MD, PhD, FMedSci, FRSB, FRCP, FRCPEd.

Bioresonance is an alternative therapeutic and diagnostic method employing a device developed in Germany by Scientology member Franz Morell in 1977. The bioresonance machine was further developed and marketed by Morell’s son-in-law Erich Rasche and is also known as ‘MORA’ therapy (MOrell + RAsche). Bioresonance is based on the notion that one can diagnose and treat illness with electromagnetic waves and that, via resonance, such waves can influence disease on a cellular level.

On this blog, we have discussed the idiocy bioresonance several times (for instance, here and here). My favorite study of bioresonance is the one where German investigators showed that the device cannot even differentiate between living and non-living materials. Despite the lack of plausibility and proof of efficacy, research into bioresonance continues.

The aim of this study was to evaluate if bioresonance therapy can offer quantifiable results in patients with recurrent major depressive disorder and with mild, moderate, or severe depressive episodes.

The study included 140 patients suffering from depression, divided into three groups.

  • The first group (40 patients) received solely bioresonance therapy.
  • The second group (40 patients) received pharmacological treatment with antidepressants combined with bioresonance therapy.
  • The third group (60 patients) received solely pharmacological treatment with antidepressants.

The assessment of depression was made using the Hamilton Depression Rating Scale, with 17 items, at the beginning of the bioresonance treatment and the end of the five weeks of treatment.

The results showed a statistically significant difference for the treatment methods applied to the analyzed groups (p=0.0001). The authors also found that the therapy accelerates the healing process in patients with depressive disorders. Improvement was observed for the analyzed groups, with a decrease of the mean values between the initial and final phase of the level of depression, of delta for Hamilton score of 3.1, 3.8 and 2.3, respectively.

The authors concluded that the bioresonance therapy could be useful in the treatment of recurrent major depressive disorder with moderate depressive episodes independently or as a complementary therapy to antidepressants.

One could almost think that this is a reasonably sound study. But why did it generate such a surprising result?

When reading the full paper, the first thing one notices is that it is poorly presented and badly written. Thus there is much confusion and little clarity. The questions keep coming until one comes across this unexpected remark: the study was a retrospective study…

This explains some of the confusion and it certainly explains the surprising results. It remains unclear how the patients were selected/recruited but it is obvious that the groups were not comparable in several ways. It also becomes very clear that with the methodology used, one can make any nonsense look effective.

In the end, I am left with the impression that mutton is being presented as lamb, even worse: I think someone here is misleading us by trying to convince us that an utterly bogus therapy is effective. In my view, this study is as clear an example of scientific misconduct as I have seen for a long time.

3 Responses to Bioresonance: a new (and most underwhelming) study

  • Retrospective design of this sort of studies can be a way how to bypass legislative rules of clinical research. I don’t know how is it wordwide, but in my country (Czechia), retrospective analyses are out of scope of our regulatory agency (Státní ústav pro kontrolu léčiv) and ethical committee might approve only using or publishing of existing data instead of the study as whole.

  • Is “bioresonance therapy” even a definite technique? There are various different manufacturers.
    If “bioresonance therapy” isn’t well-defined, researchers could only test a bioresonance device from a particular manufacturer and say it works or it doesn’t.
    I’ve heard some of those machines don’t seem to be doing anything with their input, other than checking that it could plausibly come from a human being. If so, those machines would be just plain scams. No point in spending lots of research money testing *them* for efficacy.
    So is there some well-defined thing that “real” bioresonance therapy does with the input? Or do different manufacturers design the electrical circuits and software as they see fit?

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