This double-blind RCT aimed to test the efficacy of self-administered acupressure for pain and physical function in adults with knee osteoarthritis (KOA). 150 patients with symptomatic KOA participated and were randomized to verum acupressure, sham acupressure, or usual care. Verum and sham, but not usual care, participants were taught to self-apply acupressure once daily, five days/week for