MD, PhD, MAE, FMedSci, FRSB, FRCP, FRCPEd.

This study tested the efficacy and safety of individualized homeopathic medicines (IHMs) in treating hemorrhoids compared with placebo. The double-blind, randomized (1:1), two parallel arms, placebo-controlled trial was conducted at the surgery outpatient department of the State National Homoeopathic Medical College and Hospital, Lucknow, Uttar Pradesh, India.

Patients were 140 women and men, aged between 18 and 65 years, with a diagnosis of primary hemorrhoids grades I-III for at least 3 months. Excluded were the patients with grade IV hemorrhoids, anal fissure, and fistula, hypertrophic anal papillae, inflammatory bowel disease, coagulation disorders, rectal malignancies, obstructed portal circulation, patients requiring immediate surgical intervention, and vulnerable samples.

Patients were randomized to Group 1 (n = 70; IHMs plus concomitant care; verum) and Group 2 (n = 70; placebos plus concomitant care; control). Primary-the anorectal symptom severity and quality-of-life (ARSSQoL) questionnaire, and secondary-the EuroQol 5-dimensions 5-levels (EQ-5D-5L) questionnaire and EQ visual analogue scale (VAS); all of them were measured at baseline, and every month, up to 3 months.

Out of the 140 randomized patients, 122 were protocol compliant. Intention-to-treat sample (n = 140) was analyzed. The level of significance was set at p < 0.05 two tailed. Statistically significant between-group differences were elicited in the ARSSQoL total (Mann-Whitney U [MWU]: 1227.0, p < 0.001) and EQ-5D-5L VAS (MWU: 1228.0, p = 0.001) favoring homeopathy against placebos. Sulfur was the most frequently prescribed medicine. No harm or serious adverse events were reported from either of the groups.

The authors concluded that IHMs demonstrated superior results over placebo in the short-term treatment of hemorrhoids of grades I-III. The findings are promising, but need to be substantiated by further phase 3 trials.

Yes, I know: it is not easy to keep a straight face when reading such a paper. And the task is not made easier when considering the affiliations of its authors:

  • 1East Bishnupur State Homoeopathic Dispensary, Chandi Daulatabad Block Primary Health Centre, Under Department of Health & Family Welfare, Government of West Bengal, India, South 24 Parganas, India.
  • 2Department of Organon of Medicine and Homoeopathic Philosophy, State National Homoeopathic Medical College and Hospital, Lucknow, India.
  • 3Department of AYUSH, Government of Uttar Pradesh, Lucknow, India.
  • 4State National Homoeopathic Medical College and Hospital, Lucknow, India.
  • 5Department of Materia Medica, State National Homoeopathic Medical College and Hospital, Lucknow, India.
  • 6Department of Pathology & Microbiology, D. N. De Homoeopathic Medical College & Hospital, Government of West Bengal, Kolkata, India.
  • 7Department of Pathology & Microbiology, Mahesh Bhattacharyya Homoeopathic Medical College & Hospital, Government of West Bengal, Howrah, India.
  • 8Department of Repertory, D. N. De Homoeopathic Medical College and Hospital, Kolkata, India.

Let’s nevertheless ask three serious questions:

  1. According to classical homeopathy, for a cure, one needs a remedy that, when given to a healthy volunteer, causes the symptom one wants to treat. So, does sulfur etc.cause the symptoms of hemorrhoids?
  2. According to classical homeopathy, the remedy is supposed to cure the condition, not alleviate the symptoms. Is that what the results show?
  3. Is it plausible that homeopathy can have any effects on hemorrhoids?

I am confident that the answers are: no, no and no.

And this leads me to ask my final question: do we believe these findings?

I let you answer this one!

40 Responses to Homeopathy for hemorrhoids? (Or is perhaps homeopathy a pain in the backside?)

  • Thx for your placebo response with no critical analysis of any fault on this randomized double blind placebo controlled trial.

    And yes, all of those drugs you listed are known to cause the symptoms that they are found to cure.

    Please provide a real critique not a completely uneducated one.

    • And yes, all of those drugs you listed are known to cause the symptoms that they are found to cure.

      Edzard only mentioned sulfur, Dana.

      Any evidence to support your assertion?

      • Hey Lenny…what do YOU think about this study…published in a high impact conventional journal:

        Abstract:

        The subject of ultrahigh dilutions has been under continuous debate over the years, mainly because the possibilities to analyze such diluted solutions are limited. In this context, transmission electron microscopy (TEM) investigations were conducted to evaluate the morphological characteristics of ethanol- and water-based highly diluted solutions of gold; three levels of potentization (6C, 30C, and 200C) were examined for each type of solution. Moreover, Raman spectroscopy and deep learning (DL) algorithms were employed for the analysis of the three potentization levels of purified water, unpurified water, and purified water-based gold solutions. Three batches were assessed for each considered category, and the ability to discriminate between all investigated classes, between the potencies within each group or between the classes within the same level of potentization were presented and discussed in correlation with the TEM findings. Distinct forms of organization were revealed by TEM for the three levels of potentization, while the gated recurrent unit (GRU) model showed great accuracy (88 %) for discriminating all classes, over 90 % accuracy for distinguishing the samples within each group and over 95 % accuracy for classification within the same level of potentization if unpretreated Raman spectra were used. Thus, this suite of methods (TEM-EDX and Raman spectroscopy in combination with DL) can be successfully used for the characterization and differentiation of highly diluted solutions resulting from potentization treatment. Furthermore, considering the results obtained from the discrimination study involving all 11 classes and a data augmentation approach, the spectral segmentation method can be seen as a valuable strategy for increasing the model prediction accuracy.

        Results:
        ” In this study, we show that it is possible to use a suite of methods (transmission electron microscopy/TEM-EDX and Raman spectroscopy in combination with Deep Learning/DL) for successful characterization and differentiation of highly diluted solutions that are obtained after the potentization treatment. TEM-EDX can be used to assess the composition and morphology of any colloidal solution. We show here that this technique is efficient even for highly diluted solutions, allowing us to obtain valuable information related to each level of potentization and, in this way, to discriminate them by creating an image that could be associated with each potentization level.”

        Conclusions:
        “Overall, by analyzing the results obtained from TEM-EDX and the methodology based on Raman spectroscopy and DL algorithms, we can argue that these methods can be successfully used for the characterization of ultrahigh dilutions. This suite of techniques revealed a modality that could be the basis for discriminating different remedies in accordance with the nature of the initial substances used to prepare the remedies or could allow the differentiation of samples based on their level of potentization. This approach allows the analysis of the highly diluted solutions on a far larger scale than was achievable in the past.”

        Grosan Camelia, Isik Sahin, Porav Alin, Dag Ilknur, Ay Kursad, Vithoulkas George. (2024). Ultra-high dilutions analysis: Exploring the effects of potentization by electron microscopy, Raman spectroscopy and deep learning. Journal of Molecular Liquids. 124537. 10.1016/j.molliq.2024.124537. https://www.sciencedirect.com/science/article/pii/S0167732224005932?via%3Dihub

        The Journal of Molecular L

        • Your reply, Mr Ullman, has nothing whatsoever to do with your initial comment and the question that you were asked about it.

          You wrote on Wednesday 26 June 2024 at 09:26:

          And yes, all of those drugs you listed are known to cause the symptoms that they are found to cure.

          Other than sulfur, what are all those drugs listed in Edzard’s article?

        • Hey Lenny…what do YOU think about this study…published in a high impact conventional journal:

          High impact? The Journal Of Molecular Liquids has an impact factor of 6.0 Dana you pathetic, ignorant yammering goon. It is a predatory pay-to-publish piece of shit which will print any old shit. Like the paper you’re waving about in triumph which is yet another piece of specious garbage from a bunch of blinkered loons which attempts to posit a mechanism of action for something that doesn’t work.

          Now how about answering the question?

          • I already answered your question about sulphur. The fact that you’re ignorant of toxicology and homeopathic materia medica is showing.

            And an impact factor of 6 is significant and you’re showing more ignorance and bias. Pathetic.

            Now, please provide a real critique of the two articles rather than your ad homs.

          • I already answered your question about sulphur.

            Where?

            Lying again, Dana. This imagination of yours is becoming a bit of a problem.

            Now, please provide a real critique of the two articles rather than your ad homs.

            You still don’t know what an ad hom is, do you?

            And the critiques stand. Claiming that a therapy that has never reproducibly proven any effectiveness shows effectiveness means the first paper is garbage. Claiming a mechanism of action for said ineffective therapy means the second is.

            Do you think anyone apart from yourself will pay any attention to the papers, Dana?

            They, like you, will be ignored.

          • Mr Ullman wrote: “I already answered your question about sulphur.”

            The only occurrence of the word sulphur is in that very sentence of yours; and you have not mentioned the word that was used in the article and in the question put to you, which is “sulfur”.

            Now, other than sulfur, what are all those drugs listed in Edzard’s article?

          • @DUllman

            How many more smokescreens are you going to fire to cover your pathetic retreat after being discovered lying?

          • Not the first time that Mr Ullman has lied in this blog about answering something he hasn’t. Still waiting Mr Ullman. Eighty-first time of asking….

          • The paradigmatic reviews from Ernst:

            “A systematic review of systematic reviews of homeopathy” BJCP.
            Impact Factor: 3.4

            “Homeopathy: what does the “best” evidence tell us?” Medical Journal Australia
            Impact Factor: 11.4

            VS

            “Is evidence for homoeopathy reproducible?”
            Impact Factor: 98.4

            Then, what is your point Lenny?

        • Hey Dana, how stupid do you think the readers are that you keep conjuring up questionable studies from the low level Journal Of Molecular Liquids as proof of your ridiculous theses, even though it has been explained to you often enough that the studies are useless?

          Declaration of competing interest
          Camelia Berghian-Grosan and George Vithoulkas report article publishing charges was provided by International Academy of Classical Homeopathy. George Vithoulkas reports a relationship with International Academy of Classical Homeopathy that includes: board membership. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

          Acknowledgements
          The authors would like to thank the International Academy for Classical Homeopathy (I.A.C.H.) – Alonissos (Greece) for the support provided for this research and Dr. Drosos Kourounis for his suggestions and corrections that considerably improved the quality of this manuscript. Special thanks are extended to Korres Pharmacy and Mr. George Korres (Greece, http://www.korres.com) for the preparation of the homeopathic solutions.

          • You are speaking and writing out of your back-side, my friend.

            The JOURNAL OF MOLECULAR LIQUIDS has a 6.0 impact factor…that is NOT insignificant, especially for a technical journal…but I expect back-side comments from you.

            As yet, neither you or any of your fellow culltists here have provided even a whisper of a real analysis…once again, I’m not surprised by the lack of intellectual or scientific rigor.

            Peace out.

        • Mr Ullman’s quote includes:

          “This approach allows the analysis of the highly diluted solutions on a far larger scale than was achievable in the past.”

          That is abject BS. Why? The substance under test was GOLD, which is one of the most insoluble materials in either of the test solvents: water and ethanol.

          Where are the authors’ test results for the commonly used, soluble, homeopathic ‘remedy’ Natrium muriaticum; or as George Vithoulkas delights in misspelling it, Natrum muriaticum?

          We’ve been over this countless times.

        • @Dana Ullman
          So let’s get this straight. Those water-shaking clowns tried diluting metallic gold in water. And even when their dilution should have reached 10^400 (less than 1 particle of gold in the volume of some 10^350 universes), those clowns claim that they still detected gold.

          Well, that seems straightforward: they simply messed up their dilution process.

          NEXT

    • Thx for your placebo response, Mr Ullman, with no critical analysis of this randomized double blind placebo controlled trial [sic].

      Please provide a real critique, not a completely uneducated one.

    • Thanks, Dana, for answering the question posed in the title of my post.

    • Mr Ullman,
      We have asked you literally dozens or even hundreds of times to name one or more homeopathic preparations 12C+ exhibiting significant and consistent effects that can be reliably replicated.

      So far, you (or other homeopaths) have not identified even one such homeopathic preparation. NOT ONE. In fact, in all 228 years of homeopathy’s existence, not a single such experiment and/or homeopathic preparation has ever been identified. Any and all effects of homeopathic preparations tend to vanish almost instantly under proper scientific scrutiny.

      So please enlighten us what use an elaborate ‘critical analysis’ is when you can’t identify even one homeopathic preparation that has any consistent, repeatable effect?

    • Please provide a real critique not a completely uneducated one.

      Says the quack, who constantly presents himself as uneducated in his answers and is completely incapable of criticism.

  • This ‘study’ is an example of proctophasia if ever I saw one. But whatever these water-shaking clowns manage to pull from their rear end, it sure as hell ain’t haemorrhoids.

    According to classical homeopathy, for a cure, one needs a remedy that, when given to a healthy volunteer, causes the symptom one wants to treat. So, does sulfur etc.cause the symptoms of hemorrhoids?

    I simply looked for the phrase “What causes haemorrhoids”, and the answers are pretty consistent, along the following lines:
    – Straining during bowel movements.
    – Sitting for long periods of time, especially on the toilet.
    – Having chronic diarrhea or constipation.
    – Being obese.
    – Being pregnant.
    – Having anal intercourse.
    – Eating a low-fiber diet.
    – Regularly lifting heavy items.
    So now the question becomes how those water-shaking clowns manage to turn those causes into a homeopathic preparation … No, I don’t want to know.

    I still have this secret hope that the Indian government will one day realize that their ill-informed support and recognition of homeopathy makes them the laughing stock of the scientific world. Then again, this day will most likely be a long way off yet.

  • “The findings are promising, but need to be substantiated by further phase 3 trials.”

    So the findings are suppositorial rather than definitive.

  • An amusing anecdote. We were on holiday in Kerala and visited a Indian traditional doctor. He proudly showed me his garden of medicinal plants each with a label for condition to be treated. One plant was for “haemorrhoids” and another one was for “piles”. As a sufferer of both conditions I shook hands with my new friend on leaving.

  • Phase III trials! I thought homeopathic clinical reserach consisted of mostly small, poor pilot or phase I studies that get easily deconstructed and then seldom get to stage II phase.
    It looks like these studies in India and South America are going to keep Edzard busy with larger more advanced homeopathy trials taking place. Lots more articles are bubbling under and are likely to be published in 2024/25 for Edzard to deconstruct.
    This all must be quite a headache for Edzard or would it be best to describe this developing situation as a pain in the arse?

  • A personal comment from my side.

    I have no scientific findings I can add to the discussion. However, I have an anecdotal story to tell:
    I had hemorrhoids for a couple of years, and I treated them in a very classic way. A doctor used rubber bands to pinch of cherry-sized (the doctor told me) tissue in order to reduce hemorrhoids. I did it several times until another doctor told me that it was no good idea to set wounds this way in my gut.

    Then I ordered in some kind of self-experiment a hemorrhoid nosodes with very high potency (I think it was C1000). nosodes are tissue material from effected body parts or pathogens. In my case, it was tissue from a hemorrhoid.

    I took this remedy once and after that treatment all my problems regarding hemorrhoids were solved – and it was about 15 years ago I took it.

    I have to add that these nosodes are no longer available as it was forbidden to produce and sell them. I was glad I got one of the last.

    I can’t argue that this nosodes cured my hemorrhoids, as the mode of action is completely unknown. However, I can state that my problems no longer occurred after I took this nosode.

    There are a few issues I regularly cure using homeopathic remedies and where my experience gave me a foundation for good trust and expectation of healing. I would not use homeopathic approaches for everything. However, for some issues they are first choice for me and other issues are for classic medical approaches I maybe would accompany by homeopathic treatment. This is my very pragmatic approach.

    According to my experience and also the paper you cited, hemorrhoids seem to be an issue where homeopathic remedies have some potential to make a difference.

    • “Nosodes” are utter nonsense.

      Homeopathy does not work at all.

      Your “example” not only is worthless, but just one more try to cheat the public with a “but it worked for me” story. It stinks like the so many success stories told by bought shills.

    • Homeopathic nosode for pain in the backside… Hmmm? Wonder what they put in the flask to completely shake-wash out of it again? Maybe the contents of a thrombosed pile? Or some swabings from the anal orifice of a sufferer??

      Your little story, Holger, might well be true, but not for the reasons Mr D.Ullman and other disciples of Hahnemann would like to be true.
      It reminds me of a clinical experience of mine that can explain such seeming miracles.

      I had a patient once, a little old lady who had a fairly constant, hemorrhoid like pain in her anal orifice. I found nothing. Even rectovaginal examination awake and under anaesthesia, MRI of pelvis and spinal cord and electrophysiological studies did not produce any explanation. We discussed the abscence of any explanation and its meaning. Once again ( I had done so at the initial evaluation) I asked about her social setting and possible psych-social factors, social or financial worries etc. She had not reported any such factors initially but at this last, sombre, end-of-the diagnostic road she came to think of one thing. She had lost her husband some years back and not yet made arrangements to settle their estate or whatever it is called in English when one gets a lawyer to make arrangements for the children to inherit and all that. She was always kicking this uncomfortable ball down the road and it did cause her some constant concern. I suggested to her that there might at least be some hope for palliation if she were free from the burden of such unfinished business. I gave her a new appointment in a monts time and said we could at leasts have another chat if nothing else.
      When she entered the surgery a month later I immediately noted a dramatic change in her demeanor. She was virtually glowing and glad and said: “Doctor, you were right! I called a lawyer and we got this rather depressing thing sat in order. The next day my pain was gone and I haven’t felt anything since”.
      I seem to recall she hugged me .
      This little episode taught me more than any textbook in medicine, surgery or psychology and I think I have made many a student, intern and resident a better doctor by telling it to them.
      It is well known how “internalised” worries and unresolved psychological burden may cause or aggravate many kinds of bodily symptoms, often increased resting tone in muscles or other forms of chronic pain states. Pelvic or anal pain and indeed many chronic pain syndromes sometimes have a large causative psychological component of this kind. Taking all possible factors into account when making a diagnoses and helping people resolve their health problems is called “a holistic approach”. This is a clinical term that SCAM-artists have erroneously appropriated but cannot actually fulfil as they lack the component of useful, effective modern medicine. All good medical doctors (the real kind) practice holistically, looking at the patient as a whole, not as a well you throw your favourite SCAM into in return for monetary remnueration and a false sense of virtuosity.

      Ah, well… enough with these idle musings… back to work!

      • Björn Geir on Wednesday 26 June 2024 at 14:45

        “I have made many a student, intern and resident a better doctor by telling it to them.
        It is well known how “internalised” worries and unresolved psychological burden may cause or aggravate many kinds of bodily symptoms, often increased resting tone in muscles or other forms of chronic pain states.”

        Very impressive. You could make a decent homeopath. A good homeopath would have reached this conclusion a lot earlier. But when you solved this case did you also make sure that this patient in “similar emotional stress situation” would not come up with another pain?

        http://www.homeoint.org/books/boericmm/i/ign.htm

        Mentally, the emotional element is uppermost, and co-ordination of function is interfered with.
        The superficial and erratic character of its symptoms is most characteristic. Effects of grief and worry.

        Rectum.–Itching and stitching up the rectum. Prolapse. Stools pass with difficulty; painful constriction of anus after stool. Stitches in hæmorrhoids during cough. Diarrhœa from fright. Stitches from anus deep into rectum. Hæmorrhage and pain; worse when stool is loose. Pressure as of a sharp instrument from within outward.

    • The vast majority of people who try homeopathy are initially skeptical about it…and it is extremely (!) common for people to be utterly amazed at the results…with themselves, with their infants and children, and with their pets too.

      Modern medicine is moving towards nanomedicines…and homeopathy is the original nanomedicine.

      These skeptics here are dinosaurs…and typically, dinosaurs yell and scream the loudest before their fall.

      TIMBER!

      • “The vast majority of people who try homeopathy are initially skeptical about it…and it is extremely (!) common for people to be utterly amazed at the results…with themselves, with their infants and children, and with their pets too.”

        Furthermore, Mr Ullman, I have never encountered an infant or a pet that was initially skeptical about homeopathy, which serves as a valuable lesson to adult humans !

      • Modern medicine is moving towards nanomedicines…and homeopathy is the original nanomedicine

        You keep saying this, Dana. It remains bullshit.

        How come none of the nanomedicine journals contain any articles about homeopathy?

        These skeptics here are dinosaurs…and typically, dinosaurs yell and scream the loudest before their fall.

        What are you going on about you stupid man? Homeopathy has had 200 years to prove itself, has consistently failed to do so and has been laughed at by scientists since Mad Sam first pulled the idea out of his arse. You view yourself as an evangelistic visionary. Everyone else views you as a bit of a tit.

      • Modern medicine is moving towards nanomedicines…and homeopathy is the original nanomedicine.

        Utter bullshit.

        These skeptics here are dinosaurs…and typically, dinosaurs yell and scream the loudest before their fall.

        Dinosaurs lived and thrived successfully on earth for about 170 million years. Skepticism was developed by the ancient Greeks around 2500 years ago. Homeopathy was only invented around 200 years ago.

        Your comparison with dinosaurs was intended as an insult, but is actually a praise. On the other hand, it shows what a small-minded, ignorant braggart you really are,

      • @Dana Ullman

        These skeptics here are dinosaurs …

        Interesting how you try to portray people here as the last remnants of an old guard who foolishly refuse to accept the huge mountains of evidence for the efficacy of modern homeopathy …

        … while in reality, those sceptics here simply represent the absolutely overwhelming scientific consensus that the real fools are homeopaths, still clinging to a silly system of belief made up over 200 years ago. Then again, homeopaths are known for completely turning reality upside down in attempts to make themselves as well as homeopathy look far more significant than they really are.

        When e.g. you look on PubMed for ‘Randomized Controlled Trial’ for homeopathy, you will on average find only about a dozen hits per year(*) – with overwhelmingly inconclusive and negative outcomes.
        But just so that you can’t say that I assumed a negative bias, I took the absolute peak year 2022 with (WHOA!) no less than 24 RCTs.

        And what do you know? ALMOST ALL OUTCOMES WERE EITHER NEGATIVE, INCONCLUSIVE, OR ‘WARRANTED FURTHER RESEARCH’. And even in the 2 or 3 studies with a positive outcome, the effect size was tiny, still apart from other weaknesses and shortcomings.

        So anyone still claiming that homeopathy is a proven effective way to treat ailments(**) can only be described as a pathetic fool. And talking of which:

        homeopathy is the original nanomedicine

        Once again, science (and reality) begs to differ. PubMed only turns up a dozen or so hits when looking for nanomedicine + homeopathy, none of which peer-reviewed, and all highly speculative heaps of nonsense.
        Nanomedicine by itself turns op a whopping 50,000 hits. Which once again tells me that homeopaths have merely hijacked this term to ‘explain’ the purported effects of homeopathy – effects that no-one has been able to reliably reproduce.

        *: For a whole ‘system of medicine’, mind you. For comparison, just the speciality of endocrinology alone turns up between 600 and 1000 RCTs per year.

        **: Apart of course from the condition of hyperpecuniosis in the leathery structure called ‘the wallet’.

  • I am so confused. Is the first comment actually serious? I thought it was satire. And that the responses were following along in satire/sarcasm until it seemed they are actually responding to an actual serious comment?

    • DUllman meant his comment serious, no doubt – but that does not mean that people take hm seriously.

    • @Becky Alvarez
      This is a kind of little choreography routine that is played out every couple of weeks or so, every time when homeopathy comes up: first, Dana Ullman complains that Edzard and the other regulars here don’t take homeopathy seriously, saying that we don’t know what we’re talking about, ignore all the evidence etcetera yada yada yada.

      In return, he gets smacked around the head with lots of reasons why homeopathy doesn’t (appear to) do anything, that there is not a single homeopathic ‘remedy’ that reliably shows any effects whatsoever, and that no-one on this world can distinguish a homeopathic dilution from plain old water.

      After which once again silence ensues – that is, until the next time that homeopathy comes up of course.

    • Becky, the following article will, I think, leave you less confused:

      Dana Ullman, RationalWiki
      https://rationalwiki.org/wiki/Dana_Ullman

  • Drat, double drat and even a treble drat Dick Raskerly. It seems that there is still no lab that can determine shaken water from non shaken water. Anyway an impact factor of 6 is for me no good unless the journal is succusssed to a 6c.
    It might take Prof Pat Pending himself to find the nano particle break through. Dont worry when I get inside information on this break through I will inspired by current events place a bet and hold a party inviting all.

    I would have thought that the whacky idea of diluting something into oblivion with no justified mechanism of action would have resulted in the end of homeopathy once the research and media publicised this which happened years ago.
    Where did it all go wrong for the Slag brothers and Ant Hill mob?

  • Hi diddle diddle
    Talker talks in riddles

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