MD, PhD, FMedSci, FRSB, FRCP, FRCPEd.

A low intake of selenium has been associated with increased cardiovascular mortality in some epidemiological studies. This could be reduced by supplementation with selenium and coenzyme Q10. D-dimer, a fragment of fibrin mirroring fibrinolysis, is a biomarker of thromboembolism, increased inflammation, endothelial dysfunction and is associated with cardiovascular mortality in ischemic heart disease.

The objective of this trial was to examine the impact of selenium and coenzyme Q10 on the level of D-dimer, and its relationship to cardiovascular mortality. D-dimer was measured in 213 individuals at the start and after 48 months of a randomised double-blind placebo-controlled trial with selenium yeast (200 µg/day) and coenzyme Q10 (200 mg/day) (n = 106) or placebo (n = 107). The follow-up time was 4.9 years.

All included individuals were low in selenium (mean 67 μg/L, SD 16.8). The differences in D-dimer concentration were evaluated by the use of T-tests, repeated measures of variance, and ANCOVA analyses. At the end, a significantly lower D-dimer concentration was observed in the active treatment group in comparison with those on placebo (p = 0.006). Although D-dimer values at baseline were weakly associated with high-sensitive CRP, while being more strongly associated with soluble tumour necrosis factor receptor 1 and sP-selectin, controlling for these in the analysis there was an independent effect on D-dimer.

In participants with a D-dimer level above median at baseline, the supplementation resulted in significantly lower cardiovascular mortality compared to those on placebo (p = 0.014). All results were validated with a persisting significant difference between the two groups.

The authors concluded that supplementation with selenium and coenzyme Q10 in a group of elderly low in selenium and coenzyme Q10 prevented an increase in D-dimer and reduced the risk of cardiovascular mortality in comparison with the placebo group. The obtained results also illustrate important associations between inflammation, endothelial function and cardiovascular risk.

These results are interesting and potentially important. The authors agree that their study is not fully conclusive: “Even if the size of the study population is small, we regard the results as being interesting from a scientific point of view, and for hypothesis-generating. The included participants represented a relatively narrow age stratum, so it is not possible to extrapolate the results to other age groups without uncertainty. Finally, as the evaluated population consisted of Caucasians who were low in selenium and coenzyme Q10, it is not necessarily true that the obtained results could be extrapolated to another population.” It might furthermore be of interest to note that part of the analysis cost was supported by grants from Pharma Nord Aps, Denmark, the County Council of Östergötland, Linköping University.

What is needed next, I think, are independent replications. Also of interest would be to determine whether the effects are due to the selenium, or the Q10, or both. And finally, one must caution consumers to not overdose on selenium which could have a host of negative effects on health.

3 Responses to Supplementation with Selenium and Coenzyme Q 10 May Lower Cardiovascular Mortality

  • Well I was shocked to read this ‘SCAM’ idea such as supplementing with nutrition! But typical of mainstream medics, they insist on isolating specific compounds as if they were patented drugs. The body doesn’t work that way.

    Selenium like many other minerals and vitamins is involved in numerous interactions with other actors in the human body.
    Some poorly designed trials have attempted to discredit Vitamin D as an isolated potential treatment for Covid sufferers. My suggestion for optimising our Innate & Adaptive immune system is as follows:
    + Liposome Vitamin D3 + Vitamin K2-MK7 (dosage would be dependent on current level of serum 25(OH)D present in the subject.
    + Vitamin C Complex (whole foods), not synthetic ascorbic acid.
    + Vitamin A
    + Vitamin B Complex
    + Zinc
    + Selenium
    + Magnesium
    + Phosphorous
    Plus other nutrients in trace amounts.
    Matt Hancock lied in the house Of Commons when he claimed there was a published study that proved Vitamin D had no effect on preventing or treating covid-19. His advisers were quick to correct his untrue claim, saying the Health Minister ‘misspoke’ and such a trial didn’t exist…..Well that’s all right then!

    • the Tories have lied about so many things, so why not about a clinical trial?

    • When I view this website a banner appears at the top of the page which contains the following statement:

      Please remember: if you make a claim in a comment, support it with evidence.

      I’m assuming you see the same banner Mr Grant. Why do you choose to ignore it?

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