maintains a dedicated national ministry and a statutory regulatory framework – via the National Commission for Homoeopathy – specifically to promote a system widely regarded as implausible, ineffective and harmful. Global assessments, including those by no less than 28 independent organisations worldwide, have concluded that there is no reliable evidence that homeopathic remedies work beyond placebo. Yet the AYUSH Ministry funds and publicizes a central research council (the Central Council for Research in Homoeopathy, CCRH) as well as a network of homoeopathic hospitals and teaching institutions, with annual budget allocations now exceeding ₹4,400 crore (roughly 470–480 million US dollars at current exchange rates). By directing substantial taxpayer funds to homoeopathic research and infrastructure, the state effectively endorses a “placebo‑as‑medicine” model, elevating it to the status of a national health strategy. This is not merely an academic dispute; it is a policy outlier that places India’s healthcare posture at odds with well‑established chemical and physical principles, as well as with the recommendations of leading international scientific bodies.
The Facade of Rigor
The Ministry tends to defend its approach by claiming a pivot toward “evidence‑based” or “scientific” AYUSH medicine, but an examination of its research output suggests a facade of rigor rather than its substance. Much of the work produced by bodies such as the Central Council for Research in Ayurveda (CCRA) and their counterparts in Unani and Siddha consists of investigations that are methodologically weak and wide open to bias. Key methodological flaws recur:
- Small sample sizes: Many trials involve fewer than 50–100 participants, rendering them statistically underpowered.
- Lack of blinding: A large proportion of studies is open‑label, where both clinicians and patients know the assigned intervention, amplifying placebo effects and observational bias.
- Selective reporting and publication bias: Negative findings – where AYUSH interventions fail to demonstrate benefit – are rarely published.
By branding such useless studies as “scientific proof,” the Ministry engages in a form of “science‑washing.” This practice misleads the public, uncritical clinicians, and policymakers into believing that AYUSH therapies have undergone the same rigorous, independent scrutiny as conventional therapies.
The Ethical Violations
In my view, the most serious concern is ethical. Under the banner of “Self‑Reliant India” (Atmanirbhar Bharat), the Ministry has aggressively promoted AYUSH products, for instance, during the COVID‑19 pandemic. This push could be viewed as an exercise in cultural pride and national self‑reliance but, in fact, it carries serious risks.
Medical ethics rely on two core principles: informed consent and non‑maleficence. When a state body, backed by cabinet‑level authority, “flogs” unproven and potentially dangerous treatments to a largely rural population with limited health literacy, it undermines both. Many patients are not able to distinguish between an ancient tradition and a clinically validated drug, yet they may be led by government‑sponsored messaging to defer or abandon evidence‑based treatments.
This is particularly dangerous in chronic conditions such as diabetes mellitus and hypertension, where effective pharmacological control and regular monitoring are both available and potentially life‑saving. If patients substitute proven allopathic regimens with state‑endorsed AYUSH alternatives of uncertain efficacy, the consequences can be dire. They include uncontrolled blood glucose, stroke‑risk elevation, organ damage, and avoidable mortality. The Ministry’s conduct, in effect, offloads these risks onto the most vulnerable while shielding itself behind appeals to tradition and national identity.
Conclusion
The Ministry of AYUSH has become the institutional vehicle for a “pluralistic” health model that, in practice, functions as a state‑funded rejection of the scientific method. This constitutes a regression in public‑health governance rather than a progressive pluralism. Until the Ministry subjects its therapies to the same scrutiny as any other medicine, and until it accepts transparent, independent evaluations without recourse to political or cultural vindication, it will remain less a health body and more a department of cultural preservation and doctrine.
The ‘Smallwood Report‘, entitled “The Role of Complementary and Alternative Medicine in the NHS” was published in October 2005. It recommended greater integration of so-called alternative medicine (SCAM) into the UK’s National Health Service and to address “effectiveness gaps” in treating chronic and psychosocial conditions, claiming potential cost savings.
Its core recommendations were:
- NICE assessment: Urged Health Ministers to task the National Institute for Health and Clinical Excellence (NICE) with a full review of the cost-effectiveness of therapies like acupuncture, chiropractic, osteopathy, herbal medicine, and homeopathy.
- Targeted applications: Suggested these SCAM options for lower back pain (manipulative therapies over conventional), asthma (homeopathy), common colds (echinacea), and other chronic issues where orthodox medicine falls short, potentially reducing absenteeism and NHS costs by hundreds of millions.
- Implementation steps: Promote GP referrals to SCAM, target deprived communities, prioritize research on cost-effectiveness/safety, address regulatory barriers, and use case studies showing reduced GP visits and secondary care savings.
At the time, I called its evidence “grossly misleading,” citing ignored Cochrane reviews showing no superiority for most of the claims. Many critics agreed with me, and the Lancet editor Richard Horton famoulsy called it “dangerous nonsense”.
As the recommendations were pure BS, it is comforting to note that – 20 years later – they have been largely ignored.
NICE assessments:
NICE has issued selective endorsements—e.g., acupuncture and manipulative therapies for low back pain—but stopped short of broad SCAM evaluations, often citing “insufficient evidence” or requiring further trials, directly countering the report’s call for comprehensive cost-effectiveness reviews. No large-scale NICE program emerged to validate the report’s claimed savings (hundreds of millions annually), and guidelines frequently dismiss or deprioritize unproven modalities like homeopathy.
NHS integration status:
- Limited GP referrals: Sporadic pilots exist (e.g., acupuncture in some pain clinics, osteopathy/chiropractic for musculoskeletal issues), often GP-led and adjunctive, but not systematic; social prescribing now favors mindfulness over traditional SCAM.
- Funding barriers: Most Integrated Care Boards (ICBs) classify SCAM as “low priority” absent robust evidence, funding only exceptional cases in palliative or pain management pathways; many services closed due to austerity post-2010.
- No deprived-community focus: The report’s equity push for high-need areas saw negligible uptake, with barriers like clinician resistance and regulatory hurdles persisting.
The report’s optimistic case studies (e.g., Glastonbury) proved anecdotal and unscaled, undermined by critiques highlighting flawed evidence (e.g., ignored Cochrane reviews). Today, NHS policy emphasizes evidence-based conventional care, with SCAM relegated to private or niche settings – realization sits at ~10-20% for endorsed therapies, 0% for broader vision.
In other words, ignoring the report has saved the NHS many millions. More importantly, it has prevented UK evidence-based healthcare from getting watered down by ineffective therapies.
Could that also have happened without my loud protests (e.g. here and here) at the time?
Nobody can know for sure?
But when I feel a little bit down, I tell myself that I had an important role in saving the UK millions!
Sufficient evidence concerning the impact of traditional Chinese medicine (TCM) on clinical outcomes for breast cancer patients in Taiwan is not available. This study sought to examine the association between TCM integration and post-operative outcomes among women undergoing mastectomies.
Utilizing a large insurance database, the Taiwanese researchers identified a cohort of adult women who underwent breast cancer surgery during the 2010–2019 period. They compared sociodemographic profiles and comorbidities between TCM users and non-users. Multiple logistic regression models were employed to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for both mortality and postoperative complications.
Among 91,298 eligible patients, the one-year pre-operative prevalence of TCM utilization was 40%. Compared to the control group, TCM users demonstrated:
- a significantly lower likelihood of postoperative stroke (OR 0.76, 95% CI 0.62–0.93),
- and a reduced requirement for intensive care (OR 0.74, 95% CI 0.59–0.91).
Moreover, the cumulative exposure of more than 4 TCM consultations within the year preceding surgery was linked to a decreased risk of stroke (OR 0.76, 95% CI 0.61–0.95).
The authors concluded that “our findings indicate that integrating TCM during the year preceding breast cancer surgery is correlated with lower risks of postoperative stroke and a reduced requirement for intensive care. Nevertheless, these observed benefits warrant further verification through prospective and large-scale clinical investigations. Based on these results, we suggest that both Western medical practitioners and public health administrators should be mindful of TCM’s role in the comprehensive care of patients with breast cancer.”
In the paper itelf, the authors “hypothesize that pre-operative TCM integration contributes to the observed reduction in stroke risk and intensive care requirements following mastectomy. These prior insights provide a plausible biological foundation for the favorable outcomes observed in our study”. In other words, they believe that the associations is causal.
I beg to differ!
Much research has demonstrated that people who use so-called alternative medicine (SCAM) in addition to conventional therapies differ from those who don’t. In general, they tend to be more health concious – if not, they would not go to the trouble of using and paying for SCAM. This difference alone suffices to bring about the observed outcomes – even if TCM has no or perhaps a slightly negative overall health effect.
But let’s be generous!
Let’s assume the authors are correct in assuming that the association is causal and that TCM brought about the observed outcomes.
What does that actually mean?
TCM consists of many different modalities. If we just focus on oral medications and assume that there are 1000 different ones [in fact, the number is about 6 times higher], which one do we take to experience the observed outcome? Perhaps all of them?
What I am trying to point out that such research is meaningless; it has zero practical consequences, even if its results were real – which they probably are not.
In the end, it boils down to one main thing: the promotion of unproven (and occasionally dangerous) TCM.
Although currently the COVID-19 pandemic is no longer a public health challenge, the unprecedented utilization and integration of Ayush therapeutics and principles for the COVID-19 response in India represent a critical health systems and policy experiment which needs a systematic evaluation.
A systematic review and meta-analysis was conducted, and the data were extracted till 9th July 2024 using three databases: Scopus, PubMed and DOAJ. A total of seven articles were included for the review, following the PICOS criteria of inclusion and exclusion. Of the 667 articles, seven articles were finally selected, and these articles underwent quality assessment using the AXIS assessment tool. The pooled proportion of the Indian population that utilized the Ayush systems was estimated at a 95% confidence interval, using a random effects model assuming potential heterogeneity. The pooled estimate, publication bias, heterogeneity and sensitivity analysis were graphically represented using a forest, funnel, Galbraith plots and leave-one-out meta-analysis. Additionally, the effects of the small studies were assessed using Egger’s and Begg’s tests. The total sample across the included studies was 789,735. Of the seven articles, six focused on the general population, and five focused on the utilization of the Ayurveda system of medicine. The pooled proportion of the Indian population that utilized the Ayush systems for COVID-19 was 40% (95% CI: 25% − 57%). Based on the policy relevance, risk of exposure, access to guidelines and pattern of utilization two subgroup analyses were carried out. Utilization of multiple systems of Ayush (48%) and utilization among the general population (46%) showed the highest proportion compared to Ayurveda and healthcare workers, respectively. The high heterogeneity (I2 = 99.98%) suggests that the pooled estimate should be interpreted with caution, and the sensitivity analysis found one study had a modest upward influence on the overall estimate.
The authors concluded that this systematic review found a 40% pooled estimate of utilization of Ayush systems from the included studies, suggesting the utilization of these systems to manage mild and asymptomatic conditions and for preventive purposes.
This review reports a 40% pooled utilization rate of Ayush systems for COVID-19 in India, based on just seven studies with a massive sample but extreme heterogeneity (I²=99.98%). Such high heterogeneity undermines the reliability of the pooled estimate, as noted in the study’s own caution and sensitivity analysis showing one study’s outsized influence.
Only seven articles met PICOS criteria from 667 screened, mostly surveys on self-reported use among general populations, without assessing clinical efficacy or outcomes. Quality via AXIS tool is mentioned, but broader Ayush COVID evidence reveals high risk of bias in many trials due to poor randomization, blinding, and variability in interventions. No causal link is drawn between Ayush use and health impacts; the paper merely quantifies popularity amid government promotion.
India faced ~2.4-4.7 million excess deaths in 2020-2021, 7-10x official COVID figures, driven by Delta wave surges, oxygen shortages, and healthcare collapse. Widespread Ayush integration for prevention and mild cases – endorsed by Ministry of Ayush! – did not correlate with better results; high utilization (40-48% in subgroups) coincided with catastrophic mortality levels. Sound evidence for Ayush benefits does not exist. One might therefore speculate that the promotion of Ayush may have diverted resources from proven measures like vaccination and antivirals. In other words, it seems likely that it cost many lives.
