MD, PhD, MAE, FMedSci, FRCP, FRCPEd.

Critics of so-called alternative medicine (SCAM) often point out that much of it lacks plausibility. Proponents of SCAM tend to think that this is an irrelevance. So, what is plausibility, and why does it matter?

Think of scientific plausibility as a reality check. Before scientists spend time and money testing a new idea, they ask a basic question: Does it actually line up with what we already know about how the universe works? While an idea being plausible doesn’t automatically make it true, it acts as a crucial filter. It helps us separate ideas that are worth investigating from those that break the fundamental laws of logic, physics, chemistry, biology, etc.

This is exactly where many SCAMs fall apart. Their claims often contradict basic science before a study even begins. Take homeopathy, for example. It relies on the idea that a substance can cure an illness, even if it is diluted over and over again, often to the point where not a single molecule of the original ingredient is left. This directly defies molecular theory and the well-established “dose-response relationship,” which simply states that the amount of a substance matters. Similarly, practices like “energy healing” postulate mysterious vital energies that cannot be seen, felt, or measured by any instrument known to modern science.

This matters because it changes how we look at “proof.” In science, if an idea is highly unlikely from the start, a single positive study usually isn’t a breakthrough. Instead, it’s much more likely to be a fluke, a statistical error, the result of a flawed experiment or even fraud.

Instead of trying to fix these scientific contradictions, proponents of SCAM often change the subject or move the goalpost. They might, for instance, that claim the scientific method is closed-minded or simply ignore negative results. But you cannot bypass the rules of reality. If a treatment claims to do something that contradicts everything we know about nature, it requires extraordinary proof to be taken seriously.

I do understand why SCAM enthusiasts try to ignore the issue of plausibility. But ignoring it runs several risks. For instance, it risks doing research that is entirely wasteful. More importantly perhaps, it risks paying undue attention to false positive results which, in turn, can seriously harm vulnerable patients – just think of a cancer patient who has fallen victim to the claims of homeopaths – backed by multiple, implausible and fase-positive results – suggesting that homeopathy can cure cancer.

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