MD, PhD, MAE, FMedSci, FRSB, FRCP, FRCPEd.

prevention

As we have discussed repeatedly, chiropractors tend to be critical of vaccinations. This attitude is easily traced back to DD Palmer, the founding father of chiropractic, who famously wrote about smallpox vaccinations: ‘…the monstrous delusion … fastened on us by the medical profession, enforced by the state boards, and supported by the mass of unthinking people …

In Canada, the anti-vaccination attitude of chiropractors has been the subject of recent media attention. Therefore, researchers explored the association between media attention and public dissemination of vaccination information on Canadian chiropractors’ websites.

In 2016, an international team of investigators identified all Canadian chiropractors’ websites that provided information on vaccination by extracting details from the regulatory college website for each province using the search engine on their “find a chiropractor” page. The researchers assessed the quality of information using the Web Resource Rating Tool (scores range from 0% [worst] to 100% [best]), determined whether vaccination was portrayed in a positive, neutral or negative manner, and conducted thematic analysis of vaccination content. Now the researchers have revisited all identified websites to explore the changes to posted vaccination material.

Here are their findings:

In July 2016, of 3733 chiropractic websites identified, 94 unique websites provided information on vaccination:

  • 59 (63%) gave negative messaging,
  • 19 (20%) were neutral,
  • 16 (17%) were positive.

The quality of vaccination content on the websites was generally poor, with a median Web Resource Rating Tool score of 19%. Four main themes were identified:

  1. there are alternatives to vaccination,
  2. vaccines are harmful,
  3. evidence regarding vaccination,
  4. health policy regarding vaccination.

From 2012 to 2016, there was one single Canadian newspaper story concerning anti-vaccination statements by chiropractors, whereas 51 news articles were published on this topic between 2017 and 2019. In April 2019, 45 (48%) of the 94 websites originally identified in 2016 had removed all vaccination content or had been discontinued.

The authors of this investigation concluded that in 2016, a minority of Canadian chiropractors provided vaccination information on their websites, the majority of which portrayed vaccination negatively. After substantial national media attention, about half of all vaccination material on chiropractors’ websites was removed within several years.

I find these findings encouraging. They demonstrate that media attention can produce change for the better. That gives me the necessary enthusiasm to carry on my work in putting the finger on the dangers of chiropractic and other forms of so-called alternative medicine (SCAM). At the same time, the findings of this investigation are also disappointing. About half of all the chiropractors had not removed their misleading content from their websites despite the 51 articles highlighting the problem. This shows, I think, how deeply entrenched this vitalistic nonsense is in the heads of many chiropractor.

This means there is still a lot to do – so, let’s get on with it!

In March, 2020, the International Chiropractors Association (ICA), a US based chiropractic organization, posted a report claiming that chiropractic adjustments can boost immune function with the implication that it might be helpful in preventing COVID-19. In their report, the ICA stated that: “Although there are no clinical trials to substantiate a direct causal relationship between the chiropractic adjustment and increased protection from the COVID-19 virus, there is a growing body of evidence that there is a relationship between the nervous system and the immune system” and “The observation that those who use chiropractic regularly and do not become ill with cold, flu, or other community shared illnesses is frequent within the profession and should not be ignored”.

Such misleading information is obviously unethical, irresponsible and dangerous. It prompted some chiropractors to do the research and find out what evidence exists that chiropractic might affect the immune system. They have now published their findings in a paper; here is its abstract:

Background

In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports.

Main body

We reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response.

Conclusion

In their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system.

It is not often that I praise the actions of chiropractors, I know. But today, I unreservedly applaud the above-quoted paper.

WELL DONE, AND THANK YOU.

(And while we are on the subject, may I encourage the authors to carry on their good work and do similar assessments of the rest of the hundreds of false claims made by so many of their colleagues day-in, day-out?)

 

Hard to believe but apparently true: it has been reported that the state government of Kerala distributed homeopathic medicines to people across the state as ‘immunity boosters’. A total of 4.5 million samples have already been distributed.

Map

No, these reports were not dated 1 April!

They are only two days old.

Dr. B Vijayakumar, a member of the State level expert group of the Indian Homoeopathic Medical Association (IHMA’s) revealed that homoeopathy has had a long history in treating and preventing epidemics ever since its inception including those such as Dengue, Chikungunya, Chickenpox and Typhoid. “Its effectiveness in the management of viral diseases has proved beyond doubt many a time. Homeopathy, being one of the most sought after the alternative system of medicine all over the world.”

VK Prasanth, MLA who has been the former mayor of Thiruvananthapuram was the first to launch the distribution of homeopathic medicine in his constituency. “The centre has recognised the homoeopathy medicine to boost the immunity and thereby work as a preventive. When I associated with it, first I was criticised, but now the medicine is in high demand across the state.” said Prasanth.

The Indian Homoeopathic Medical Association (IHMA) is part of the Kerala Government’s RAECH (Rapid Action Epidemic Control Cell, Homoeopathy) programme which officially looks after all the epidemic activities in Kerala.

The government of Kerala even has a ‘Department of Homeopathy. Its stated vision is:

  • Permanent establishment of Homoeopathic Health care facility to all Panchayaths in our state.
  • To open more specialities OP’S in vulnerable locations like coastal belt, tribal areas, metros etc. And Speciality IP’s In our district Hospitals.
  • To extent elaborate laboratory facilities in our district hospitals.
  • To formulate Research & Development wing in Department of Homoeopathy.
  • Computerization of all Dispensaries.
  • As per the Central Govt. Decision and Direction by Supreme Court primary Health care in the periphery i.e. Panchayats shall be designed in such a way that all the three systems i.e. Homoeopathy, Allopathy and Ayurveda Should come under one roof.

We have, of course, discussed the track record of homeopathy in epidemics before on this blog. It is simply not true that the evidence is convincing. It is also not true that homeopathy has ever been shown to boost any parameter indicative of the immune response. It is finally also untrue that there is good evidence that any homeopathic remedy is an effective treatment of any viral infection (or any other condition).

While many of us are wondering what SCAM will be promoted next for the corona pandemic, the editor of the infamous JCAM thought it wise to publish this note along with an article advertising the wonders of Ayurvedic medicine and yoga for the corona-virus entitled: ‘Public Health Approach of Ayurveda and Yoga for COVID-19 Prophylaxis‘.

Here are John Weeks’ remarks:

National governments are deeply divided over whether traditional, complementary and integrative practices have value for human beings relative to COVID-19. We witness a double standard. Medical doctors explore off-label uses of pharmaceutical agents that may have some suggestive research while evidence that indicates potential utility of natural products, practices and practitioners is often dismissed. In this Invited Commentary, a long-time JACM Editorial Board member Bhushan Patwardhan, PhD, from the AYUSH Center of Excellence, Center for Complementary and Integrative Health at the Savitribai Phule Pune University, India and colleagues from multiple institutions make a case for the potential roles of Ayurvedic medicine and Yoga as supportive measures in self-care and treatment. Patwardhan is a warrior for enhancing scientific standards in traditional medicine in India. Patwardhan was recently appointed by the Ministry of AYUSH, Government of India, as Chairman of an 18 member expert group known as “Interdisciplinary AYUSH Research and Development Taskforce” for initiating, coordinating and monitoring efforts against COVID-19. He was last seen here in an invited commentary entitled “Contesting Predators: Cleaning Up Trash in Science” (JACM, October 2019). We are pleased to have this opportunity to share the recommended approaches, the science, and the historic references as part of the global effort to leave no stone unturned in best preparing our populations to withstand COVID-19 and future viral threats. – John Weeks, Editor-in-Chief, JACM

His remarks are, I think, worthy of four very brief comments:

  1. As far as I can see, national governments and their advisors struggle to make sense of the rapidly changing situation. In all the confusion, they are, however, very clear about one thing: traditional, complementary and integrative practices have no real value for human beings relative to COVID-19.
  2. The double standards Weeks bemoans do not exist. There are dozens of studies currently on their way testing virtually any therapeutic option that shows even the smallest shimmer of hope. Testing implausible options only because some quacks feel neglected would be the last thing the world needs in the present situation.
  3. Weeks claims that ‘evidence that indicates potential utility of natural products, practices and practitioners is often dismissed’. What evidence? The article published alongside his remarks is free of what anyone with a thinking brain might call ‘evidence’. If there is evidence, Weeks or anyone else should approach the experts responsible for conducting the current trials; I am sure that they would listen and be only too happy to consider any reasonable option.
  4. The Indian Ministry of AYUSH has indeed been promoting all sorts of quackery for the corona-virus. This behaviour is likely to cause many fatalities in India. It should be squarely condemned and not promoted as Weeks seem to think.

Yes, you read this correctly: 2/3 of the German population revealed themselves to be stupid – at least this is what a survey sponsored by the German Association of Homeopathic Doctors seems to imply.

Hard to believe?

Well, read the press-release for yourself [and if you are not reading German, let me fill you in below]:

Fast zwei Drittel der Bevölkerung in Deutschland würde den Einsatz homöopathischer Arzneimittel zur Behandlung von Covid-19-Erkrankungen befürworten.

Das ist eines von mehreren Ergebnissen einer repräsentativen Umfrage des Instituts für Politik- und Sozialforschung forsa, durchgeführt im Auftrag des Deutschen Zentralvereins homöopathischer Ärzte.

Angst vor Covid-19. Interesse an homöopathischen Methoden.

Befragt wurden insgesamt 1009 Bundesbürger, unter anderem zum Grad ihrer Besorgnis vor einer Erkrankung an Covid-19, ihrem Interesse an Vorsorgemaßnahmen gegen eine Corona-Infektion zusätzlich zu besonderer Hygiene, ihrer Einstellung zu einer Behandlung von Covid-19 mit homöopathischen Arzneimitteln, sowie zur Befürwortung oder Ablehnung staatlicher finanzieller Förderung von Forschungsprojekten zu homöopathischen Vorsorge- und Behandlungsmethoden von Covid-19-Erkrankungen.

61% ziehen homöopathische Behandlung mindestens ernsthaft in Betracht

Mehr als die Hälfte aller Befragten hat bereits Erfahrung mit einer homöopathischen Behandlung bei früheren Erkrankungen gemacht. Noch mehr, nämlich fast zwei Drittel aller Befragten, würden unter der Voraussetzung, dass es in der Vergangenheit schon positive Erfahrungen mit diesem Mittel gab, im Fall einer Erkrankung an Covid-19 eine homöopathische Behandlung für sich selbst oder ihnen nahestehenden Personen auf jeden Fall (26 %) oder eher (34 %) befürworten

Homöopathie soll auch Gelder für Forschungsprojekte erhalten

Auch hinsichtlich der weiteren Erforschung von Methoden zur Vorbeugung gegen eine Infektion mit dem Corona-Virus und der Behandlung von Covid-19 fänden es viele Bürger (42 %) in Deutschland gut oder sehr gut- in der Altersgruppe über 45 Jahren sogar rund oder mehr als die Hälfte – dass staatliche Gelder nicht nur in Forschungsprojekte der konventionellen Medizin gesteckt werden, sondern dass auch Projekte der homöopathischen Medizin gezielt gefördert werden.

Here is the gist of the press-release for non-German speakers:

The German Association of Homeopathic Doctors paid an otherwise respectable agency to run a poll for them; not just any poll, but one that is robust enough to be representative of the entire German population (sample size of 1009!). The questions asked were about homeopathy in the present health crisis. The results show that:

  • 61% would seriously consider using homeopathy,
  • more than 50% have had positive experience with homeopathy during previous episodes of illness,
  • more than 2/3 would consider homeopathy for a corona-virus infection, provided that there has been positive experience with this approach in the past,
  • 42% of Germans would find it good or very good, if public funds would also be dedicated to research in homeopathy.

What does that tell us?

It tells us that the Germans are not that stupid after all: they would only consider homeopathy for a corona-virus infection, if there has been positive experience with this approach in the past. As such positive evidence is absent, they would not consider homeopathy!

The poll also tells us that surveys can be spun to generate the most idiotic findings provided the questions that are being asked are phrased in a sufficiently leading way. It moreover tells us that the German Association of Homeopathic Doctors seem to believe that Germans are stupid and do not realise that this survey is a despicable stunt for boosting their failing business. Finally, it tells us that the German Association of Homeopathic Doctors are behaving grossly unethical to promote homeopathy during this pandemic. There is not a jot of evidence that homeopathy might be effective and a lot of evidence to show that promoting useless treatments is dangerous.

Many experts are wondering whether it is possible to stimulate our immune system such that we are better protected against getting infected with the coronavirus. Several options have been considered.

An innovative approach, for instance, seems to be this one:

Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. Immunotherapy with IVIg could be employed to neutralize COVID-19. However, the efficacy of IVIg would be better if the immune IgG antibodies were collected from patients who have recovered from COVID-19 in the same city, or the surrounding area, in order to increase the chance of neutralizing the virus. These immune IgG antibodies will be specific against COVID-19 by boosting the immune response in newly infected patients. Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available.

Another suggestion involves monoclonal antibodies:

The therapeutic potential of monoclonal antibodies has been well recognized in the treatment of many diseases. Here, we summarize the potential monoclonal antibody based therapeutic intervention for COVID-19 by considering the existing knowledge on the neutralizing monoclonal antibodies against similar coronaviruses SARS-CoV and MERS-CoV. Further research on COVID-19 pathogenesis could identify appropriate therapeutic targets to develop specific anti-virals against this newly emerging pathogen.

These and several further options have in common that they are not backed by robust clinical evidence. Such a lack of data rarely bothers charlatans who use the corona-panic for promoting their bizarre concepts. Numerous promoters of so-called alternative medicine (SCAM) are trying their very best to mislead the public into thinking that their particular SCAM will do the trick.

In comes the PYROMANIAC IN A FIELD OF (INTEGRATIVE) STRAW-MEN, Dr Michael Dixon who recently proclaimed that ‘boosting immunity against coronavirus: ‘Now’s the time to turn to antioxidants and polyphenols’. Specifically, he recommended:

‘Eat dark greens, broccoli, spinach or any coloured root vegetable such as beetroot or carrots and any fruit ending in the word berry; black, blue… The alliums, such as leeks and garlic and onions, are very strong in the same sort of chemicals and also even things like dark chocolate and certain teas, particularly green tea. Those who want a glass of red wine, well that’s something that’s very much permitted too.’

Inspired by such positive thinking, I ventured to find some evidence for Dixon’s infinite wisdom. It could be that I am not very gifted at locating evidence – or perhaps there isn’t any?

Well, not quite; there is some on garlic that Dixon praises for its immune-boosting activity. Here is the abstract of a Cochrane review:

Background

Garlic is alleged to have antimicrobial and antiviral properties that relieve the common cold, among other beneficial effects. There is widespread usage of garlic supplements. The common cold is associated with significant morbidity and economic consequences. On average, children have six to eight colds per year and adults have two to four.

Objectives

To determine whether garlic (Allium sativum) is effective for the prevention or treatment of the common cold, when compared to placebo, no treatment or other treatments.

Search methods

We searched CENTRAL (2014, Issue 7),OLDMEDLINE (1950 to 1965),MEDLINE (January 1966 to July week 5, 2014), EMBASE(1974 to August 2014) and AMED (1985 to August 2014).

Selection criteria

Randomised controlled trials of common cold prevention and treatment comparing garlic with placebo, no treatment or standard treatment.

Data collection and analysis

Two review authors independently reviewed and selected trials from searches, assessed and rated study quality and extracted relevant data.

Main results

In this updated review, we identified eight trials as potentially relevant from our searches. Again, only one trial met the inclusion criteria. This trial randomly assigned 146 participants to either a garlic supplement (with 180 mg of allicin content) or a placebo (once daily)for 12 weeks. The trial reported 24 occurrences of the common cold in the garlic intervention group compared with 65 in the placebo group (P value < 0.001), resulting in fewer days of illness in the garlic group compared with the placebo group (111 versus 366). The number of days to recovery from an occurrence of the common cold was similar in both groups (4.63 versus 5.63). Only one trial met the inclusion criteria, therefore limited conclusions can be drawn. The trial relied on self reported episodes of the common cold but was of reasonable quality in terms of randomisation and allocation concealment. Adverse effects included rash and odour.

Authors’ conclusions

There is insufficient clinical trial evidence regarding the effects of garlic in preventing or treating the common cold. A single trial suggested that garlic may prevent occurrences of the common cold but more studies are needed to validate this finding. Claims of effectiveness appear to rely largely on poor-quality evidence.

Of course, this is not about corona but about the common cold. As for green tea, a recent review found a lack of reliable clinical data demonstrating its immune-boosting activities, a deficit also noted for chocolate.

But where IS the evidence that any of the above claims are true?

Could it be that there is no sound evidence to support Dixon’s recommendations?

Impossible!!!

That would mean that Dixon, advisor to Prince Charles, is stating nonsense in the name of his COLLEGE OF MEDICINE AND INTEGRATED HEALTH. This organisation has many very respectable people as members and officers. They would never allow that sort of thing to happen!

Or would they?

Am I the only one who suspects that China is using the current pandemic for promoting Traditional Chinese Medicine? I see many signs for that being so. To me, this seems not better than pushing homeopathy for that purpose. The fact is, I fear, that there is no robust evidence that TCM works for corona or any other viral infection. In case you think I am wrong, please show me the studies.

Anyway, in this context, it seems relevant to ask to what extend TCM has been used so far in the battle against the current pandemic. I came across this website which gives us some clues. I have no idea how reliable the data are, so perhaps one needs to take them with a pinch of salt. Here they are (% figures depict the usage of TCM):

US – 1%

Europe – 2%

Italy – 3%

Spain – 2%

UK – 0%

France – 6%

Germany – o%

China – 67%

Korea/Taiwan/Japan – 10%

Rest of the world – 3%

And what do these figures tell us?

Probably not a lot!

But they are nevertheless interesting, I think, in that they suggest that China’s promotion of TCM has had some moderate successes at least in some countries; notably France and Asian regions seem to have succumbed to the Chinese sales techniques to some degree . Remarkable, in my view, is also the German’s absolute resistance to use TCM. Considering that Germany has an enviably low death rate, this fact seems to somewhat dispel the notion that TCM offers an effective way out of the current health crisis.

I know Dr Thompson personally since many years. She is one of the UK’s leading homeopaths and we rarely agreed on anything. Yet I had always considered her to be on the responsible side of the homeopathic spectrum. I am sorry to say that I just changed my mind.

The reason is this video and letter.

In the video, she explains that she has been infected with the coronavirus, has self-treated the condition with homeopathy and promptly recovered. In the letter to all patients, she states the following:

… In terms of Homeopathic Medicines, the medicine Anas Barb 200c, two tablets twice weekly, can be used during this time, increasing to two tablets once a day if you do have exposure to the virus or have symptoms and have to self-isolate.

Other Homeopathic Medicines that are being recommended include:

  • Arsenicum Album 30c: three times daily if anxiety is strong
  • Gelsemium 30c: twice daily if weakness and headache predominate
  • Bryonia 30c: two-three times a day for dry cough particularly if movement aggravates the cough.

If cough becomes more problematic you can use Antimonium Tartaricum 30c three times daily.

If fevers are a problem and particularly if they are periodic (coming at certain times of the day) use China officinalis 30c three times daily…

I find this amazing and alarming. There is, of course, not a jot of evidence that any homeopathic treatment will effectively treat or prevent any viral infection, and certainly no evidence that it cures coronavirus infections. To claim or imply otherwise displays a staggering ineptitude and lack of professionalism. To extrapolate from a personal experience to a quasi recommendation for patients is, in my view, ridiculously unscientific and overtly unethical. As a doctor Thompson should be able to differentiate between experience and evidence and has the professional duty to go by the latter.

I am truly glad to hear that Dr Thompson has had a mild course of the disease and recovered swiftly. But we know that all too often this is not the case and that patients can become seriously ill and some even die of the coronavirus. To give the impression that homeopathy can keep them safe is clearly both incorrect and irresponsible.

As THE TIMES stated yesterday, homeopaths are ‘risking lives with bogus coronavirus treatments’.

It’s high time to stop them.

Wouldn’t it be wonderful, if we had a treatment that reduces the risk of getting infected with the corona-virus? Well, this paper claims that there is one. Here is its abstract:

Since December 2019, an outbreak of corona virus disease 2019 (COVID-19) occurred in Wuhan, and rapidly spread to almost all parts of China. This was followed by prevention programs recommending Chinese medicine (CM) for the prevention. In order to provide evidence for CM recommendations, we reviewed ancient classics and human studies.

Methods

Historical records on prevention and treatment of infections in CM classics, clinical evidence of CM on the prevention of severe acute respiratory syndrome (SARS) and H1N1 influenza, and CM prevention programs issued by health authorities in China since the COVID-19 outbreak were retrieved from different databases and websites till 12 February, 2020. Research evidence included data from clinical trials, cohort or other population studies using CM for preventing contagious respiratory virus diseases.

Results

The use of CM to prevent epidemics of infectious diseases was traced back to ancient Chinese practice cited in Huangdi’s Internal Classic (Huang Di Nei Jing) where preventive effects were recorded. There were 3 studies using CM for prevention of SARS and 4 studies for H1N1 influenza. None of the participants who took CM contracted SARS in the 3 studies. The infection rate of H1N1 influenza in the CM group was significantly lower than the non-CM group (relative risk 0.36, 95% confidence interval 0.24–0.52; n=4). For prevention of COVID-19, 23 provinces in China issued CM programs. The main principles of CM use were to tonify qi to protect from external pathogens, disperse wind and discharge heat, and resolve dampness. The most frequently used herbs included Radix astragali (Huangqi), Radix glycyrrhizae (Gancao), Radix saposhnikoviae (Fangfeng), Rhizoma Atractylodis Macrocephalae (Baizhu), Lonicerae Japonicae Flos (Jinyinhua), and Fructus forsythia (Lianqiao).

Conclusions

Based on historical records and human evidence of SARS and H1N1 influenza prevention, Chinese herbal formula could be an alternative approach for prevention of COVID-19 in high-risk population. Prospective, rigorous population studies are warranted to confirm the potential preventive effect of CM.

So, what should we make of this conclusion?

To provide an evidence-based answer, I tried to look up the original studies cited in the article. The links provided by the authors seem to be all dead except one which leads to a paper published in the infamous JCAM. Here is its abstract:

Objectives: To investigate the efficacy of an herbal formula in the prevention of severe acute respiratory syndrome (SARS) transmission among health care workers. The secondary objectives are to investigate quality of life (QOL) and symptomology changes among supplement users, and to evaluate the safety of this formula.

Design: Controlled clinical trial.

Settings: Hong Kong during epidemic of SARS.

Subjects: Two cohorts of health care workers from 11 hospitals in Hong Kong, 1 using an herbal supplement for a 2-week period (n = 1063) and a control cohort comprising all other health care workers who did not receive the supplement (n = 36,111) were compared prospectively.

Interventions: Taking an herbal supplement for a 2-week period.

Outcome measures: SARS attack rates and changes in quality of life and influenza-like symptoms were also examined at three timepoints among herbal supplement users.

Results: None of the health care workers who used the supplement subsequently contracted SARS compared to 0.4% of the health care workers who did not use the supplement (p = 0.014). Improvements in influenza-like symptoms and quality of life measurements were also observed among herbal supplement users. Less than 2% reported minor adverse events.

Conclusion: The results of this pilot study suggest that there is a good potential of using Traditional Chinese Medicine (TCM) supplements to prevent the spread of SARS.

How can I be polite and still say what I think about this article? Perhaps by stating this: THIS STUDY WAS INCAPABLE OF INVESTIGATING THE ‘EFFICACY’ OF ANYTHING AND ITS RESULTS ARE NOT CONVINCING.

So, are the Chinese authors correct when concluding that Chinese herbal formula could be an alternative approach for prevention of COVID-19 in high-risk population?

No, I don’t think so! And I even feel that it is irresponsible in the current situation to misguide consumers, patients, scientists and decision-makers into believing that TCM offers an answer to the pandemic.

 

When I first saw this press-release, I thought it was a hoax. After all, it came from a most dubious homeopathic source. Then I read it again and was no longer sure.

What do you think?

Here it is in full:

Santa Clara, Cuba, April 3,2020 (Prensa Latina) The homeopathic medicine Prevengho-VIR began to be administered as a measure to confront the Covid-19 in this province of central Cuba.

Dr. Mirtha Rosa Hernandez, head of the Department of the Elderly in Villa Clara, reported that the supply of the preparation began in the Grandparents’ Homes and Elderly Homes of the territory, which has 184,000 people over 60 years old, 23.9 percent of the local universe. The medicine is administered by doctors and nurses of the basic working group where the Grandparents’ Homes and Nursing Homes are located in the 13 municipalities of this province.

This homeopathic medicine comes in a 10-milliliter bottle, and the daily dosage is 5 drops, thrice a day; while on the tenth day a reactivation of the initial dose is performed. It is aimed at preventing the respiratory diseases in this risk group, in addition to other medical conditions, such as dengue.

In the upcoming days it will be extended to the Maternal Homes. It is administered by the doctors and the nurses from the basic work group of the senior homes.

She said, that besides avoiding the new coronavirus the formula is also aimed at preventing respiratory diseases in this risk group, in addition to others such as dengue fever.

This medicine can also be administered to children under 10 years old, pregnant women, nursing mothers, and patients with liver disorders.

Combination Medicine
Anas berberiae 200
Baptisia tinctora 200
Bascilinum 30
Pyrogenum 200
Eupetorium perf 200
Influezinum 200
Arsenicum Album 200

As I said, I was not sure whether this was for real. Is it possible that even officials are so stupid, brainwashed or gullible to go for homeopathy in such a serious situation?

In an attempt to find out, I did a little search and quickly found that the story has been reported by multiple media. This, for instance, is what the Miami Herald reported:

As scientists around the world speed up clinical trials to find a cure or vaccine for the coronavirus, the Cuban government will begin distributing a homeopathic remedy to the elderly and other vulnerable people to “prevent” the spread of the disease, a top health official said.

Dr. Francisco Durán, national director of Epidemiology at the Ministry of Public Health, said in a press conference on Sunday that “sublingual drops” of the compound PrevengHo-Vir “prevent different diseases such as influenza, the common cold, dengue, and emerging viral infections such as this one.”

On Monday, Durán tried to correct his statements and said that the product “does not prevent contagion” but rather “increases resistance, the body’s defenses against a certain virus.”

Several state media outlets reported that PrevengHo-Vir is already being used in various Cuban provinces to treat the elderly and other groups vulnerable to the coronavirus. There is no internet record of PrevengHo-Vir, other than press reports about the announcement of its distribution in Cuba.

So, it’s not a hoax!

In this case, let me try to predict what will happen next:

  • When the pandemic is over, the Cubans will publish mortality rates achieved with their homeopathic prevention [A].
  • They will compare them to data from a cohort that did not receive the homeopathic treatment [B].
  • Neither of the data-sets will be transparent and nobody will be able to check its reliability.
  • The comparison will yield a significant difference in favour of homeopathy.
  • The Cubans will use this to market their remedy.
  • The world of homeopathy will use it as a proof that homeopathy is effective (it wouldn’t be the first time).

Nothing wrong with that, some will say. Others who understand research methodology will, however, point out that these data are less than convincing.

In such case/control studies, one large group of patients [A] is compared to another group [B]. Group A has been treated homeopathically, while group B received no homeopathy. Any difference in outcome between A and B might be due to a range of circumstances that are unrelated to the homeopathic treatment, for instance:

  • group A might have been less ill than group B,
  • group A might have been better nourished,
  • group A might have benefited from better hygiene,
  • group A might have received better care,
  • group B might have received treatments that made the situation not better but worse,
  • the researchers might have prettified the data to make group A look better.

Such concerns are not totally unfounded; after all, Cuba seems to have a long history of making irresponsible claims for their homeopathic products.

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