MD, PhD, MAE, FMedSci, FRSB, FRCP, FRCPEd.

bogus claims

Yesterday, someone posted a disparaging comment about Indian research into homeopathy; he claimed that it was unreliable. I agreed, but later I thought ‘HOW ARROGANT OF ME!’. So, I decided to do a little research – actually, it turned out to be a little more than just ‘a little’.

I searched Medline for ‘homeopathy, study, India’. This resulted in 101 hits. Of these 101 articles, 31 contained data published by Indian authors providing evidence at least vaguely related to the effectiveness of homeopathy. I decided to include these in my analysis. Below I quote first the title of each paper followed by (in brackets) the sentence from the 31 abstracts that best describes the direction of the results.

  1. Multimorbidity After Surgical Menopause Treated with Individualized Classical Homeopathy: A Case Report (She was treated with individualized classical homeopathy and followed up for 31 months. She was relieved of the vasomotor symptoms and psychological disturbances of climacteric syndrome, her weight reduced, the ultrasound scan showed absence of lipomatosis/gall bladder disease/hepatic steatosis. Blood tests showed reduction of thyroid stimulating hormone and a balance in the lipid status. Individualized classical homeopathy may have a role in the climacteric syndrome and comorbidities after surgical menopause.)
  2. Therapeutic evaluation of homeopathic treatment for canine oral papillomatosis (The current study proves that the combination of homeopathy drugs aids in fastening the regression of canine oral papilloma and proved to be safe and cost-effective.)
  3. Deep vein thrombosis cured by homeopathy: A case report (The present case report intends to record yet another case of DVT in an old patient totally cured exclusively by the non-invasive method of treatment with micro doses of potentized homeopathic drugs selected on the basis of the totality of symptoms and individualization of the case.)
  4. Diabetic retinopathy screening uptake after health education with or without retinal imaging within the facility in two AYUSH hospitals in Hyderabad, India: A nonrandomized pilot study (AYUSH hospitals could provide a feasible and acceptable location for providing DR screening services.)
  5. Individualised Homeopathic Therapy in ANCA Negative Rapidly Progressive Necrotising Crescentic Glomerulonephritis with Severe Renal Insufficiency – A Case Report (A 60-year-old Indian woman was treated with classical homeopathy for ANCA-negative RPGN, and after one year of treatment, serum creatinine and other parameters indicating renal injury dropped steadily despite the withdrawal of immunosuppressive drugs; renal dialysis, which was conducted twice a week initially, was made rarer and stopped after one year. Classical homeopathy may be considered a potential therapeutic modality in severe pathologies.)
  6. Improvements in long standing cardiac pathologies by individualized homeopathic remedies: A case series (… individualized homeopathic therapy was instituted along with the conventional medicines and the results were encouraging. The changes in the laboratory diagnostic parameters (single-photon emission computed tomography, electrocardiograph, echocardiography and ejection fraction as the case may be) are demonstrated over time. The key result seen in all three cases was the preservation of general well-being while the haemodynamic states also improved.)
  7. Could Homeopathy Become An Alternative Therapy In Dengue Fever? An example Of 10 Case Studies (We present a retrospective case series of 10 Indian patients who were diagnosed with dengue fever and treated exclusively with homeopathic remedies at Bangalore, India. This case series demonstrates with evidence of laboratory reports that even when the platelets dropped considerably there was good result without resorting to any other means.)
  8. Homeopathic Treatment of Vitiligo: A Report of Fourteen Cases (In 14 patients with vitiligo treated with individualized homeopathy, the best results were achieved in the patients who were treated in the early stages of the disease. We believe that homeopathy may be effective in the early stages of vitiligo, but large controlled clinical studies are needed in this area.)
  9. An Exploratory Study of Autonomic Function Investigations in Hemophiliacs on Homoeopathy Medications Using Impedance Plethysmography (Homoeopathic medicines used as an adjunct was associated with decrease in parasympathetic modulations.)
  10. Embryonic Zebrafish Model – A Well-Established Method for Rapidly Assessing the Toxicity of Homeopathic Drugs: – Toxicity Evaluation of Homeopathic Drugs Using Zebrafish Embryo Model (Our findings clearly demonstrate that no toxic effects were observed for these three homeopathic drugs at the potencies and exposure times used in this study. The embryonic zebrafish model is recommended as a well-established method for rapidly assessing the toxicity of homeopathic drugs.)
  11. Treatment of hemorrhoids with individualized homeopathy: An open observational pilot study (Under classical homeopathic treatment, hemorrhoids patients improved considerably in symptoms severity and anoscopic scores. However, being observational trial, our study cannot provide efficacy data. Controlled studies are required.)
  12. Patients’ preference for integrating homeopathy (PPIH) within the standard therapy settings in West Bengal, India: The part 1 (PPIH-1) study (A favorable attitude toward integrating homeopathy into conventional healthcare settings was obtained among the patients attending the homeopathic hospitals in West Bengal, India.)
  13. Patients’ Preference for Integrating Homoeopathy Services within the Secondary Health Care Settings in India: The Part 3 (PPIH-3) Study (A total of 82.40% (95% confidence interval = 79.23, 85.19) of the participants were in favor of integrating homoeopathy services.)
  14. Obstetrics and gynecology outpatient scenario of an Indian homeopathic hospital: A prospective, research-targeted study (The most frequently treated conditions were leucorrhea (20.5%), irregular menses (13.3%), dysmenorrhea (10%), menorrhagia (7.5%), and hypomenorrhea (6.3%). Strongly positive outcomes (+3/+2) were mostly recorded in oligomenorrhea (41.7%), leucorrhea (34.1%), polycystic ovary (33.3%), dysmenorrhea (28%), and irregular menses (22.2%). Individualized prescriptions predominated (95.6%).)
  15. Relative Apoptosis-inducing Potential of Homeopa-thic Condurango 6C and 30C in H460 Lung Cancer Cells In vitro: -Apoptosis-induction by homeopathic Condurango in H460 cells (Condurango 30C had greater apoptotic effect than Condurango 6C as claimed in the homeopathic doctrine.)
  16. Beliefs, attitudes and self-use of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy medicines among senior pharmacy students: An exploratory insight from Andhra Pradesh, India (Pharmacy students held favorable attitude and beliefs about AYUSH use.)
  17. Integrative nanomedicine: treating cancer with nanoscale natural products (Taken together, the nanoparticulate research data and the Banerji Protocols for homeopathic remedies in cancer suggest a way forward for generating advances in cancer treatment with natural product-derived nanomedicines.)
  18. Evidence of an Epigenetic Modification in Cell-cycle Arrest Caused by the Use of Ultra-highly-diluted Gonolobus Condurango Extract (Condurango 30C appeared to trigger key epigenetic events of gene modulation in effectively combating cancer cells, which the placebo was unable to do.)
  19. Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit (Our results indicated a “two-step” mechanism of the induction of apoptosis in tumor cells by calcarea carbonica)
  20. Post-cancer Treatment with Condurango 30C Shows Amelioration of Benzo[a]pyrene-induced Lung Cancer in Rats Through the Molecular Pathway of Caspa- se-3-mediated Apoptosis Induction: -Anti-lung cancer potential of Condurango 30C in rats (The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer through caspase-3-mediated apoptosis induction and EGFR down-regulation.)
  21. The potentized homeopathic drug, Lycopodium clavatum (5C and 15C) has anti-cancer effect on hela cells in vitro (Thus, the highly-diluted, dynamized homeopathic remedies LC-5C and LC-15C demonstrated their capabilities to induce apoptosis in cancer cells, signifying their possible use as supportive medicines in cancer therapy.)
  22. Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy (The result of the present study indicated that the homeopathic drug S jambolanum (mother tincture) has a protective effect on diabetic induced carbohydrate and lipid metabolic disorders in STZ-induced diabetic animal.)
  23. SEM studies on blood cells of Plasmodium berghei infected Balb/c mice treated with artesunate and homeopathic medicine China (The combination of artesunate and China was found to be very effective and did not cause any alteration on the surface of blood cells as observed in SEM.)
  24. Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action (These data indicate that apoptosis is one of the mechanisms of tumor reduction of homeopathic drugs.)
  25. TDZ-induced high frequency shoot regeneration in Cassia sophera Linn. via cotyledonary node explants (Regenerated plantlets were successfully acclimatized and hardened off inside the culture room and then transferred to green house with 100 % survival rate.)
  26. Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro’s Limit Combats Skin Papilloma in Mice (We tested the hypothesis if suitable modulations of signal proteins could be one of the possible pathways of action of a highly diluted homeopathic drug, Secale cornutum 30C (diluted 10(60) times; Sec cor 30). It could successfully combat DMBA + croton oil-induced skin papilloma in mice as evidenced by histological, cytogenetical, immunofluorescence, ELISA and immunoblot findings.)
  27. Can homeopathy bring additional benefits to thalassemic patients on hydroxyurea therapy? Encouraging results of a preliminary study (The homeopathic remedies being inexpensive and without any known side-effects seem to have great potentials in bringing additional benefits to thalassemic patients; particularly in the developing world where blood transfusions suffer from inadequate screening and fall short of the stringent safety standards followed in the developed countries.)
  28. Effect of homeopathic medicines on transplanted tumors in mice (These findings support that homeopathic preparations of Ruta and Hydrastis have significant antitumour activity. The mechanism of action of these medicines is not known at present.)
  29. Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine (These studies demonstrate that homeopathic drugs, at ultra low doses, may be able to decrease tumor induction by carcinogen administration.)
  30. Can homeopathic treatment slow prostate cancer growth? (The findings indicate that selected homeopathic remedies for the present study have no direct cellular anticancer effects but appear to significantly slow the progression of cancer and reduce cancer incidence and mortality in Copenhagen rats injected with MAT-LyLu prostate cancer cells.)
  31. Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice (The results lend further support to our earlier views that microdoses of potentized Arsenicum Album are capable of combating arsenic intoxication in mice, and thus are strong candidates for possible use in human subjects in arsenic contaminated areas under medical supervision.)

So, 31 of 31 yield positive results and conclusions – 100%!

When I suggested that Indian research into homeopathy is suspect, I was merely speculating on the basis of reading such papers for many years. I had not seen a systematic analysis to justify my harsh judgment; in fact, I don’t think that such a review is currently available (which would make this post the first of its kind). I had no idea how true my seemingly disrespectful remark would turn out to be. There is not one paper from India that does not suggest positive findings for homeopathy. I find this truly remarkable!

You can, of course, interpret my findings in two very different ways:

  • Either you assume that homeopathy is hugely effective and works always and for everything under every experimental condition.
  • Or you conclude that Indian research into homeopathy is suspect and far from trustworthy.

If you believe the first option to be true, I fear that you must be as deluded as homeopathic remedies are diluted.

The aim of the paper (published in ‘HOMEOPATHY’) was to perform a systematic review of basic research of homeopathic high dilutions in cancer.

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, we conducted a literature search in the database PubMed for original publications, from 2000 to 2018 and in English, on in vitro and in vivo experimental cancer models testing homeopathic high dilutions.

Twenty-three articles met the inclusion criteria-14 in vitro, eight in vivo, and one in vitro plus in vivo experimental models. Most studies were from India. Research prominently focused on cytotoxic effects involving apoptotic mechanisms. Intrinsic aspects of homeopathy should be considered in experimental designs to emphasize the specificity of such effects.

The authors concluded that fundamental research of homeopathy in cancer is still at an early stage and has mainly been performed by a few groups of investigators. The results point to an interference of well-selected homeopathic medicines with cell cycle and apoptotic mechanisms in cancer cells. However, these findings still need independent reproduction.

I happen to be a co-author of the PRISMA guideline and can assure you that this systematic review is very far from adhering to it. It borders on fraud to state otherwise; at the very minimum, the authors, the editor of ‘HOMEOPATHY‘, as well as the reviewers of this article are guilty of seriously misleading the public. Any reputable journal would have insisted that the abstract of this paper makes the following points very clear so that misunderstandings are avoided:

  1. There is no valid hypothesis to suggest that homeopathic high dilutions affect cancer.
  2. The included studies are mostly of poor or very poor quality.
  3. The results of such pre-clinical in vitro and in vivo experiments have little bearing on the treatment of human cancers.
  4. The fact that independent replications are missing suggests that these studies are irreproducible.
  5. The fact that most studies originate from the same research groups implies that homeopathy is not considered to be a viable avenue by rational thinkers.
  6. In the interest of cancer patients, the idea that homeopathy might be of any use in cancer needs to be discouraged.

In one of my last posts, I stated that research into so-called alternative medicine (SCAM) is fast becoming the laughing stock of serious scientists. This paper is an excellent example of this phenomenon.

 

Unintended consequences are outcomes of a purposeful action that are not intended or foreseen. They exist almost everywhere and often have effects that are the opposite of what was intended.

Just look at our current misery, the pandemic, for instance. Practically all epidemiologists advocated stricter and earlier preventative measures than the ‘anti-lockdown’ brigade in politics and elsewhere wanted and implemented. Had we listened to the epidemiologists, we would almost certainly have had fewer lockdowns and less economic downturn. The unintended consequences of the political decisions to be slow and less than strict with lockdowns are what we can currently observe in many countries:

  • repeated, longer, and less and less effective lockdowns,
  • huge economic damage,
  • more deaths,
  • more long-term illness;
  • financial hardship for many,
  • more psychological problems and frustration.

But I am not here to moan about politicians not listening enough to scientists. I want to vent my anger and concern about much of the research that is currently being published in the realm of so-called alternative medicine (SCAM).

What is happening here – slightly simplified and exaggerated to make my point – is (as often discussed previously) roughly this:

  • more and more enthusiasts of SCAM feel that they should conduct and publish some research;
  • they are largely ignorant of or willfully ignore the accepted standards of science;
  • they have little interest in cause and effect or critical thinking;
  • they aim to promote and not to test SCAM;
  • several SCAM journals have realized that there is good money to be earned from publishing utter rubbish;
  • more and more papers are being published that are flawed to the point of being meaningless;
  • the few relevant SCAM papers with sound science get drowned out and become all but invisible;
  • outsiders glancing at the literature get the impression that SCAM is swamped with rubbish and thus an area that is best avoided;
  • consequently, SCAM research is fast losing all credibility and is becoming the laughing stock of proper scientists;
  • eventually, the notion that ‘ALL SCAM IS RUBBISH’ must filter through into public life;
  • in the end, the pseudo-researchers of SCAM will have provided the nail in SCAM’s coffin.

The INTENDED consequence was to promote SCAM.

The UNINTENDED consequence will be to destroy SCAM.

This self-destructive course of SCAM might be applauded by some skeptics. However, if you believe (as I do) that there are a few good things to be found in SCAM, this development can only be regrettable.

What can be done to avert such a negative outcome?

I wish I knew!

But four productive steps might be the following:

  1. make sure researchers are adequately trained and supervised to do sound science;
  2. motivate funding agencies to stop supporting pseudo-science;
  3. ensure that journal editors and reviewers realize they have the responsibility to avoid publishing nonsense
  4. motivate Medline to de-list a few of the worst SCAM journals.

 

THE TELEGRAPH is not my favourite paper, but occasionally it does publish something worth reading – like, for instance, yesterday when it carried this article:

The head of NHS England warned homeopaths had “crossed the line” after a Sunday Telegraph investigation revealed some were peddling myths that taking duck extract was as effective as the coronavirus vaccines.

Sir Simon Stephens warned people taking their advice from homeopaths were putting themselves at greater risk, and warned they would slow down the nation’s vaccine efforts. His calls were echoed by Professor Stephen Powis, the NHS medical director, who said the findings were the “latest in a long line of disturbing and potentially dangerous online myths”…

Sir Simon told the Sunday Telegraph: “It’s one thing for homeopaths to peddle useless but harmless potions, but they cross a dangerous line when making ridiculous assertions about protecting people from Covid infection. “Anyone who took those seriously would be putting themselves at higher risk of coming to harm from Covid infection.” Prof Powis added: “Spouting claims on social media about Covid cures that are not backed by scientific evidence and accurate public health advice is the latest in a long line of disturbing and potentially dangerous online myths. We urge everyone to ignore misleading claims and get vital protection against Covid when they are invited for their vaccine.” …

Helen Earner, operations director at the Charity Commission, said the findings were being examined as “a matter of urgency”. She added: “Any claims that a charity may be providing misinformation during this time of national emergency is a matter of serious concern to the Commission.” She added that a regulatory compliance case had been opened into the matter and that the commission will be liaising with other agencies as part of the investigation…

These days, I read such articles with mixed feelings. On the one hand, I applaud the fact that UK officials do take note of dangerous quackery and promise to take action. On the other hand, I cannot help feeling a bit frustrated and ask myself: WHY HAS IT TAKEN THEM SO LONG?

I know, for instance, that the Charity Commission has long been dragging its feet to do something about charities that promote overtly dangerous quackery. I have discussed such charities three years ago, and others have done so even before me. As to the UK homeopaths’ (and other practitioners of so-called alternative medicine, SCAM) dangerously bizarre attitude towards vaccinations, I started providing evidence and warning the public as early as 1995.

Perhaps they did not know about it?

Yes, perhaps – I only published these warnings in the

BRITISH JOURNAL OF GENERAL PRACTICE

and in the

BRITISH MEDICAL JOURNAL!

This gets even more frustrating when I consider that the anti-vaccination attitude in SCAM is merely one facet of a much bigger and much more important subject. Starting also in 1995, I published dozens of papers, gave hundreds of lectures on it, and often called it the ‘indirect risks‘ of SCAM. They can be summarised in one single sentence:

EVEN IF A SCAM IS TOTALLY HARMLESS, THE SCAM PRACTITIONER OFTEN ISN’T.

It is therefore tempting to shout:

I TOLD YOU SO!

But that would hardly be helpful. Instead, I let me beg Sir Simon Stephens, Prof Powis, Helen Earner, and anyone else in a position of power to take a minute and consider the wider implications of tolerating SCAM practitioners impose their overtly dangerous health-related views on the unsuspecting public.

Guest post by Ken McLeod

On 31 March 2020, the Chiropractic Board of Australia issued a statement1 to all Australian chiropractors that they:

“should not make advertising claims on preventing or protecting patients and health consumers from contracting COVID-19 or accelerating recovery from COVID-19. To do so involves risk to public safety and may be unlawful advertising. For example, we are seeing some advertising claims that spinal adjustment/manipulation, acupuncture and some products confer or boost immunity or enhance recovery from COVID-19 when there is no acceptable evidence in support.

“Advertisers must be able to provide acceptable evidence of any claims made about treatments that benefit patients/health consumers. We will consider taking action against anyone found to be making false or misleading claims about COVID-19 in advertising. If the advertiser is a registered health practitioner, breaching advertising obligations is also a professional conduct matter which may result in disciplinary action, especially where advertising is clearly false, misleading or exploitative.”

What could be clearer than that?

So what was published by a registered chiropractor on 16 March 2020, two weeks before the Board’s warning, and is still on his website 10 months later? You guessed it, a video on the website of chiropractor Morgan Weber, a video ‘Coronavirus – Balancing the hysteria…’, 2 in which he says:

– the COVID-19 19 pandemic is all ‘hysteria’ and ‘what have we got to worry about’, because ‘Our body, (has) 51 trillion cells’ vs ‘A one single-cell virus,’ (sic.) ‘51 trillion cells that orchestrate our immune system, every function. Yet we seem to have more faith and trust in ‘medicine’ than we do in this amazing body we call home. Crazy, right? Crazy.’

Weber further downplays the crisis by saying ‘Enough of this nonsense about the big bad bug and all the worry about washing your hands.’

Weber, after denigrating evidence-based medicine, recommends instead:

– ‘Keep up with your chiropractic adjustments….’

Weber is a registered chiropractor practicing at Wave Chiropractic, Maroochydore, Queensland, Australia. His AHPRA registration is CHI0001601286. Weber’s webpage home site is at https://www.wavechiropractic.com.au/index.php

WEBER’S VIDEO:

Since 16 March 2020 Weber has posted a video on his website a video ‘Coronavirus – Balancing the hysteria…’. 3

Weber says:

BEGINS TRANSCRIPT

00:00. Hi everyone. Hasn’t it been fascinating lately? The news, the hysteria. Everything has gone almost upside-down. Crazy. I found it so fascinating.

00:12. So today we thought we would have a bit of a chat and sort of balance the scales and the story getting told out there in the mass media. I hope you’ve got your toilet paper stockpiled and sorted ha ha ha ha. It’s hilarious to see people coming and going with huge amounts under their arms as they come out of the grocery store. Crazy isn’t it, crazy times.

00:42. So let’s think about if for a second, and if we bypass all that hysteria and noise and just think a little bit about this. Our body, 51 trillion cells. A one single-cell virus. My gosh. What have we got to worry about? We have this amazing system. 51 trillion cells that orchestrate our immune system, every function. Yet we seem to have more faith and trust in ‘medicine’ than we do in this amazing body we call home. Crazy, right? Crazy.

01:20 ‘The other story, the other sort of facts behind what we do, and I (unintelligible) told a fair few of you of this already, how the immune system works. So, across the road from Waves, we have a really kind of bare patch of grass, just before you go onto the beach. Now if I took a handful of seeds. Now this is an analogy for how our system works, and how amazing our body’s immune system is. If I took a bunch of seeds and dropped them onto the ground, some grass seeds, not all of those seeds would take. There needs to be a hospitable environment, a moist warm sunlit area for those seeds to take, then root and grow into a fully mature grass and perpetuate on and on and on. However that area across the road is barren rocky sandy and yuck. You drop those seeds, most of those are going to blow off and away because that area is a no-go, it’s got a strong resistance, a barrier, a non-hospitable environment.

02:18. Now that is how our immune system works. Now the story I feel that should be out there, is what are you doing to nurture your body to do the best it can be, to have the strongest barrier it can be.

02: 30. Enough of this nonsense about the big bad bug and all the worry about washing your hands. ‘Cause I tell you what, if you are neglecting to nurture your body and the 51 trillion cells to be the best they can be, watch out, that may not be enough, washing your hands.

02:47. So let’s talk about that. How do we orchestrate a healthy system that has a strong immune barrier to anything that’s out there? And really guys, this should be a day-to-day forte (?) for everyone who just wants to be their best.

03:00. So let’s go through it. Boosting your barriers. You need to trust your body. First and foremost, the 51 trillion cells are remarkable. Trust in that.

03: 12. You’ve gotta eat well. Eat well with nutrient-dense, mineral-dense foods. Stay well hydrated. Move. You’ve gotta move well. Exercise your body regularly, moving all parts in all directions. Enjoy healthy sunlight exposure. You’ve gotta think well. Follow your passions and purpose. Think positively. Perhaps switch off the TV.

03:41. Keep up with your chiropractic adjustments. An optimal brain and body communication via the nervous system is vital so ensuring your body is in a surviving state. Do all these things guys. Up the ante of them. Go in harder with your (unintelligible) exercises, your hydration etcetera, and trust in your body. It’s amazing. It’s built with this in-built protective mechanism. Foster it. Help to balance that story out there, and help people to take on a more useful interpretation of this current crisis out there.

04:19. I hope this was of value and you guys enjoy.

END TRANSCRIPT

The regulator has been informed. As the world’s death toll rockets past 2 million, we wait to see if they really meant what they said about disciplinary action.

 

On 10/1/2021 THE GUARDIAN reported about some bizarre anthroposophic treatments in Germany. About a month before, we had discussed the issue here on this blog. The GUARDIAN article prompted the following press release, dated 12/1/2021, by the ‘International Federation of Anthroposophic Medical Associations’ (oddly abbreviated IVAA):

IVAA welcomes the reporting by The Observer, a sister paper of The Guardian, on the care of Covid-19 patients in German anthroposophic hospitals, including critically ill patients in the intensive care ward. The article rightly highlights how these treatments are provided in addition to state-of-the-art conventional treatments, how anthroposophic medicine is fully integrated into the German health care system and how anthroposophy “enjoys a high level of social acceptance and institutional support in German-speaking countries”. The World Health Organization’s Traditional Medicine Strategy has indeed set integration of traditional and complementary medicine into health care systems as one of its strategic goals.

While the article is generally biased against anthroposophic medicine and only quotes two known opponents of anthroposophy, it nevertheless provides welcome reporting on integrative medicine that is highly popular with patients in Europe.

There are many peer-reviewed studies on anthroposophic medicine and anthroposophic medications have been in use for decades, showing an excellent safety profile. The Observer’s critique that patients should provide consent for such treatments does not hold because the treatments are not experimental, are provided in addition to standard care, based on long clinical experience and in hospitals openly publicizing their integrative medicine approach. As the article reports, German insurance companies pay flat-rate payments for hospital treatment of coronavirus patients; the additional anthroposophic treatments are thus financed out of hospital budgets and are cost-neutral for insurance companies.

Unfortunately, and as correctly reported by The Observer, individual supporters of anthroposophic medicine have sided with demonstrations against corona measures; this does in no way reflect the official position of anthroposophic medicine and IVAA member organizations have clearly distanced themselves.

END OF PRESS RELEASE

One does not need to be a champion in critical thinking to realize that this press release deserves a few comments.

  1. The claim that anthroposophic medicine (AM) is ‘fully integrated into the German healthcare system‘ is misleading. In Germany, AM belongs to the special therapeutic measures (‘besondere Therapierichtungen’) which indicates almost the opposite of ‘fully integrated’.
  2. Similarly, AM is not ‘highly accepted’ but belongs to the fringe of so-called alternative medicine (SCAM). There are only very few anthroposophic hospitals in Germany, and most Germans would not even know what AM is.
  3. The press release claims that ‘there are many peer-reviewed studies on anthroposophic medicine‘. The link it provides leads to an AM organization’s list of references. For infections, this list references the following 9 papers:  (1) Martin DD. Fever: Views in Anthroposophic Medicine and their Scientific Validity. Evid Based Complement Alternat Med. 2016;2016(1):13 pages.(2) Soldner G, Stellman HM. Individual Paediatrics: Physical, Emotional and Spiritual Aspects of Diagnosis and Counseling – Anthroposophic-homeopathic Therapy, Fourth edition. 4 edition. CRC Press; 2014. 984 S. (3) Glöckler M, Goebel W. A Guide to Child Health: A Holistic Approach to Raising Healthy Children. Floris Books; 2013. (4) Goebel MW, Michael MK, Glöckler MM. Kindersprechstunde: ein medizinisch-pädagogischer Ratgeber. Verlag Urachhaus; 2016. (5) Szoeke H, Marodi M, Sallay Z, Székely B, Sterner M-G, Hegyi G. Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children: A Prospective Observational Study. Forsch KomplementärmedizinResearch Complement Med. 2016;23(4):231–239. (6) Hamre HJ, Glockmann A, Schwarz R, Riley DS, Baars EW, Kiene H, u. a. Antibiotic use in children with acute respiratory or ear infections: prospective observational comparison of anthroposophic and conventional treatment under routine primary care conditions. Evid Based Complement Alternat Med. 2014;2014(Article ID 243801). (7) Hamre HJ, Fischer M, Heger M, Riley D, Haidvogl M, Baars E, u. a. Anthroposophic vs. conventional therapy of acute respiratory and ear infections. Wien Klin Wochenschr. 2005;117(7–8):256–268. (8) Hamre HJ, Glockmann A, Fischer M, Riley DS, Baars E, Kiene H. Use and Safety of Anthroposophic Medications for Acute Respiratory and Ear Infections: A Prospective Cohort Study. Drug Target Insights. 14. September 2007;2:209–19. (9) Jeschke E, Lüke C, Ostermann T, Tabali M, Huebner J, Matthes H. Verordnungsverhalten anthroposophisch orientierter Ärzte bei akuten Infektionen der oberen Atemwege. Forsch KomplementärmedizinResearch Complement Med. 2007;14(4):207–215.                                                                       These are mostly NOT peer-reviewed papers, and none yields anything close to conclusive findings about the alleged efficacy of AM treatments. The truth is that there is no good evidence to support AM.
  4.  The mention that AM remedies have been used for decades is a fallacy (appeal to tradition).
  5.  Yes, AM remedies are safe – mainly because they, like homeopathic remedies, usually contain no active ingredients.
  6.  Patients should provide consent for such treatments to ALL treatments, experimental or not.
  7. Clinicians practicing AM have long been known to hold an anti-vax attitude which has also caused problems in the past.

My conclusion: this press release was written in true anthroposophic style and spirit: ill-informed, in disregard of medical ethics, based on wishful thinking and aimed at misleading the public.

The aim of this investigation was to evaluate the marketing practices, beliefs and health claims regarding the use of colloidal silver in Finland. Contents of three company websites selling colloidal silver were reviewed, and the claims used in the marketing of colloidal silver were compared to the scientific information about silver. In Facebook posts and discussion about colloidal silver were analyzed.

In Finland, the marketing of colloidal silver products on websites selling the products did not follow the regulations of authorities; several scientifically unfounded claims about the efficacy and medical use of colloidal silver were found. After the Finnish Broadcasting Company (Yle) documentary and an intervention by authorities, contents of the websites were changed, but still questionable information and misleading claims could be found. In the analyzed Facebook groups attitudes towards medical use of colloidal silver were uncritically positive, internal use was highly promoted and the restrictions of use were considered unjustified.

The authors concluded that the use of quackery products such as colloidal silver can be dangerous, and their use and marketing should be controlled and restricted.

The authors stress that silver nanoparticles (AgNPs) are potentially toxic due to their small size and Ag+-release capabilities, and the use of colloidal silver products containing AgNPs can cause a wide variety of adverse effects such as argyria.

WebMD cautions that despite promoters’ claims, silver has no known function in the body and is not an essential mineral supplement. Colloidal silver products were once available as over-the-counter drug products. In 1999 the U.S. Food and Drug Administration (FDA) ruled that these colloidal silver products were not considered safe or effective. Colloidal silver products marketed for medical purposes or promoted for unproven uses are now considered “misbranded” under the law without appropriate FDA approval as a new drug. There are currently no FDA-approved over-the-counter or prescription drugs containing silver that are taken by mouth. However, there are still colloidal silver products being sold as homeopathic remedies and dietary supplements.

On this blog, we have discussed that colloidal silver is nevertheless marketed aggressively by crooks (see here and here). The message that emerges from all this seems clear: do not fall for the plethora of false claims made by irresponsible entrepreneurs who want your money and risk your health. Keep your money and health by staying away from colloidal silver and similar SCAMs.

The state of acupuncture research has long puzzled me. The first thing that would strike who looks at it is its phenomenal increase:

  • Until around the year 2000, Medline listed about 200 papers per year on the subject.
  • From 2005, there was a steep, near-linear increase.
  • It peaked in 2020 when we had a record-breaking 20515 acupuncture papers currently listed in Medline.

Which this amount of research, one would expect to get somewhere. In particular, one would hope to slowly know whether acupuncture works and, if so, for which conditions. But this is not the case.

On the contrary, the acupuncture literature is a complete mess in which it gets more and more difficult to differentiate the reliable from the unreliable, the useful from the redundant, and the truth from the lies. Because of this profound confusion, acupuncture fans are able to claim that their pet-therapy is demonstrably effective for a wide range of conditions, while skeptics insist it is a theatrical placebo. The consumer might listen in bewilderment.

Yesterday (18/1/2021), I had a quick (actually, it was not that quick after all) look into what Medline currently lists in terms of new acupuncture research published in 2021 and found a few other things that are remarkable:

  1. There were already 100 papers dated 2021 (today, there were even 118); that corresponds to about 5 new articles per day and makes acupuncture one of the most research-active areas of so-called alternative medicine (SCAM).
  2. Of these 100 papers, only 7 were clinical trials (CTs). In my view, clinical trials would be more important than any other type of research on acupuncture. To see that they amount to just 7% of the total is therefore disappointing.
  3. Twelve papers were systematic reviews (SRs). It is odd, I find, to see almost twice the amount of SRs than CTs.
  4. Eighteen papers referred to protocols of studies of SRs. In particular protocols of SRs are useless in my view. It seems to me that the explanation for this plethora of published protocols might be the fact that Chinese researchers are extremely keen to get papers into Western journals; it is an essential boost to their careers.
  5. Seven papers were surveys. This multitude of survey research is typical for all types of SCAM.
  6. Twenty-four articles were on basic research. I find basic research into an ancient therapy of questionable clinical use more than a bit strange.
  7. The rest of the articles were other types of publications and a few were misclassified.
  8. The vast majority (n = 81) of the 100 papers were authored exclusively by Chinese researchers (and a few Korean). In view of the fact that it has been shown repeatedly that practically all acupuncture studies from China report positive results and that data fabrication seems rife in China, this dominance of China could be concerning indeed.

Yes, I find all this quite concerning. I feel that we are swamped with plenty of pseudo-research on acupuncture that is of doubtful (in many cases very doubtful) reliability. Eventually, this will create an overall picture for the public that is misleading to the extreme (to check the validity of the original research is a monster task and way beyond what even an interested layperson can do).

And what might be the solution? I am not sure I have one. But for starters, I think, that journal editors should get a lot more discerning when it comes to article submissions from (Chinese) acupuncture researchers. My advice to them and everyone else:

if it sounds too good to be true, it probably is!

Turmeric is certainly a plant with fascinating properties; we have therefore discussed it before. Reseach into turmeric continues to be active, and I will continue to report about new studies.

This study was aimed at estimating the effect of turmeric supplementation on quality of life (QoL) and haematological parameters in breast cancer patients who were on Paclitaxel chemotherapy. In this case series with 60 participants, QoL was assessed using a standard questionnaire and haematological parameters were recorded from the patients’ hospital records.

Turmeric supplementation for 21 days resulted in clinically relevant and statistically significant improvement in global health status, symptom scores (fatigue, nausea, vomiting, pain, appetite loss, insomnia), and haematological parameters.

The authors concluded that turmeric supplementation improved QoL, brought about symptom palliation and increased hematological parameters in breast cancer patients.

Really?

The way the conclusions are phrased, they clearly imply that turmeric caused the observed outcomes. How certain can we be that this is true?

On a scale of 0 -10, I would say 0.

Why?

Because there are important other determinants of the outcomes:

  • placebo,
  • concommittant treatments,
  • natural history,
  • etc., etc.

Why does this matter?

  • Because such unwarranted conclusions mislead patients, healthcare professionals and carers.
  • Because such bad science gives a bad name to clinical research.
  • Because this type of nonsense might deter meaningful research into a promising subject.
  • Because no ‘scientific’ journal should be permitted to publish such nonsense.
  • Because it is unethical of ‘scientists’ to make false claims.

But maybe the Indian authors are just a few well-meaning and naive practitioners who merely were doing their unexperienced best? Sadly not! The authors of this paper give the following affiliations:

  • Clinical Pharmacology, Pfizer Healthcare Private Limited, Chennai, Tamil Nadu, India.
  • Department of Radiation Oncology, Faculty of Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.
  • Process Development, HCL Technologies, Chennai, Tamil Nadu, India.
  • Department of Pharmacognosy, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.

Yes, they really should know better!

So-called alternative medicine (SCAM) is, as we all know, an umbrella term. Under this umbrella, we find hundreds of different modalities that have little in common with each other. Here I often focus on:

  • homeopathy,
  • chiropractic,
  • acupuncture,
  • herbal medicine.

There are uncounted others, and in my recent book, I published critical evaluations 150 of them. But for the moment, let’s keep to the 4 SCAMs listed above.

What strikes me regularly is that many SCAM enthusiasts do seem to appreciate my critical assessments of SCAM; for instance:

  • When I point out that the assumptions of homeopathy fly in the face of science, most SCAM enthusiasts agree.
  • When I point out that chiropractic spinal manipulations might not be safe, most SCAM enthusiasts agree.
  • When I point out that acupuncture is not a panacea, most SCAM enthusiasts agree.
  • When I point out that herbal remedies can interact with prescribed drugs, most SCAM enthusiasts agree.

Most but not all!

  • Those who find my criticism of homeopathy unfair are the homeopaths and their proponents.
  • Those who find my criticism of chiropractic unfair are the chiropractors and their proponents.
  • Those who find my criticism of acupuncture unfair are the acupuncturists and their proponents.
  • Those who find my criticism of herbal medicine unfair are the herbalists and their proponents.

Hardly ever does a herbalist defend homeopathy’s weird assumptions; rarely does an acupuncturist tell me that I am too harsh with the chiropractors; never have I heard a chiropractor complain that my criticism of acupuncture is unjustified.

Entirely obvious?

Perhaps!

But I find it nevertheless curious, because my critical stance is always the same. I do not change it for this or that form of SCAM (I would also not change it for conventional medicine, but I leave it to those who have more specific expertise to do the criticising). I have no axe to grind against any particular SCAM. All I do is point out flaws in their logic, limitations in their studies, gaps in the evidence. All I do is provide my honest interpretation of the evidence.

It really seems to me that everyone appreciates my honesty, until I start being honest with them.

And this is why I find it curious. Homeopaths, chiropractors, acupuncturists, herbalists and all the other types of SCAM practitioners like to be seen on the side of science, evidence, critical thinking and progress. This, I suppose, is good for the (self) image; it might even help the delusion that they are all evidence-based. But as soon as someone applies science, evidence, critical thinking and progress to their very own little niche within SCAM, they stop liking it and start aggressing the critic.

I suppose this is entirely obvious as well?

Perhaps!

But it also exposes the double standard that is so deeply ingrained in SCAM.

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