MD, PhD, MAE, FMedSci, FRSB, FRCP, FRCPEd.

critical thinking

Research into both receptivity to falling for bullshit and the propensity to produce it have recently emerged as active, independent areas of inquiry into the spread of misleading information. However, it remains unclear whether those who frequently produce bullshit are inoculated from its influence. For example, both bullshit receptivity and bullshitting frequency are negatively related to cognitive ability and aspects of analytic thinking style, suggesting that those who frequently engage in bullshitting may be more likely to fall for bullshit. However, separate research suggests that individuals who frequently engage in deception are better at detecting it, thus leading to the possibility that frequent bullshitters may be less likely to fall for bullshit.

Canadian psychologists conducted three studies (N = 826) attempting to distinguish between these competing hypotheses, finding that frequency of persuasive bullshitting (i.e., bullshitting intended to impress or persuade others) positively predicts susceptibility to various types of misleading information and that this association is robust to individual differences in cognitive ability and analytic cognitive style.

This seems to make sense – at least in the contest of so-called alternative medicine (SCAM). Those promoting bullshit are the ones that fall for bullshit.

Think of Prince Charles, for instance. In his book HARMONY and on many other occasions he insists on promoting homeopathy and other SCAM, like for example iridology, osteopathy or detox. He even advocates homeopathy for animals and he proudly tells us that, on his farms, he has instructed the personnel to give his cows homeopathy. Thus he is a good example of someone who is frequently bullshitting with the intend to impress or persuade others while, at the same time, being highly susceptible to various other types of misleading information, such as iridology.

Charles is a good example because we all know about the alternative bee under the royal bonnet. But he is certainly not alone, quite to the contrary. If you look around you, I am sure you will find that there are no end of bullshitters who fall for bullshit. Before bullshit became a term used even in scientific journals, they used to say ‘one can never kid a kidder’, but the new research by the Canadian psychologists seems to suggest that the assumption is not entirely correct.

I was reminded of an event that I had forgotten which, however, is so remarkable that we should remember it. It relates to nothing less than a homeopath’s attempt to save the world!

The homeopath’s name is Grace DaSilva-Hill. She has been a professional homeopath since 1997, with a clinic in Charing (Kent) and international on Zoom, Skype or WhatsApp video. She practises Sensation Homeopathy as refined by Drs Joshis (Mumbai), and Homeopathic Detox Therapy as developed by Dr Ton Jensen. She is also a practitioner of EFT-Tapping. In 2014, Grace very nearly saved the world with homeopathy – well, at least she gave it her very best try. Here is her original plan:

 

Ocean Remedy

Yes, I agree, that’s hilarious! And it’s hilarious in more than one way:

  1. It is funnier than any comedian’s attempt to ridicule homeopathy.
  2. It is a highly effective approach by homeopaths to discrediting themselves.

But, at the same time, it is also worrying. Homeopaths are taken seriously by many influential people. Think of Prince Charles, for instance, or consider the way German homeopaths have convinced the government of Bavaria to invest in research into the question of how homeopathy can be used to reduce antibiotic resistance.

At the time, the formidable Andy Lewis on his QUACKOMETER commented as follows:

We might dismiss this as the fantasies of a small group of homeopaths. However, such thinking is widespread in homeopathic circles and has consequences. Grace is a well known homeopath in the UK, and in the past, has been a trustee and treasurer for the Ghana Homeopathy Project – an organisation that has been exporting this European form of quackery to West Africa. Grace believes that serious illnesses can be treated by a homeopath. For an article in the journal of the Alliance of Registered Homeoapths, Grace discusses treating such conditions as menigitis, malaria and stroke.

Homeopaths in West Africa have hit the news this week as a group tried to enter Liberia in order to use their spells on people with Ebola. The WHO fortunately tried not let them near any actual sick people and they have been kicking and screaming since. The Daily Mail’s rather dreadful article reported that they

“had used homeopathic treatments on patients, despite the instructions from health officials in the capital Monrovia not to do so. She said she had not felt the need to quarantine herself after returning to India but was monitoring her own condition for any signs of the disease.”

The homeopaths appear to have absolutely no understanding how dangerous and irresponsible their actions have been….

Homeopathy is stupid. Magical thinking. A nonsense. Anything goes. And whilst those doctors in the NHS who insist on spending public money on it without taking a responsible stand against the common and dangerous excesses, they can expect to remain under constant fire from those who think they are doing a great deal of harm.

Meanwhile, the public funding of homeopathy in England has stopped; France followed suit. Surely Grace’s invaluable help in these achievements needs to be acknowledged! If we regularly remind decision-makers and the general public of Grace’s attempt to save the world and similarly barmy things homeopaths are up to, perhaps the rest of the world will speed up the process of realizing the truth about homeopathy!?

The author of this study introduces the subject by stating that Reiki is a biofield energy therapy that focuses on optimizing the body’s natural healing abilities balancing the life force energy or qi/chi. Reiki has been shown to reduce stress, pain levels, help with depression/anxiety, increase relaxation, improve fatigue, and quality of life.

Despite the fact that the author seems to have no doubt about the effectiveness of Reiki, she decided single-handedly to conduct a study of it – well, not a real study but a ‘pilot study’:

In this pilot randomized, double-blinded, and placebo-controlled study, the effects of Reiki on heart rate, diastolic and systolic blood pressure, body temperature, and stress levels were explored in an effort to gain objective outcome measures and to understand the underlying physiological mechanisms of how Reiki may be having these therapeutic effects on subjective measures of stress, pain, relaxation, and depression/anxiety.

Forty-eight subjects were block-randomized into three groups (Reiki treatment, sham treatment, and no treatment). The changes in pre-and post-treatment measurements for each outcome measure were analyzed through analysis of variance (ANOVA) post hoc multiple comparison test, which found no statistically significant difference between any of the groups. The p-value for the comparison of Reiki and sham groups for heart rate was 0.053, which is very close to being significant and so, a definitive conclusion can not be made based on this pilot study alone.

The author concluded that a second study with a larger sample size is warranted to investigate this finding further and perhaps with additional outcome measures to look at other possible physiological mechanisms that may underlie the therapeutic effects of Reiki.

I have a few questions about this paper:

  • If a researcher already knows that a treatment works, why do a study?
  • If she nevertheless does a study, why a pilot that is not meant for evaluating effects but for testing the feasibility?
  • Why does the author calculate effects instead of evaluating the feasibility of his project?
  • Why does the author try to interpret a negative outcome as though it signifies an almost positive effect?
  • Why did someone who knows how to do research at the Ohio Wesleyan University (the author’s affiliation) not give her some guidance?
  • Why did the reviewers of this paper let it pass?
  • Why does any journal publish such rubbish?

Oh, the embarrassment!

It’s a journal for which I once (a long time ago) served on the editorial board.

This study compared the effectiveness of two osteopathic manipulative techniques on clinical low back symptoms and trunk neuromuscular postural control in male workers with chronic low back pain (CLBP).

Ten male workers with CLBP were randomly allocated to two groups: high-velocity low-amplitude (HVLA) manipulation or muscle energy techniques (MET). Each group received one therapy per week for both techniques during 7 weeks of treatment.

Pain and function were measured by using the Numeric Pain-Rating Scale, the McGill Pain Questionnaire, and the Roland Morris Disability Questionnaire. The lumbar flexibility was assessed by Modified Schober Test. Electromyography (EMG) and force platform measurements were used for evaluation of trunk muscular activation and postural balance, respectively at three different times: baseline, post-intervention, and 15 days later.

Both techniques were effective (p < 0.01) in reducing pain with large clinical differences (-1.8 to -2.8) across immediate and after 15 days. However, no significant effect between groups and times was found for other variables, namely neuromuscular activation, and postural balance measures.

The authors concluded that both techniques (HVLA thrust manipulation and MET) were effective in reducing back pain immediately and 15 days later. Neither technique changed the trunk neuromuscular activation patterns nor postural balance in male workers with LBP.

There is, of course, another conclusion that fits the data just as well: both techniques were equally ineffective.

A report just published by the UK GENERAL CHIROPRACTIC COUNCIL (the regulator of chiropractors in the UK) entitled Public perceptions research Enhancing professionalism, February 2021 makes interesting reading. It is based on a consumer survey for which the national online public survey was conducted by djs research in 2020 with a nationally representative sample of 1,002 UK adults (aged 16+). From this sample, 243 UK adults had received chiropractic treatment and were surveyed on their experiences of visiting a chiropractor.

Hidden amongst intensely boring stuff, we find a heading entitled Communicating potential risks. This caught my interest. Here is the unabbreviated section:

The findings show that patients want to understand the potential risks of treatment – alongside information on cost, this is the most important factor for patients considering chiropractic care. In fact, having any risks communicated before embarking on treatment scores 83 out of 100 on a scale of importance.

Many patients report receiving this information from their chiropractor. Seventy per cent of those who have received chiropractic treatment agree that risks were communicated before treatment commenced.

What does that suggest?

  1. Patients want to know about the risks of the treatments chiropractors administer.
  2. 30% of all patients are not being given this information.

This roughly confirms what has long been known:

MANY CHIROPRACTORS DO NOT OBTAIN INFORMED CONSENT FROM THEIR PATIENTS AND THUS VIOLATE MEDICAL ETHICS.

The questions that arise from this information are these:

  1. As the GCC has long known about this situation, why have they not adequately addressed it?
  2. Now that they are reminded of this flagrant ethical violation, what are they planning to do about it?
  3. What measures will they put in place to make sure that all chiropractors observe the elementary rules of medical ethics in the future?
  4. What reprimands do they plan for members who do not comply?

Two recent reviews have evaluated the evidence for acupuncture as a means of preventing migraine attacks.

The first review assessed the efficacy and safety of acupuncture for the prophylaxis of episodic or chronic migraine in adult patients compared to pharmacological treatment.

The authors included randomized controlled trials published in western languages that compared any treatment involving needle insertion (with or without manual or electrical stimulation) at acupuncture points, pain points or trigger points, with any pharmacological prophylaxis in adult (≥18 years) with chronic or episodic migraine with or without aura according to the criteria of the International Headache Society.

Nine randomized trials were included encompassing 1,484 patients. At the end of the intervention, a small reduction was found in favor of acupuncture for the number of days with migraine per month: (SMD: -0.37; 95% CI -1.64 to -0.11), and for response rate (RR: 1.46; 95% CI 1.16-1.84). A moderate effect emerged in the reduction of pain intensity in favor of acupuncture (SMD: -0.36; 95% CI -0.60 to -0.13), and a large reduction in favor of acupuncture in both the dropout rate due to any reason (RR 0.39; 95% CI 0.18 to 0.84) and the dropout rate due to adverse event (RR 0.26; 95% CI 0.09 to 0.74). The quality of the evidence was moderate for all these primary outcomes. Results at longest follow-up confirmed these effects.

The authors concluded that, based on moderate certainty of evidence, we conclude that acupuncture is mildly more effective and much safer than medication for the prophylaxis of migraine.

 

The second review aimed to perform a network meta-analysis to compare the effectiveness and acceptability between topiramate, acupuncture, and Botulinum neurotoxin A (BoNT-A).

The authors searched OVID Medline, Embase, the Cochrane register of controlled trials (CENTRAL), the Chinese Clinical Trial Register, and clinicaltrials.gov for randomized controlled trials (RCTs) that compared topiramate, acupuncture, and BoNT-A with any of them or placebo in the preventive treatment of chronic migraine. A network meta-analysis was performed by using a frequentist approach and a random-effects model. The primary outcomes were the reduction in monthly headache days and monthly migraine days at week 12. Acceptability was defined as the number of dropouts owing to adverse events.

A total of 15 RCTs (n = 2545) could be included. Eleven RCTs were at low risk of bias. The network meta-analyses (n = 2061) showed that acupuncture (2061 participants; standardized mean difference [SMD] -1.61, 95% CI: -2.35 to -0.87) and topiramate (582 participants; SMD -0.4, 95% CI: -0.75 to -0.04) ranked the most effective in the reduction of monthly headache days and migraine days, respectively; but they were not significantly superior over BoNT-A. Topiramate caused the most treatment-related adverse events and the highest rate of dropouts owing to adverse events.

The authors concluded that Topiramate and acupuncture were not superior over BoNT-A; BoNT-A was still the primary preventive treatment of chronic migraine. Large-scale RCTs with direct comparison of these three treatments are warranted to verify the findings.

Unquestionably, these are interesting findings. How reliable are they? Acupuncture trials are in several ways notoriously tricky, and many of the primary studies were of poor quality. This means the results are not as reliable as one would hope. Yet, it seems to me that migraine prevention is one of the indications where the evidence for acupuncture is strongest.

A second question might be practicability. How realistic is it for a patient to receive regular acupuncture sessions for migraine prevention? And finally, we might ask how cost-effective acupuncture is for that purpose and how its cost-effectiveness compares to other options.

On 20 February 2021, I published on my blog a comment on a new study of an Ayurvedic remedy for COVID-19. The study was in my view suspect, and I expressed this as follows:

I have the following concerns or questions about this trial:

  • Why do the authors call it a pilot study? A pilot study is merely for testing the feasibility of a trial design and is not meant to yield definitive efficacy results.
  • The authors state that the patients were asymptomatic yet in the discussion they claim they were asymptomatic or mildly symptomatic.
  • Some of the effect sizes reported here are extraordinary and seem almost too good to be true.
  • The claim of no adverse effect is implausible; even placebos would cause perceived adverse effects in a percentage of patients.
  • If the study is solid and withstands the scrutiny of the raw data, it is of huge relevance for public health. So, why did the authors publish it in PHYTOMEDICINE, a relatively minor and little-known journal?

An article in The Economic Times’ reported this:

Patanjali Ayurved released what it called the first “evidence-based” medicine for Covid-19 on Friday. It claimed it has been “recognised by the WHO (World Health Organization) as an ayurvedic medicine for corona”. Patanjali promoter, yoga guru Baba Ramdev, released a scientific research paper in this regard at the launch, presided over by Union health minister Harsh Vardhan and transport minister Nitin Gadkari. The Ayurveda products maker said it has received a certification from the Ayush ministry. “Coronil has received the Certificate of Pharmaceutical Product (CoPP) from the Ayush section of Central Drugs Standard Control Organisation (CDSCO) as per the WHO certification scheme,” it said in a statement. Under the CoPP, Coronil can be exported to 158 countries, the company said, adding that based on the presented data, the ministry has recognised Coronil as medicine for “supporting measure in Covid-19”.

Am I the only one who fears that something is not entirely kosher about the study? (This is an honest question, and I would be pleased to receive answers from my readers)

What happened next is most puzzling. After putting it on Facebook several times, I got banned for 72 hours from posting this article or anything else on Facebook. When this period had elapsed, I put the article in question again on Facebook. Subsequently, I was banned again but this time for 7 days. Facebook gave the following explanation:

You can’t post or comment for 7 days

This is because your previous posts didn’t follow our Community Standards.

No one else can see these posts.

1 Mar

Your post goes against our Community Standards on misinformation that could cause physical harm

We usually offer the chance to request a review, and follow up if we’ve gotten decisions wrong.

We have fewer reviewers available at the moment because of the coronavirus (COVID-19) outbreak. We’re trying hard to prioritise reviewing content with the most potential for harm.

This means that we may not be able to follow up with you, though your feedback helps us do better in the future.

Thank you for understanding.

On Twitter, the hype had begun even before its text was available. Priti Gandhi, for instance, tweeted:

Yet another feather in India’s cap!! 1st evidence-based, CoPP-WHO GMP certified medicine for Covid-19 released today. Congratulations to @yogrishiramdev ji, @Ach_Balkrishna ji & the team of scie…

EDZARDERNST.COM An RCT on the efficacy of ayurvedic treatment on asymptomatic COVID-19 patients

________________________________

As I did not feel I had broken any rules, I protested against the bans each time. When the 2nd ban was over, I posted my article yet again and, sure enough, yesterday I got banned again, this time for 30 days. Here is how they let me know:

You can’t post or comment for 30 days

This is because you previously posted something that didn’t follow our Community Standards.

This post goes against our standards on misinformation that could cause physical harm, so only you can see it.

Learn more about updates to our standards. On Twitter, the hype had begun even before its text was available. Priti Gandhi, for instance, tweeted: Yet another feather in India’s cap!! 1st evidence-based, CoPP-WHO GMP certified medicine for Covid-19 released today. Congratulations to @yogrishiramdev ji, @Ach_Balkrishna ji & the team of scie…

EDZARDERNST.COM An RCT on the efficacy of ayurvedic treatment on asymptomatic COVID-19 patients

____________________________

As the reason for the ban always seems to be the Ayurvedic study, I suspect that some party interested in the product is behind the complaints that lead to the bans. I find it extraordinary that I can be banned repeatedly without having done anything wrong and without my objections ever being considered.

Has anyone else experienced similar things?
Can anyone shed more light on this mysterious story?
Is there anything I can do, except for objecting, which I have now done thrice?

This recent article is truly remarkable:

There is a faction within the chiropractic profession passionately advocating against the routine use of X-rays in the diagnosis, treatment and management of patients with spinal disorders (aka subluxation). These activists reiterate common false statements such as “there is no evidence” for biomechanical spine assessment by X-ray, “there are no guidelines” supporting routine imaging, and also promulgate the reiterating narrative that “X-rays are dangerous.” These arguments come in the form of recycled allopathic “red flag only” medical guidelines for spine care, opinion pieces and consensus statements. Herein, we review these common arguments and present compelling data refuting such claims. It quickly becomes evident that these statements are false. They are based on cherry-picked medical references and, most importantly, expansive evidence against this narrative continues to be ignored. Factually, there is considerable evidential support for routine use of radiological imaging in chiropractic and manual therapies for 3 main purposes: 1. To assess spinopelvic biomechanical parameters; 2. To screen for relative and absolute contraindications; 3. To reassess a patient’s progress from some forms of spine altering treatments. Finally, and most importantly, we summarize why the long-held notion of carcinogenicity from X-rays is not a valid argument.

Not only is low dose radiation not detrimental, but it also protects us from cancer, according to the authors:

Exposures to low-dose radiation incites multiple and multi-hierarchical biopositive mechanisms that prevent, repair or remove damage caused mostly by endogenous reactive oxygen species (ROS) and H2O2 from aerobic metabolism. Indeed, non-radiogenic (i.e. naturally occurring) molecular damage occurs daily at rates many orders of magnitude greater than the rate of damage caused by low-dose radiation such as diagnostic X-rays. It is estimated that the endogenous genetic damage caused on a daily basis from simply breathing air is about one million times the damage initially resulting from an X-ray. We concur that “it is factually preposterous to have radiophobic cancer concerns from medical X-rays after considering the daily burden of endogenous DNA damage.”

And, of course, radiological imaging makes sense in cases of non-specific back pain due to ‘malalignment’ of the spine:

Pressures to restrict the use of “repeat” (i.e. follow-up) X-rays for assessing patient response to treatment shows a complete disregard for the evidence discussed that definitively illustrates how modern spine rehabilitation techniques and practices successfully re-align the spine and pelvis for a wide variety of presenting subluxation/deformity patterns. The continued anti-X-ray sentiment from “consensus” and opinion within chiropractic needs to stop; it is antithetical to scientific reality and to the practice of contemporary chiropractic practice. We reiterate a quote from the late Michael A. Persinger: “what is happening in recent years is that facts are being defined by consensus. If a group of people think that something is correct, therefore it’s true, and that’s contradictory to science.”

Thus, the authors feel entitled to conclude:

Routine and repeat X-rays in the nonsurgical treatment of patients with spine disorders is an evidence-based clinical practice that is warranted by those that practice spine-altering methods. The evidence supporting such practices is based on definitive evidence supporting the rationale to assess a patient’s spinopelvic parameters for biomechanical diagnosis, to screen for relative and absolute contraindications for specific spine care methods, and to re-assess the spine and postural response to treatment.

The traditional and underlying presumption of the carcinogenicity from X-rays is not a valid notion because the LNT is not valid for low-dose exposures. The ALARA radiation protection principle is obsolete, the threshold for harm is high, low-dose exposures prevent cancers by stimulating and upregulating the body’s innate adaptive protection mechanisms, the TCD concept in invalid, and aged cohort studies assumed to show cancers resulting from previous X-rays are not generalizable to the wider population because they represent populations predisposed to cancers.

Red flags, or suspected serious underlying disease is a valid consideration warranting screening imaging by all spine care providers. We contend, however, that as long as the treating physician or rehabilitation therapist is practicing evidence-based methods, proven to improve spine and postural parameters in order to provide relief for the myriad of spinal disorders, spinal X-rays are unequivocally justified. Non-surgical spine care guidelines need to account for proven and evolving non-surgical methods that are radiographically guided, patient-centered, and competently practiced by those specialty trained in such methods. This is over and above so-called “red flag only” guidelines. The efforts to universally dissuade chiropractors from routine and repeat X-ray imaging is neither scientifically justified nor ethical.

There seems to be just one problem here: the broad consensus is against almost anything these authors claim.

Oh, I almost forgot: this paper was authored and sponsored by CBP NonProfit.

“The mission of Chiropractic BioPhysics® (CBP®) Non-Profit is to provide a research based response to these changing times that is clinically, technically, and philosophically sound. By joining together, we can participate in the redefinition and updating of the chiropractic profession through state of the art spine research efforts. This journey, all of us must take as a Chiropractic health care profession to become the best we can be for the sake of the betterment of patient care. CBP Non-Profit’s efforts focus on corrective Chiropractic care through structural rehabilitation of the spine and posture. Further, CBP Non-Profit, Inc. has in its purpose to fund Chiropractic student scholarships where appropriate as well as donate needed chiropractic equipment to chiropractic colleges; always trying to support chiropractic advancement and education.”

 This study aimed to evaluate the effect of Traditional Chinese Medicine (TCM) on patients with gastric cancer following surgery and adjuvant chemotherapy in Taiwan. The cohort sampling data set was obtained from the Registry of Catastrophic Illness Patient Database, a research database of patients with severe illnesses from the National Health Insurance Research Database, Taiwan. Patients who had received a new diagnosis of gastric cancer and had undergone surgery were enrolled. the researchers matched TCM users and nonusers at a ratio of 1 : 3 based on the propensity score, and TCM users were also grouped into short-term and long-term users.

The number of TCM users and nonusers was 1701 and 5103 after applying the propensity score at a ratio of 1 : 3. Short-term users and long-term TCM users were independently associated with a decreased risk of death with HRs of 0.59 (95% confidence interval (CI), 0.55-0.65) and 0.41 (95% CI, 0.36-0.47), respectively, compared with TCM nonusers. The researchers also obtained similar results when they adjusted for covariates in the main model, as well as each of the additional listed covariates. They also observed similar HR trends in short-term users and long-term TCM users among men and women aged <65 years and ≥65 years. The most commonly prescribed single herb and herbal formula in our cohort were Hwang-Chyi (Radix Hedysari; 11.8%) and Xiang-Sha-Liu-Jun-Zi-Tang (15.5%), respectively.

The authors concluded that TCM use was associated with higher survival in patients with gastric cancer after surgery and adjuvant chemotherapy. TCM could be used as a complementary and alternative therapy in patients with gastric cancer after surgery and adjuvant chemotherapy.

This is an interesting study which seems well-done – except for one fatal mistake: even in the title, the authors imply a causal relationship between TCM and survival. Their conclusion has two sentences; the first one speaks correctly of an association. The second, however, not only implies causality but goes much further in suggesting that TCM should be used to prolong the life of patients. Yet, there are, of course, dozens of factors that could interfere with the findings or be the true cause of the observed outcome.

Anyone with a minimum of critical thinking ability should know that CORRELATION IS NOT CAUSATION; sadly, the authors of this study seem to be the exception.

Scientists from Israel and Iceland recently suggested that an extract of spirulina algae has the potential to reduce the chances of COVID-19 patients developing a serious case of the disease. Here is the abstract of their paper:

An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respiratory distress syndrome (ARDS). Recognizing the therapeutic potential of Spirulina blue-green algae (Arthrospira platensis), in this in vitro stimulation study, LPS-activated macrophages and monocytes were treated with aqueous extracts of Spirulina, cultivated in either natural or controlled light conditions. We report that an extract of photosynthetically controlled Spirulina (LED Spirulina), at a concentration of 0.1 µg/mL, decreases macrophage and monocyte-induced TNF-α secretion levels by over 70% and 40%, respectively. We propose prompt in vivo studies in animal models and human subjects to determine the putative effectiveness of a natural, algae-based treatment for viral CS and ARDS, and explore the potential of a novel anti-TNF-α therapy.

The Jerusalem Post reported that the research was conducted in a MIGAL laboratory in northern Israel with algae grown and cultivated by the Israeli company VAXA, which is located in Iceland. VAXA received funding from the European Union to explore and develop natural treatments for coronavirus. Iceland’s MATIS Research Institute also participated in the study.

In a small percentage of patients, infection with the coronavirus causes the immune system to release an excessive number of TNF-a cytokines, resulting in what is known as a cytokine storm. The storm causes acute respiratory distress syndrome and damage to other organs, the leading cause of death in COVID-19 patients. “If you control or are able to mitigate the excessive release of TNF-a, you can eventually reduce mortality,” said Asaf Tzachor, a researcher from the IDC Herzliya School of Sustainability and the lead author of the study. During cultivation, growth conditions were adjusted to control the algae’s metabolomic profile and bioactive molecules. The result is what Tzachor refers to as “enhanced” algae.

Tzachor said that despite the special growth mechanism, the algae are a completely natural substance and should not produce any side effects. Spirulina is approved by the US Food and Drug Administration as a dietary substance. It is administrated orally in liquid drops. “This is natural, so it is unlikely that we would see an adverse or harmful response in patients as you sometimes see in patients that are treated with chemical or synthetic drugs,” he said. The algae have been shown to reduce inflammation. Tzachor said that if proven effective, spirulina could also be used against other coronaviruses and influenza. “If we succeed in the next steps,” said Dr. Dorit Avni, director of the laboratory at MIGAL, “there is a range of diseases that can be treated using this innovative solution – as a preventative treatment or a supportive treatment.”

___________________________

This is undoubtedly interesting, and one can only hope that their research is successful. However, it is a far cry from what some journalists are already making of the news. One headline read: “Scientists Discover ‘All-Natural’ COVID Treatment That Can Prevent ‘Cytokine Storm’ In Severe Patients.”

 

 

 

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